Correction
for
Pepine et al., Circ Res 99 (5) 459-461.
Circulation Research. 2006;99:E84
doi: 10.1161/01.RES.0000249804.35956.ba
(Circulation Research. 2006;99:E84.)
© 2006 American Heart Association, Inc.
Correction
In an editorial by Pepine et al. (
Circ Res. 2006;99:459-461),
‘Estrogen and Different Aspects of Vascular Disease in
Women and Men,‘ the name of the third author was omitted.
The correct authorship is Carl J. Pepine, Wilmer W. Nichols
and, Daniel F. Pauly. Additionally, the figure was not reproduced
correctly, resulting in the erroneous presentation of two symbols.
The corrected
figure appears below. The corrected article is
now available at http://circres.ahajournals.org.
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Hypothetical construct based on Montague et al suggests that the activational state of estrogen receptor-alpha (ESR1) governs the vascular smooth muscle (SMC) phenotype. Among men with lower ESR1 expression they identified higher levels of differentiation markers compared with women. However activation of ESR1 in SMCs containing low ESR1 expression reduced differentiation markers and promoted apoptosis. This was accomplished by the authors using lentivirus transduction. Conversely, inhibiting ESR1 in SMCs expressing high levels of interfering RNA (SiRNA). The balance between these mechanisms could contribute to vascular remodeling and plaque instability.
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The Publisher regrets these errors.
Related Article:
-
Estrogen and Different Aspects of Vascular Disease in Women and Men
- Carl J. Pepine, Wilmer W. Nichols, and Daniel F. Pauly
Circ. Res. 2006 99: 459-461.
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