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Circulation Research. 1955;3:290-292

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(Circulation Research. 1955;3:290.)
© 1955 American Heart Association, Inc.

The Effects of Diphenylhydantoin Sodium, Glucose and {beta}-Diethylaminoethyl Diphenylpropylacetate Hydrochloride on Cyclopropane-Epinephrine Arrhythmias in the Dog

C. W. WHITE JR. A.M., M.D.1, ROBERT MEGIRIAN M.S.1, EDWARD D. SWISS A.M., PH.D.1

1 Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts

Diphenylhydantoin sodium, glucose, and {beta}-diethylaminoethyl diphenylpropylacetate hydrochloride were tested for their effects upon the cyclopropane-epinephrine arrhythmias. Diphenylhydantoin in a small dose enhanced the arrhythmias and in a larger dose controlled them when given by vein, but its action following oral administration was uncertain. Glucose increased both the duration and the severity of ventricular ectopic rhythms while {beta}-diethylaminoethyl diphenylpropylacetate increased the dose of epinephrine which initiated them.

Submitted on December 20, 1954




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E. N. MERCER and J. A. OSBORNE
The Current Status of Diphenylhydantoin in Heart Disease
Ann Intern Med, November 1, 1967; 67(5): 1084 - 1107.
[Abstract] [PDF]


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