doi: 10.1161/01.RES.0000266449.37396.1f
© 2007 American Heart Association, Inc.
Reviews |
Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
From the Division of Endocrinology, Diabetes, and Hypertension (W.H.), and Department of Medicine, Division of Cardiology (R.C.D.), The David Geffen School of Medicine, University of California, Los Angeles; Division of Endocrinology, Metabolism, and Diabetes (E.D.A. and D.A.M.) and Program in Human Molecular Biology and Genetics (E.D.A.), University of Utah, Salt Lake City; Laboratory of Biochemical Genetics and Metabolism (J.L.B.), The Rockefeller University, New York; Department of Pathology and Laboratory Medicine (N.M.), University of North Carolina, Chapel Hill; Department of Medicine (E.A.F.), The Marc and Ruti Bell Program in Vascular Biology, The Leon H. Charney Division of Cardiology, New York University School of Medicine; Department of Medicine (H.D., I.J.G.), Columbia University, New York; Center for Biotechnology and Genomic Medicine (R.M.), Medical College of Georgia, Augusta; and Division of Heart and Vascular Diseases (M.K.W., C.R.-D.), National Heart, Lung, and Blood Institute, Bethesda, Md.
Correspondence to Ira J. Goldberg, Department of Medicine, Columbia University, 630 West 168th St, PH10–305, New York, NY 10032. E-mail ijg3{at}columbia.edu
This Review is part of a thematic series on the Atherosclerosis in Diabetes: Dyslipidemia Versus Hyperglycemia, which includes the following articles: Do Glucose and Lipids Exert Independent Effects on Atherosclerotic Lesion Initiation or Progression to Advanced Plaques?
Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis Lipids, Glucose, and Oxidative Reactions in Diabetes and Atherosclerosis
Karin E. Bornfeldt Guest Editor
For more than 50 years, investigators have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of diabetes seen in humans. In particular, accelerated atherosclerosis and dilated cardiomyopathy, the major causes of mortality in patients with diabetes, have been conspicuously absent in many mouse models of the disease. Under the auspices of the NIH, the Animal Models of Diabetic Complications Consortium has worked to address this issue. This effort has focused on the development of mouse models because of the high level of genomic information available and the many well-developed genetic manipulations that may be performed in mice. Importantly, the consortium has also worked to standardize many methods to assess metabolic and cardiovascular end points for measurement of the diabetic state and its macrovascular complications. Finally, for maximum benefits from these animal models in the study of atherosclerosis and of other diabetic complications, the consortium has created a system for sharing both the animal models and the accumulated phenotypic data with the greater scientific community.
Key Words: atherosclerosis • diabetes mellitus • diabetic cardiomyopathy • transgenic mice
This article has been cited by other articles:
 |
|
 |
|
  R. Basu, G. Y. Oudit, X. Wang, L. Zhang, J. R. Ussher, G. D. Lopaschuk, and Z. Kassiri Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2096 - H2108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, H. Chen, R. H. Muzumdar, F. H. Einstein, X. Yan, L. Q. Yue, N. Barzilai, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1023 - E1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Cook, A. Varela-Carver, M. Mongillo, C. Kleinert, M. T. Khan, L. Leccisotti, N. Strickland, T. Matsui, S. Das, A. Rosenzweig, et al. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction Eur. Heart J., October 1, 2009; (2009) ehp396v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-Y. Song, Y.-J. Wu, Y.-J. Yang, J.-J. Li, H.-L. Zhang, H.-J. Pei, Z.-Y. Zhao, Z.-H. Zeng, and R.-T. Hui The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model Eur J Heart Fail, October 1, 2009; 11(10): 911 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nilsson-Ohman, G. N. Fredrikson, L. M. Nilsson-Berglund, C. Gustavsson, E. Bengtsson, M.-L. Smith, C.-D. Agardh, E. Agardh, S. Jovinge, M. F. Gomez, et al. Tumor Necrosis Factor-{alpha} Does Not Mediate Diabetes-Induced Vascular Inflammation in Mice Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1465 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pretorius, X.-J. Du, E. A. Woodcock, H. Kiriazis, R. C.Y. Lin, S. Marasco, R. L. Medcalf, Z. Ming, G. A. Head, J. W. Tan, et al. Reduced Phosphoinositide 3-Kinase (p110{alpha}) Activation Increases the Susceptibility to Atrial Fibrillation Am. J. Pathol., September 1, 2009; 175(3): 998 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Messaoudi, P. Milliez, J.-L. Samuel, and C. Delcayre Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density FASEB J, July 1, 2009; 23(7): 2176 - 2185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Brasacchio, J. Okabe, C. Tikellis, A. Balcerczyk, P. George, E. K. Baker, A. C. Calkin, M. Brownlee, M. E. Cooper, and A. El-Osta Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail Diabetes, May 1, 2009; 58(5): 1229 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Collins, C. J. Lyon, X. Xia, J. Z. Liu, R. K. Tangirala, F. Yin, R. Boyadjian, A. Bikineyeva, D. Pratico, D. G. Harrison, et al. Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes Circ. Res., March 27, 2009; 104(6): e42 - e54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Connelly, D. J. Kelly, Y. Zhang, D. L. Prior, A. Advani, A. J. Cox, K. Thai, H. Krum, and R. E. Gilbert Inhibition of Protein Kinase C-{beta} by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy Circ Heart Fail, March 1, 2009; 2(2): 129 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bugger, S. Boudina, X. X. Hu, J. Tuinei, V. G. Zaha, H. A. Theobald, U. J. Yun, A. P. McQueen, B. Wayment, S. E. Litwin, et al. Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3 Diabetes, November 1, 2008; 57(11): 2924 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Maile, B. E. Capps, E. C. Miller, A. W. Aday, and D. R. Clemmons Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo Diabetes, October 1, 2008; 57(10): 2637 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Abel, S. E. Litwin, and G. Sweeney Cardiac Remodeling in Obesity Physiol Rev, April 1, 2008; 88(2): 389 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1{alpha} PNAS, February 19, 2008; 105(7): 2598 - 2603.
|
|
|
|
|
|
F. Johansson, F. Kramer, S. Barnhart, J. E. Kanter, T. Vaisar, R. D. Merrill, L. Geng, K. Oka, L. Chan, A. Chait, et al. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice PNAS, February 12, 2008; 105(6): 2082 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, R. Muniyappa, X. Yan, H. Chen, L. Q. Yue, E.-G. Hong, J. K. Kim, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E261 - E270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Connelly, D. Kelly, and R. Gilbert Clinically Relevant Models of Diabetic Cardiac Complications Circ. Res., September 14, 2007; 101(6): e78 - e78. [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Abel Glucose for the Aging Heart? Circulation, August 21, 2007; 116(8): 884 - 887. [Full Text] [PDF]
|
|