Figure 8. fmk did not affect ventricular outward K+ currents and action potential in NLC mice, but it rescued them, which was inhibited or prolonged by p90RSK. A, Outward K+ currents were recorded from NLC (a) and p90RSK-Tg ventricular myocyte (c). Three µmol/L fmk does not affect NLC K+ currents (b), but it rescues them from p90RSK inhibition (d). B, AP was recorded from NLC (a) and p90RSK-Tg ventricular myocyte (c) with a stimulation frequency of 1 Hz. AP is prolonged in p90RSK-expressing ventricular myocyte (c) compared with that in NLC (a). Three µmol/L fmk does not affect NLC AP (b), but it rescues broader p90RSK-Tg AP (c) to normal waveforms (d).
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