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(Circulation Research. 2005;96:4.)
© 2005 American Heart Association, Inc.

Editorials

Translation, Translation, Translation

Circulation Research in Cardiology’s New Golden Age

Eduardo Marbán

From the Editor in Chief, Circulation Research.

Correspondence to Eduardo Marbán, Johns Hopkins University, Circulation Research Editorial Office, 2700 Lighthouse Point East, Suite 230, Baltimore, MD 21210. E-mail circulation.research@circresearch.com

Key Words: hemodynamics • diagnostics • interventional cardiology • translational research

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Three factors dominate the calculation of real estate value: location, location, and location. As I enter the second half of my editorship of Circulation Research, my reflections pinpoint translation, translation, and translation as the three critical factors dominating the future of our journal. This reflection has its roots in personal ruminations about the field of clinical cardiology and how it has evolved and is evolving today.

Cardiology now finds itself in a defining epochal transition. We are on the threshold of a new Golden Age. Two Golden Ages have preceded that which we are just entering (see Table). In the 1970s and earlier, we experienced the Classical Age. This era was, necessarily, largely descriptive and observational; diseases were classified and codified, taking advantage of newly elucidated principles of fundamental hemodynamics and the development of key diagnostics in the catheterization laboratory, electrocardiography, and echocardiography. Even in this early era, however, Cardiology stood out among nonsurgical subspecialties in that our discipline actually intervened to reverse disease. What better testament can there be to Cardiology’s progressive ethos than the creation of coronary care units (CCUs)? Such units were conceived so that rhythm disturbances could be quickly recognized and treated by cardiopulmonary resuscitation, external defibrillation, or pacemakers. Such therapies, which revolutionized the practice of medicine, were hardly descriptive or observational. But the practice of cardiology relied on basic science only insofar as basic physical principles of pressure, flow, and electricity were concerned; biology was a curiosity, lamentably peripheral to the daily practice . . . [Full Text of this Article]

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