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(Circulation Research. 2002;90:1041.)
© 2002 American Heart Association, Inc.

Editorials

Nonremodeling Properties of Matrix Metalloproteinases

The Platelet Connection

Paul Jurasz, Ada W.Y. Chung, Anna Radomski, Marek W. Radomski

From the Department of Pharmacology, University of Alberta, Edmonton, Canada.

Correspondence to Dr Marek W. Radomski, Department of Pharmacology, University of Alberta, Edmonton, Alberta, 9-50 Medical Sciences Bldg, T6G 2H7, Canada. E-mail marek.radomski@ualberta.ca

Key Words: matrix metalloproteinases • tissue inhibitor of metalloproteinases • platelet function

Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), play an important role as mediators of tissue remodeling under physiological and pathological conditions.¹ Recently, a number of contributions have shown that in addition to chronic remodeling reactions, MMPs are involved in acute biological reactions associated with discrete cell signaling such as regulation of vascular reactivity,^2–4 leukocyte activation,⁵ and platelet function.^6–12 The study by Galt and colleagues, published in this issue of Circulation Research, shows that MMP-1, yet another member of the MMP family of enzymes, primes platelets for aggregation.¹³ They have demonstrated that the outside-in signals delivered by MMP-1 markedly increased the number of protein phosphorylated in platelets. In this respect, MMP-1 acts similar to platelet receptor agonists such as ADP, collagen, and thrombin, which are known to stimulate protein phosphorylation.¹⁴ In addition, this work provides further evidence that some biological functions of platelets are regulated by MMPs.

Blood Platelets

Platelets are small (2 µm in size) anucleate cell elements that are produced by fragmentation of large mother cell megakaryocytes. Although the process of platelet production (thrombopoiesis) is regulated by thrombopoietin, which controls megakaryocyte proliferation, maturation, and platelet generation, some stages of thrombopoiesis are dependent on the activity of MMP-9.¹⁵

Platelets are involved in physiological hemostasis and pathological thrombosis. After accidental or pathological injury, platelets adhere to the damaged portion of the vascular wall initiating an intricate set of reactions that lead via platelet aggregation to the formation of hemostatic plug or occlusive thrombus. Complex platelet metabolic . . . [Full Text of this Article]

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