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(Circulation Research. 2000;87:638.)
© 2000 American Heart Association, Inc.

Editorial

GATA-6: The Proliferation Stops Here

Cell Proliferation in Glomerular Mesangial and Vascular Smooth Muscle Cells

Edward E. Morrisey

From the Department of Medicine, University of Pennsylvania, Philadelphia, Pa.

Correspondence to Edward E. Morrisey, PhD, Department of Medicine, University of Pennsylvania, 953 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104. E-mail emorrise@mail.med.upenn.edu

Key Words: cyclin-dependant kinase inhibitors • transcription factors • cell cycle • differentiation

	Introduction

 
See related article, pages 699–704

GATA-6 belongs to a family of zinc finger transcription factors that have been implicated in various developmental processes, including cell differentiation and proliferation. In this issue of Circulation Research, Nagata et al¹ report that overexpression of GATA-6 in glomerular mesangial cells (GMCs) results in decreased cell proliferation and posttranscriptional upregulation of p21^cip1, a cyclin-dependent kinase (cdk) inhibitor. This finding is especially interesting in light of recent reports showing that GATA-6 regulates cell proliferation via p21^cip1 in vascular smooth muscle cells (VSMCs).² Thus, the present study details a new region of expression for GATA-6 (glomerular mesangial cells) coupled with an important emerging function (regulation of cell proliferation).

All GATA factors activate transcription by binding to the consensus DNA sequence WGATAR (where W is T or A and R is G or A).^{3 4} On the basis of both their amino acid sequence homologies and respective patterns of expression, the 6 vertebrate GATA factors have been classified into 2 subfamilies. Members of the GATA-1/-2/-3 subfamily are known to be important regulators of hematopoietic cell growth and differentiation.⁵ In addition, GATA-1 has been shown to regulate erythroid cell proliferation, whereas GATA-2 seems to regulate multipotential hematopoietic progenitor cell proliferation.^{6 7} GATA-6 was originally characterized as a member of the GATA-4/-5/-6 subfamily of GATA factors, which are expressed in the developing heart and are able to transactivate cardiac-specific promoters, such as cardiac troponin C, atrial natriuretic factor, and -myosin heavy chain, in vitro.⁸ Recent reports of mice containing null . . . [Full Text of this Article]

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