Correction
for
Matsui et al., Circ Res 103 (11) 1309-1318.
Circulation Research. 2009;104:e27-e29
doi: 10.1161/CIRCRESAHA.109.100002
(Circulation Research. 2009;104:e27.)
© 2009 American Heart Association, Inc.
Correction
In the article by Matsui et al, "Lats2 Is a Negative Regulator
of Myocyte Size in the Heart," which appeared in the November
21, 2008, issue of the journal (
Circulation. 2008;103:1309–1318),
Figures 4, 5, and 6
were unclear. Here are improved figures.
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Figure 4. Cardiac phenotype of Tg-Lats2 mice. A, Heart homogenates were prepared from normal mice subjected to either sham operation (sham) or TAC for 2 weeks, Tg-Lats2 (line 20), or NTg littermates and then immunoblotted with anti-Lats2 and anti– -actin antibodies. B, Postmortem measurements of LVW/TL (left) and RVW/TL (right) in Tg-Lats2 (line 8) and NTg. Values are means±SD. C, Echocardiographically measured LV end diastolic dimension (LVEDD) and LV ejection fraction (LVEF) in Tg-Lats2 (line 8) and NTg mice. Values are means±SEM. D, Representative wheat germ agglutinin (WGA) staining of the LV and RV myocardium obtained from Tg-Lats2 (line 8) and NTg mice (upper) and the relative myocyte cross sectional area (lower). Values are means±SEM obtained from 5 experiments. *P<0.05.
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Figure 5. Cardiac phenotype of Tg-DN-Lats2 mice. A, Immunoblot analyses of heart homogenates from Tg-DN-Lats2 (line 31) and NTg mice with anti-Lats2, anti-ANP, and anti–-actin antibodies. B, Postmortem measurements of LVW/TL (mg/mm, left) and RVW/TL (mg/mm, right) in Tg-DN-Lats2 (line 31) and NTg. Values are means±SD. N=12 to 16. C, Representative WGA staining of the LV myocardium obtained from Tg-DN-Lats2 and NTg mice (upper) and the relative myocyte cross-sectional area (lower). Values are means±SEM obtained from 5 experiments.
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Figure 6. Effects of TAC on cardiac hypertrophy in Tg-DN-Lats2 mice. Tg-DN-Lats2 (line 31) and NTg were subjected to either TAC (2 weeks) or sham operation. A, The pressure gradient was measured after 2 weeks of TAC. B, Left, Postmortem measurements of LVW/TL (mg/mm, left) after TAC. Right, Percentage increase in LVW/TL after TAC compared with the mean value of sham-operated mice. Values are means±SD. N=7. C, Representative WGA staining of the LV obtained from Tg-DN-Lats2 and NTg mice after TAC (left) and the relative myocyte cross-sectional area (right). Values are means±SEM obtained from 5 experiments. D, Percentage of TUNEL-positive myocytes. Values are means±SEM obtained from 5 experiments. #P<0.05 vs NTg sham.
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This correction has been made in the current online version of the article.
The authors regret this error.
