doi: 10.1161/01.RES.0000242563.47507.ce
© 2006 American Heart Association, Inc.
Review |
Trafficking of G Protein–Coupled Receptors
From the Howard Hughes Medical Institute and Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC.
Correspondence to Robert Lefkowitz, Box 3821, Duke University Medical Center, Durham, NC 27710. E-mail lefko001{at}receptor-biol.duke.edu
This Review is part of a thematic series on Microdomains in Cardiovascular Signaling, which includes the following articles:
Caveolae and Caveolins in the Cardiovascular System
Focal Adhesion: Paradigm for a Signaling Nexus
Vesicular Trafficking of Tyrosine Kinase Receptors and Associated Proteins in the Regulation of Signaling and Vascular Function
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of A-Kinase Anchoring Proteins
Trafficking of G Protein–Coupled Receptors
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases
Kathy K. Griendling and David A. Kass Editors
G protein–coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.
Key Words: GPCR trafficking • GPCR kinase (GRK) • ß-arrestin • 7-transmembrane receptors
This article has been cited by other articles:
 |
|
 |
|
  F. A. Caetano, M. H. Lopes, G. N. M. Hajj, C. F. Machado, C. Pinto Arantes, A. C. Magalhaes, M. D. P. B. Vieira, T. A. Americo, A. R. Massensini, S. A. Priola, et al. Endocytosis of Prion Protein Is Required for ERK1/2 Signaling Induced by Stress-Inducible Protein 1 J. Neurosci., June 25, 2008; 28(26): 6691 - 6702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xia, X.-P. Dun, P.-S. Hu, S. Kjaer, K. Zheng, Y. Qian, C. Solen, T. Xu, B. Fredholm, T. Hokfelt, et al. Postendocytotic traffic of the galanin R1 receptor: A lysosomal signal motif on the cytoplasmic terminus PNAS, April 8, 2008; 105(14): 5609 - 5613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Urs, A. P. Kowalczyk, and H. Radhakrishna Different Mechanisms Regulate Lysophosphatidic Acid (LPA)-dependent Versus Phorbol Ester-dependent Internalization of the LPA1 Receptor J. Biol. Chem., February 29, 2008; 283(9): 5249 - 5257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ikeda, M. Hoshijima, and K. R. Chien Toward Biologically Targeted Therapy of Calcium Cycling Defects in Heart Failure Physiology, February 1, 2008; 23(1): 6 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-T. Lin, Y.-J. Lai, N. