This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gimble, J. M. Articles by Bunnell, B. A. Search for Related Content PubMed PubMed Citation Articles by Gimble, J. M. Articles by Bunnell, B. A. Related Collections Obesity Cell biology/structural biology Developmental biology Ischemic biology - basic studies Myogenesis Other Treatment

(Circulation Research. 2007;100:1249.)
© 2007 American Heart Association, Inc.

Reviews

Adipose-Derived Stem Cells for Regenerative Medicine

Jeffrey M. Gimble, Adam J. Katz, Bruce A. Bunnell

From the Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center (J.M.G.), Louisiana State University System, Baton Rouge; Department of Plastic and Maxillofacial Surgery (A.J.K.), University of Virginia, Charlottesville; and Tulane University Primate Research Center (B.A.B.), Covington, La.

Correspondence to Dr Jeffrey Gimble, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge 70808. E-mail gimblejm{at}pbrc.edu

This Review is part of a thematic series on the Pathobiology of Obesity, which includes the following articles:

Adipose-Derived Stem Cells for Regenerative Medicine

Obesity: Energy Metabolism at the Heart of the Problem

Lipid Disorders and the Metabolic Syndrome

Obesity and Leptin Resistance

Adiponectin as a Cardiovascular Protectant
Gary Lopaschuk Guest Editor

The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

Key Words: adipose tissue • adult stem cells • bone marrow stromal cell • differentiation • tissue engineering

This article has been cited by other articles:

				R. Madonna, Y.-J. Geng, and R. De Caterina Adipose Tissue-Derived Stem Cells: Characterization and Potential for Cardiovascular Repair Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1723 - 1729. [Abstract] [Full Text] [PDF]

				C. Bouffi, F. Djouad, M. Mathieu, D. Noel, and C. Jorgensen Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit? Rheumatology, October 1, 2009; 48(10): 1185 - 1189. [Abstract] [Full Text] [PDF]

				Y. Zhang, A. Daquinag, D. O. Traktuev, F. Amaya-Manzanares, P. J. Simmons, K. L. March, R. Pasqualini, W. Arap, and M. G. Kolonin White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models Cancer Res., June 15, 2009; 69(12): 5259 - 5266. [Abstract] [Full Text] [PDF]

				Y. Tabata Biomaterial technology for tissue engineering applications J R Soc Interface, June 6, 2009; 6(Suppl_3): S311 - S324. [Abstract] [Full Text] [PDF]

				K.-H. Mak, D. L. Bhatt, M. Shao, S. M. Haffner, C. W. Hamm, G. J. Hankey, S. C. Johnston, G. Montalescot, P. G. Steg, S. R. Steinhubl, et al. The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease Eur. Heart J., April 1, 2009; 30(7): 857 - 865. [Abstract] [Full Text] [PDF]

				S. Poglio, S. Galvani, S. Bour, M. Andre, B. Prunet-Marcassus, L. Penicaud, L. Casteilla, and B. Cousin Adipose Tissue Sensitivity to Radiation Exposure Am. J. Pathol., January 1, 2009; 174(1): 44 - 53. [Abstract] [Full Text] [PDF]

				P. E. Westerweel and M. C. Verhaar Directing Myogenic Mesenchymal Stem Cell Differentiation Circ. Res., September 12, 2008; 103(6): 560 - 561. [Full Text] [PDF]