Circulation Research. 2003
Published online before print March 13, 2003, doi: 10.1161/01.RES.0000065917.53950.75
Published online before print March 13, 2003, doi: 10.1161/01.RES.0000065917.53950.75
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Submitted on January 13, 2003
Revised on February 25, 2003
Accepted on February 27, 2003
The Endothelial Glycocalyx Protects Against Myocardial Edema
Bernard M. van den Berg ;
From the Department of Medical Physics, Academic Medical Center, University of Amsterdam, The Netherlands.
* To whom correspondence should be addressed. E-mail: h.vink{at}amc.uva.nl.
Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with electron microscopy, revealing that the rat myocardial capillary endothelial surface is coated with a 0.2- to 0.5-µm-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema.
Key words: myocardium • capillaries • glycocalyx • hyaluronan • edema
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