© 1969 American Heart Association, Inc.
Certain Histological and Chemical Responses of the Vascular Interface to Acutely Induced Mechanical Stress in the Aorta of the Dog
1 Section on Clinical Biophysics, Cardiology Branch, National Heart Institute Bethesda, Maryland 20014
The purpose of this study is to quantify certain histologic and chemical responses of the intimal tissues in vivo to acutely induced mechanical stresses. Evans blue dye was given to tag serum albumin and an artificial fat emulsion was infused so that altered fluxes of either serum proteins or the artificial chylomicrons across the vascular interface into the intimal region could be detected. Special histologic and photodensimetric techniques were developed to estimate these fluxes as well as the architectural changes in the endothelial cell population. Architectural changes were quantified by doing endothelial cell counts to quantify the "normal" and "abnormal" endothelial cell population density as a function of stress exposure. The stress corresponding to the greatest rate of change of normal to abnormal cell forms is defined as the acute critical yield stress (
c) and was found to average < 420 dynes/cm2. Similarly the stress at which the greatest number of cells are being eroded is defined as the erosion stress (e). The flux of Evans blue dye into the intima increased with pressure or wall strain, with shearing stress, and with increased turbulence. The flux of artificial chylomicrons into the intimal region never occurred in the presence of a normal endothelial cell population and was found to be most heavy in areas of total cellular erosion.
Key Words: endothelial cell • yield stress • erosion stress • erosion • injury • damage • rheology • vascular interface • permeability • shearing stress • chemistry • Evans blue dye • fat deposition • vascular fluid mechanics • turbulence • pressure • thoracic aorta • atherosclerosis • intravenous fat infusion
Accepted on November 14, 1968
This article has been cited by other articles:
 |
|
 |
|
  C.G. Caro Discovery of the Role of Wall Shear in Atherosclerosis Arterioscler Thromb Vasc Biol, February 1, 2009; 29(2): 158 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C.H. John Biomechanics of Coronary Artery and Bypass Graft Disease: Potential New Approaches Ann. Thorac. Surg., January 1, 2009; 87(1): 331 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. O'Rourke Arterial aging: pathophysiological principles Vascular Medicine, November 1, 2007; 12(4): 329 - 341. [Abstract] [PDF]
|
|
|
|
 |
|
 D. L. Fry Arterial intimal-medial permeability and coevolving structural responses to defined shear-stress exposures Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2341 - H2355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Patel, S. Sailesh, S. Panja, and E. Kohner Retinal perfusion pressure and pulse pressure: clinical parameters predicting progression to sight-threatening diabetic retinopathy The British Journal of Diabetes & Vascular Disease, August 1, 2001; 1(1): 80 - 87. [Abstract] [PDF]
|
|
|
|
 |
|
 H M Snow, F Markos, D O'Regan, and K Pollock Characteristics of arterial wall shear stress which cause endothelium-dependent vasodilatation in the anaesthetized dog J. Physiol., March 15, 2001; 531(3): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Malek, S. L. Alper, and S. Izumo Hemodynamic Shear Stress and Its Role in Atherosclerosis JAMA, December 1, 1999; 282(21): 2035 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Pearson and H. V. Schaff Effects of cardioplegic solutions on vasoreactivity of the internal mammary artery Ann. Thorac. Surg., August 1, 1998; 66(2): 311 - 312. [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Santillan, M. Sato, and R. J. Bing Effect of Serotonin on Albumin and Low Density Lipoprotein Uptake in Perfused Rabbit Femoral Arteries Angiology, November 1, 1984; 35(11): 694 - 700. [Abstract] [PDF]
|
|
|
|
|
|
M. Zamir and N. Brown Pressure Rise at Arterial Bifurcations Angiology, October 1, 1984; 35(10): 645 - 658. [Abstract] [PDF]
|
|
|
|
 |
|
 J. B. Towne, K. Quinn, S. Salles-Cunha, V. M. Bernhard, and L. J. Clowry Effect of Increased Arterial Blood Flow on Localization and Progression of Atherosclerosis Arch Surg, November 1, 1982; 117(11): 1469 - 1474. [Abstract] [PDF]
|
|
|
|
|
|
A. Tanimura, K. Adachi, and T. Nakashima Permeability into Aortic Intima and Atherosclerotic Plaque Angiology, August 1, 1980; 31(8): 542 - 548. [PDF]
|
|
|
|
|
|
R. M. Green, M. Thomas, N. Luka, and J. A. DeWeese A Comparison of Rapid-Healing Prosthetic Arterial Grafts and Autogenous Veins Arch Surg, August 1, 1979; 114(8): 944 - 947. [Abstract] [PDF]
|
|
|
|
|
|
S. Bjorkerud Injury and Repair in Arterial Tissue: Experimental Models: Types and Relevance To Human Vascular Diseases a Survey Angiology, October 1, 1974; 25(10): 636 - 643. [PDF]
|
|