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Circulation Research. 2004
Published online before print August 19, 2004, doi: 10.1161/01.RES.0000142735.67542.5a
A more recent version of this article appeared on September 17, 2004
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Right arrow Cell signalling/signal transduction
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Submitted on June 1, 2004
Revised on August 5, 2004
Accepted on August 10, 2004

Phosphorylation Regulates Id3 Function in Vascular Smooth Muscle Cells

Scott T. Forrest ; Angela M. Taylor ; Ian J. Sarembock ; Demetra Perlegas ; and Coleen A. McNamara *

From the Cardiovascular Division, Department of Internal Medicine, and the Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, Va.

* To whom correspondence should be addressed. E-mail: cam8c{at}virginia.edu.

Understanding the mechanisms that regulate cell cycle progression in vascular smooth muscle cells (VSMCs) is key to understanding and modulating vascular lesion formation. Results of the present study provide the first evidence that phosphorylation of the helix-loop-helix factor Id3 in VSMCs occurs in vitro and in vivo and provides a regulatory switch controlling Id3-induced regulation of p21Cip1 and VSMC growth.
Key words: muscle • vascular • smooth • cell cycle • helix-loop-helix motifs • phosphorylation




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