Circulation Research. 2005
Published online before print March 17, 2005, doi: 10.1161/01.RES.0000163015.67711.AB
Published online before print March 17, 2005, doi: 10.1161/01.RES.0000163015.67711.AB
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Submitted on February 2, 2005
Revised on March 4, 2005
Accepted on March 7, 2005
Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans
Radjesh J. Bisoendial ;
From the Departments of Vascular Medicine (R.J.B., J.J.P.K., J.H.M.L., B.v.d.B., J.C.M.M., M.L., E.S.G.S.), Hematology (J.J.Z.), and Experimental Medicine (P.H.R.), Academic Medical Center, Amsterdam, the Netherlands; and Pfizer Global Research and Development (D.H.), Ann Arbor, Mich.
* To whom correspondence should be addressed. E-mail: e.s.stroes{at}amc.uva.nl.
C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on coagulation and inflammatory pathways to determine its role in atherothrombotic disease. Seven male volunteers received an infusion on two occasions, containing 1.25 mg/kg recombinant human CRP (rhCRP) or diluent, respectively. CRP-concentrations rose after rhCRP-infusion from 1.9 (0.3 to 8.5) to 23.9 (20.5 to 28.1) mg/L, and subsequently both inflammation and coagulation were activated. This sequence of events suggests that CRP is not only a well known marker of cardiovascular disease, but is also probably a mediator of atherothrombotic disease.
Key words: inflammation • endothelium • atherosclerosis • thrombosis
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