© 1969 American Heart Association, Inc.
Mechanism of the Effects of Furosemide on Renin Secretion in Anesthetized Dogs
1 Department of Physiology, University of Michigan Ann Arbor, Michigan 48104
Furosemide was administered to anesthetized dogs in priming doses of 0.1, 0.5, or 2.5 mg/kg followed by the same amounts per hour as infusion. When sodium and water balances were maintained constant by the continuous replacement of urinary losses with isotonic saline, the renal venous renin activity (and renin release) was not altered by the 0.1 mg/kg dose but was significantly increased by the two larger doses. This increase was manifest within 5 to 10 minutes. The larger doses also increased mean arterial pressure but did not change plasma sodium or glomerular filtration rate. Renal plasma flow was increased by the 2.5 mg/kg dose but not by the 0.5 mg/kg. In another group of dogs in which salt depletion was allowed to occur, 0.1 mg/kg produced an increased renin release within 30 minutes; this increase was completely reversed by the replacement of sodium and water losses. In this group of dogs, the glomerular filtration rate decreased and then returned to control values after restoration of fluid balance. It is hypothesized that the two higher doses of furosemide stimulated renin release by directly inhibiting macula densa sodium transport, and that the reported effects of all natriuretics can be explained in terms of a single macula densa theory.
Key Words: angiotensin • macula densa • diuretics • sodium reabsorption • natriuretics • renal hemodynamics
Submitted on April 14, 1969
Accepted on June 17, 1969
This article has been cited by other articles:
 |
|
 |
|
  H. Castrop and J. Schnermann Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance Am J Physiol Renal Physiol, October 1, 2008; 295(4): F859 - F866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Beierwaltes Alternative renin regulatory pathways and the NKCC1 isoform Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1183 - F1184. [Full Text] [PDF]
|
|
|
|
|
|
H. Castrop, F. Schweda, D. Mizel, Y. Huang, J. Briggs, A. Kurtz, and J. Schnermann Permissive role of nitric oxide in macula densa control of renin secretion Am J Physiol Renal Physiol, May 1, 2004; 286(5): F848 - F857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schnermann Juxtaglomerular cell complex in the regulation of renal salt excretion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R263 - R279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. LOWDER and G. W. LIDDLE Effects of Guanethidine and Methyldopa on a Standardized Test for Renin Responsiveness Ann Intern Med, June 1, 1975; 82(6): 757 - 760. [Abstract] [PDF]
|
|
|
|
 |
|
 P. G. Schmid and F. M. Abboud Neurohumoral Control of Vascular Resistance Arch Intern Med, June 1, 1974; 133(6): 935 - 945. [Abstract] [PDF]
|
|
|
|
|
|
J. H. Stein and T. F. Ferris The Physiology of Renin Arch Intern Med, June 1, 1973; 131(6): 860 - 872. [Abstract] [PDF]
|
|
|
|
|
|
V. K. G. Pillay, V. C. Gandhi, B. K. Sharma, E. C. Smith, and G. Dunea Effect of Hydration and Furosemide Given Intravenously on Proteinuria Arch Intern Med, July 1, 1972; 130(1): 90 - 92. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Barajas Renin Secretion: An Anatomical Basis for Tubular Control Science, April 30, 1971; 172(3982): 485 - 487. [Abstract] [PDF]
|
|