Circulation Research. 2003
Published online before print March 27, 2003, doi: 10.1161/01.RES.0000069215.36389.8D
Published online before print March 27, 2003, doi: 10.1161/01.RES.0000069215.36389.8D
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 9, 2002
Revised on March 12, 2003
Accepted on March 18, 2003
Protein Kinase C
Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria
Christopher P. Baines *;
From the Departments of Physiology and Biophysics and Medicine/Division of Cardiology (C.P.B., C.-X.S., Y.-T.Z., O.-L.W., Y.G., R.B.), University of Louisville, Louisville, Ky; Departments of Physiology and Medicine/Division of Cardiology (G.-W.W., J.Z., E.M.C., P.P.), University of California at Los Angeles, Los Angeles, Calif.
* To whom correspondence should be addressed. E-mail: CPBaines{at}gmx.net.
Although functional coupling between protein kinase C
(PKC) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable this link and the identities of the mitochondrial proteins modulated by PKC remain unknown. Based on recent evidence that the mitochondrial permeability transition pore may be involved in ischemia/reperfusion injury, we hypothesized that protein-protein interactions between PKC and mitochondrial pore components may serve as a signaling mechanism to modulate pore function and thus engender cardioprotection. Coimmunoprecipitation and GST-based affinity pull-down from mouse cardiac mitochondria revealed interaction of PKC with components of the pore, namely voltage-dependent anion channel (VDAC), adenine nucleotide translocase (ANT), and hexokinase II (HKII). VDAC1, ANT1, and HKII were present in the PKC complex at 
2%, 0.2%, and 1% of their total expression, respectively. Moreover, in vitro studies demonstrated that PKC can directly bind and phosphorylate VDACs. Incubation of isolated cardiac mitochondria with recombinant PKC resulted in a significant inhibition of Ca2+-induced mitochondrial swelling, an index of pore opening. Furthermore, cardiac-specific expression of active PKC in mice, which is cardioprotective, greatly increased interaction of PKC with the pore components and inhibited Ca2+-induced pore opening. In contrast, cardiac expression of kinase-inactive PKC did not affect pore opening. Finally, administration of the pore opener atractyloside significantly attenuated the infarct-sparing effect of PKC transgenesis. Collectively, these data demonstrate that PKC forms physical interactions with components of the cardiac mitochondrial pore. This in turn inhibits the pathological function of the pore and contributes to PKC-induced cardioprotection.
Key words: mitochondria • signal transduction • permeability transition pore • cardioprotection
This article has been cited by other articles:
 |
|
 |
|
  E. N. Churchill, J. C. Ferreira, P. C. Brum, L. I. Szweda, and D. Mochly-Rosen Ischaemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion Cardiovasc Res, November 14, 2009; (2009) cvp334v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chen-Scarabelli, G. Faggian, Z. Yuan, M. Tessari, A. Rungatscher, J. Di Rezze, G. M. Scarabelli, K. Abounit, R. McCauley, L. Saravolatz, et al. Warm-blood cardioplegic arrest induces selective mitochondrial translocation of protein kinase C{epsilon} followed by interaction with 6.1 inwardly rectifying potassium channel subunit in viable myocytes overexpressing urocortin J. Thorac. Cardiovasc. Surg., November 1, 2009; 138(5): 1213 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Javadov, M. Karmazyn, and N. Escobales Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases J. Pharmacol. Exp. Ther., September 1, 2009; 330(3): 670 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Zorov, M. Juhaszova, Y. Yaniv, H. B. Nuss, S. Wang, and S. J. Sollott Regulation and pharmacology of the mitochondrial permeability transition pore Cardiovasc Res, July 15, 2009; 83(2): 213 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gurel, K. M. Smeele, O. Eerbeek, A. Koeman, C. Demirci, M. W. Hollmann, and C. J. Zuurbier Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion J Appl Physiol, June 1, 2009; 106(6): 1909 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rane, M. He, D. Sayed, H. Vashistha, A. Malhotra, J. Sadoshima, D. E. Vatner, S. F. Vatner, and M. Abdellatif Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1{alpha} and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes Circ. Res., April 10, 2009; 104(7): 879 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Garciarena, C. I. Caldiz, M. V. Correa, G. R. Schinella, S. M. Mosca, G. E. Chiappe de Cingolani, H. E. Cingolani, and I. L. Ennis Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action J Appl Physiol, December 1, 2008; 105(6): 1706 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nguyen, M. Ogbi, and J. A. Johnson Delta Protein Kinase C Interacts with the d Subunit of the F1F0 ATPase in Neonatal Cardiac Myocytes Exposed to Hypoxia or Phorbol Ester: IMPLICATIONS FOR F1F0 ATPase REGULATION J. Biol. Chem., October 31, 2008; 283(44): 29831 - 29840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhai and J. Sadoshima Overcoming an Energy Crisis?: An Adaptive Role of Glycogen Synthase Kinase-3 Inhibition in Ischemia/Reperfusion Circ. Res., October 24, 2008; 103(9): 910 - 913. [Full Text] [PDF]
