Published online before print February 16, 2006, doi: 10.1161/01.RES.0000210578.62102.a6
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on November 15, 2004
Revised on December 15, 2005
Accepted on February 3, 2006
Estrogen Receptor 
Gene Variation Is Associated With Risk of Myocardial Infarction in More Than Seven Thousand Men From Five Cohorts
Amanda M. Shearman *;
From the Center for Cancer Research (A.M.S., D.E.H.), Massachusetts Institute of Technology, Cambridge; Center for Cardiovascular Genetics (J.A.C., P.J.K., S.E.H.), Department of Medicine, Royal Free and University College London Medical School, Rayne Institute, United Kingdom; Portex Anaesthesia (P.J.K.), Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, United Kingdom; MRC Cardiovascular Research Group (G.J.M.), Wolfson Institute of Preventive Medicine, London, United Kingdom; Genomics Collaborative (K.G.A., B.J., K.I., K.L.L.), Cambridge, Mass; Departments of Internal Medicine and Epidemiology and Biostatistics (S.C.E.S., A.G.U., H.A.P.P.), Erasmus Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Boston University School of Public Health (S.D., L.A.C.), Mass; Tufts-New England Medical Center (M.E.M.), Boston, Mass; and the Framingham Heart Study of the National Heart, Lung, and Blood Institute (D.L.), Mass.
* To whom correspondence should be addressed. E-mail: shearman{at}mit.edu.
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor 
(ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction (odds ratio=1.63).
Key words: genetics • myocardial infarction • estrogen receptor • risk factors
This article has been cited by other articles:
 |
|
 |
|
  V. M. Miller and S. P. Duckles Vascular Actions of Estrogens: Functional Implications Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Bos, S. C.E. Schuit, P. J. Koudstaal, A. Hofman, A. G. Uitterlinden, and M. M.B. Breteler Variation in the Estrogen Receptor {alpha} Gene and Risk of Stroke: The Rotterdam Study Stroke, April 1, 2008; 39(4): 1324 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Douglas, M. Natalia Cruz, L. Poston, J.-A. Gustafsson, and K. Kublickiene Functional characterization and sex differences in small mesenteric arteries of the estrogen receptor- knockout mouse Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R112 - R120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Rexrode, P. M. Ridker, H. H. Hegener, J. E. Buring, J. E. Manson, and R. Y.L. Zee Polymorphisms and Haplotypes of the Estrogen Receptor-{beta} Gene (ESR2) and Cardiovascular Disease in Men and Women Clin. Chem., October 1, 2007; 53(10): 1749 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kato, B. Lindholm, J. Axelsson, R. A. Qureshi, P. Barany, O. Heimburger, J.-A. Gustafsson, P. Stenvinkel, and L. Nordfors Association between oestrogen receptor {alpha} gene polymorphism and mortality in female end-stage renal disease patients Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2571 - 2577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sun, C. Yan, A. Jacobson, H. Jiang, M. A. Carroll, and A. Huang Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ER{alpha} knockout mice: role of aromatase Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1239 - R1246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury Cardiovasc Res, August 1, 2007; 75(3): 478 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Alevizaki, K Saltiki, A Cimponeriu, I Kanakakis, N Xita, C C Alevizaki, I Georgiou, and H-L Sarika Severity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor {alpha} polymorphic variants Eur. J. Endocrinol., April 1, 2007; 156(4): 489 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Deschepper and B. Llamas Hypertensive Cardiac Remodeling in Males and Females: From the Bench to the Bedside Hypertension, March 1, 2007; 49(3): 401 - 407. [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Kjaergaard, C. Ellervik, A. Tybjaerg-Hansen, C. K. Axelsson, M.-L. M. Gronholdt, P. Grande, G. B. Jensen, and B. G. Nordestgaard Estrogen Receptor {alpha} Polymorphism and Risk of Cardiovascular Disease, Cancer, and Hip Fracture: Cross-Sectional, Cohort, and Case-Control Studies and a Meta-Analysis Circulation, February 20, 2007; 115(7): 861 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Pepine, W. W. Nichols, and D. F. Pauly Estrogen and Different Aspects of Vascular Disease in Women and Men Circ. Res., September 1, 2006; 99(5): 459 - 461. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Arnlov, M. J. Pencina, S. Amin, B.-H. Nam, E. J. Benjamin, J. M. Murabito, T. J. Wang, P. E. Knapp, R. B. D'Agostino Sr., S. Bhasin, et al. Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med, August 1, 2006; 145(3): 176 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Shearman Oestrogen receptor genetics: a needle that cuts through many haystacks? Eur. Heart J., July 1, 2006; 27(13): 1519 - 1520. [Full Text] [PDF]
|
|