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(Circulation Research. 2008;102:1155.)
© 2008 American Heart Association, Inc.

Reviews

The Stem Cell Movement

Nicola Smart, Paul R. Riley

From the University College London-Institute of Child Health, United Kingdom.

Correspondence to Dr Paul R. Riley, Molecular Medicine Unit, UCL-Institute of Child Health, 30 Guilford St, London WC1N 1EH, United Kingdom. E-mail P.Riley{at}ich.ucl.ac.uk

This Review is part of a thematic series on Cellular Therapy, which includes the following articles:

The Stem Cell Movement

Genetic Enhancement of Stem Cell Engraftment, Survival, and Efficacy Disease and Aging As Modifiers of Efficacy Paracrine Signaling in Cell Transplantation Assessment and Optimization of Cell Engraftment After Transplantation Immune Biology of Stem Cells Cardiogenic Differentiation and Transdifferentiation of Stem Cells Stem Cell Homing to Sites of Injury Regulatory Considerations in Cell Transplantation
Eduardo Marbán Editor

Stem or progenitor cell–based strategies to combat ischemic heart disease and myocardial infarction, whether autologous transplantation or stimulation of resident populations, not only require detailed insight into transdifferentiation potential and functional coupling, but the efficacy of this approach is underpinned by the need to induce appropriate migration and homing to the site of injury. This review focuses on existing insights into the trafficking of stem cells in the context of cardiac regenerative therapy, with particular focus on the wide variety of potential sources of cells, critical factors that may regulate their migration, and how extrapolating from embryonic stem/progenitor cell behavior during cardiogenesis may reveal pathways implicit in the adult heart postinjury.

Key Words: cardiac stem cells • migration • homing • mobilization