|
|
|
|
|
|
J. Feng, M. Zhu, M. C. Schaub, P. Gehrig, B. Roschitzki, E. Lucchinetti, and M. Zaugg Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function Cardiovasc Res, October 1, 2008; 80(1): 20 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Quinlan, A. D. T. Costa, C. L. Costa, S. V. Pierre, P. Dos Santos, and K. D. Garlid Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channels Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H953 - H961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, N. Oka, M. Tropak, J. Callahan, J. Lee, G. Wilson, A. Redington, and C. A. Caldarone Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest. J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yuan, Y. Fu, X. Wang, H. Shi, Y. Huang, X. Song, L. Li, N. Song, and Y. Luo Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis FASEB J, August 1, 2008; 22(8): 2809 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shahid, M. Tauseef, K. K. Sharma, and M. Fahim Brief femoral artery ischaemia provides protection against myocardial ischaemia-reperfusion injury in rats: the possible mechanisms Exp Physiol, August 1, 2008; 93(8): 954 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yu, T. Nguyen, M. Ogbi, R. W. Caldwell, and J. A. Johnson Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-{varepsilon} inhibition Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2637 - H2645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Clarke, I. Khaliulin, M. Das, J. E. Parker, K. J. Heesom, and A. P. Halestrap Inhibition of Mitochondrial Permeability Transition Pore Opening by Ischemic Preconditioning Is Probably Mediated by Reduction of Oxidative Stress Rather Than Mitochondrial Protein Phosphorylation Circ. Res., May 9, 2008; 102(9): 1082 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Dave, R. A. DeFazio, A. P. Raval, A. Torraco, I. Saul, A. Barrientos, and M. A. Perez-Pinzon Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase C{varepsilon} J. Neurosci., April 16, 2008; 28(16): 4172 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Oka, L. Wang, W. Mi, and C. A. Caldarone Inhibition of mitochondrial remodeling by cyclosporine A preserves myocardial performance in a neonatal rabbit model of cardioplegic arrest J. Thorac. Cardiovasc. Surg., March 1, 2008; 135(3): 585 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Sun, S. Shukair, T. J. Naik, F. Moazed, and H. Ardehali Glucose Phosphorylation and Mitochondrial Binding Are Required for the Protective Effects of Hexokinases I and II Mol. Cell. Biol., February 1, 2008; 28(3): 1007 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sarioglu, S. Brandner, M. Haberger, C. Jacobsen, J. Lichtmannegger, M. Wormke, and U. Andrae Analysis of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Proteome Changes in 5L Rat Hepatoma Cells Reveals Novel Targets of Dioxin Action Including the Mitochondrial Apoptosis Regulator VDAC2 Mol. Cell. Proteomics, February 1, 2008; 7(2): 394 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Cai, H. Zhong, M. Bosch-Marce, K. Fox-Talbot, L. Wang, C. Wei, M. A. Trush, and G. L. Semenza Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1{alpha} Cardiovasc Res, February 1, 2008; 77(3): 463 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D.T. Costa, S. V. Pierre, M. V. Cohen, J. M. Downey, and K. D. Garlid cGMP signalling in pre- and post-conditioning: the role of mitochondria Cardiovasc Res, January 15, 2008; 77(2): 344 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Oka, L. Wang, W. Mi, W. Zhu, O. Honjo, and C. A. Caldarone Cyclosporine A prevents apoptosis-related mitochondrial dysfunction after neonatal cardioplegic arrest J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 123 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Liem, H. M. Honda, J. Zhang, D. Woo, and P. Ping Past and present course of cardioprotection against ischemia- reperfusion injury J Appl Physiol, December 1, 2007; 103(6): 2129 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Haden, H. B. Suliman, M. S. Carraway, K. E. Welty-Wolf, A. S. Ali, H. Shitara, H. Yonekawa, and C. A. Piantadosi Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 768 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Jiang, Y. Nakae, M. Ljubkovic, W.-M. Kwok, D. F. Stowe, and Z. J. Bosnjak Isoflurane Activates Human Cardiac Mitochondrial Adenosine Triphosphate-Sensitive K+ Channels Reconstituted in Lipid Bilayers Anesth. Analg., October 1, 2007; 105(4): 926 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Guo, T. Nguyen, M. Ogbi, H. Tawfik, G. Ma, Q. Yu, R. W. Caldwell, and J. A. Johnson Protein kinase C-{varepsilon} coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2219 - H2230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Korzick, J. C. Kostyak, J. C. Hunter, and K. W. Saupe Local delivery of PKC{varepsilon}-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2056 - H2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Townsend, S. M. Davidson, S. J. Clarke, I. Khaliulin, C. J. Carroll, T. M. Scarabelli, R. A. Knight, A. Stephanou, D. S. Latchman, and A. P. Halestrap Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H928 - H938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Baines The mitochondrial permeability transition pore as a target of cardioprotective signaling Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H903 - H904. [Full Text] [PDF]
|
|
|
|
|
|
S. L. House, S. J. Melhorn, G. Newman, T. Doetschman, and J. E. J. Schultz The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H354 - H365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Starnes, B. D. Barnes, and M. E. Olsen Exercise training decreases rat heart mitochondria free radical generation but does not prevent Ca2+-induced dysfunction J Appl Physiol, May 1, 2007; 102(5): 1793 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Karagulova, Y. Yue, A. Moreyra, M. Boutjdir, and I. Korichneva Protective Role of Intracellular Zinc in Myocardial Ischemia/Reperfusion Is Associated with Preservation of Protein Kinase C Isoforms J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 517 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lu, S. Ren, P. Korge, J. Choi, Y. Dong, J. Weiss, C. Koehler, J.-n. Chen, and Y. Wang A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development Genes & Dev., April 1, 2007; 21(7): 784 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Hunter, J. C. Kostyak, J. L. Novotny, A. M. Simpson, and D. H. Korzick Estrogen deficiency decreases ischemic tolerance in the aged rat heart: roles of PKC{delta}, PKC{epsilon}, Akt, and GSK3beta Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R800 - R809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kroemer, L. Galluzzi, and C. Brenner Mitochondrial Membrane Permeabilization in Cell Death Physiol Rev, January 1, 2007; 87(1): 99 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wall, J. Wei, M. Ly, P. Belmont, J. J. Martindale, D. Tran, J. Sun, W. J. Chen, W. Yu, P. Oeller, et al. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6 Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2462 - H2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Kukreja Mechanism of reactive oxygen species generation after opening of mitochondrial KATP channels Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2041 - H2043. [Full Text] [PDF]
|
|
|
|
|
|
H. Ardehali Signaling Mechanisms in Ischemic Preconditioning: Interaction of PKC{epsilon} and MitoKATP in the Inner Membrane of Mitochondria Circ. Res., October 13, 2006; 99(8): 798 - 800. [Full Text] [PDF]
|
|
|
|
|
|
M. Jaburek, A. D.T. Costa, J. R. Burton, C. L. Costa, and K. D. Garlid Mitochondrial PKC{epsilon} and Mitochondrial ATP-Sensitive K+ Channel Copurify and Coreconstitute to Form a Functioning Signaling Module in Proteoliposomes Circ. Res., October 13, 2006; 99(8): 878 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mayr, J. Zhang, A. S. Greene, D. Gutterman, J. Perloff, and P. Ping Proteomics-based Development of Biomarkers in Cardiovascular Disease: Mechanistic, Clinical, and Therapeutic Insights Mol. Cell. Proteomics, October 1, 2006; 5(10): 1853 - 1864. [Full Text] [PDF]
|
|
|
|
|
|
D. K. Arrell, S. T. Elliott, L. A. Kane, Y. Guo, Y. H. Ko, P. L. Pedersen, J. Robinson, M. Murata, A. M. Murphy, E. Marban, et al. Proteomic Analysis of Pharmacological Preconditioning: Novel Protein Targets Converge to Mitochondrial Metabolism Pathways Circ. Res., September 29, 2006; 99(7): 706 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. T. Costa, R. Jakob, C. L. Costa, K. Andrukhiv, I. C. West, and K. D. Garlid The Mechanism by Which the Mitochondrial ATP-sensitive K+ Channel Opening and H2O2 Inhibit the Mitochondrial Permeability Transition J. Biol. Chem., July 28, 2006; 281(30): 20801 - 20808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-S. Park, H. Zhao, Y. Jang, R. A. Mueller, and Z. Xu N6-(3-Iodobenzyl)-adenosine-5'-N-methylcarboxamide Confers Cardioprotection at Reperfusion by Inhibiting Mitochondrial Permeability Transition Pore Opening via Glycogen Synthase Kinase 3beta J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Jiang, M. Ljubkovic, Y. Nakae, Y. Shi, W.-M. Kwok, D. F. Stowe, and Z. J. Bosnjak Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1770 - H1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Di Lisa and P. Bernardi Mitochondria and ischemia-reperfusion injury of the heart: Fixing a hole Cardiovasc Res, May 1, 2006; 70(2): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inagaki, E. Churchill, and D. Mochly-Rosen Epsilon protein kinase C as a potential therapeutic target for the ischemic heart Cardiovasc Res, May 1, 2006; 70(2): 222 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Hausenloy and D. M. Yellon Survival kinases in ischemic preconditioning and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 240 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Zatta, H. Kin, G. Lee, N. Wang, R. Jiang, R. Lust, J. G. Reeves, J. Mykytenko, R. A. Guyton, Z.-Q. Zhao, et al. Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling Cardiovasc Res, May 1, 2006; 70(2): 315 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Dhalla, M. R. Dent, P. S. Tappia, R. Sethi, J. Barta, and R. K. Goyal Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2006; 11(1): 31 - 45. [Abstract] [PDF]
|
|
|
|
|
|
J.-C. Bopassa, R. Ferrera, O. Gateau-Roesch, E. Couture-Lepetit, and M. Ovize PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning Cardiovasc Res, January 1, 2006; 69(1): 178 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamura, C. Steenbergen, and E. Murphy Protein kinase C and preconditioning: role of the sarcoplasmic reticulum Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2484 - H2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Robia, M. Kang, and J. W. Walker Novel determinant of PKC-{epsilon} anchoring at cardiac Z-lines Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1941 - H1950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Malhotra, R. Begley, B. P. S. Kang, I. Rana, J. Liu, G. Yang, D. Mochly-Rosen, and L. G. Meggs PKC-{varepsilon}-dependent survival signals in diabetic hearts Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1343 - H1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okada, H. Otani, Y. Wu, T. Uchiyama, S. Kyoi, R. Hattori, T. Sumida, H. Fujiwara, and H. Imamura Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and phosphatidylinositol 3-kinase Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H761 - H767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Di Lisa and P. Bernardi Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition Cardiovasc Res, May 1, 2005; 66(2): 222 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wang, D. A. Liem, T. M. Vondriska, H. M. Honda, P. Korge, D. M. Pantaleon, X. Qiao, Y. Wang, J. N. Weiss, and P. Ping Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1290 - H1295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hassouna, B. M. Matata, and M. Galinanes PKC-{epsilon} is upstream and PKC-{alpha} is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1418 - C1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Brennan, R. Wait, S. Begum, J. R. Bell, M. J. Dunn, and P. Eaton Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis J. Biol. Chem., October 1, 2004; 279(40): 41352 - 41360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P Halestrap, S. J Clarke, and S. A Javadov Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection Cardiovasc Res, February 15, 2004; 61(3): 372 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Eefting, B. Rensing, J. Wigman, W. J. Pannekoek, W. M. Liu, M. J. Cramer, D. J Lips, and P. A Doevendans Role of apoptosis in reperfusion injury Cardiovasc Res, February 15, 2004; 61(3): 414 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Murphy Primary and Secondary Signaling Pathways in Early Preconditioning That Converge on the Mitochondria to Produce Cardioprotection Circ. Res., January 9, 2004; 94(1): 7 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Argaud, O. Gateau-Roesch, L. Chalabreysse, L. Gomez, J. Loufouat, F. Thivolet-Bejui, D. Robert, and M. Ovize Preconditioning delays Ca2+-induced mitochondrial permeability transition Cardiovasc Res, January 1, 2004; 61(1): 115 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ping Identification of Novel Signaling Complexes by Functional Proteomics Circ. Res., October 3, 2003; 93(7): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Weiss, P. Korge, H. M. Honda, and P. Ping Role of the Mitochondrial Permeability Transition in Myocardial Disease Circ. Res., August 22, 2003; 93(4): 292 - 301. [Abstract] [Full Text] [PDF]
|
|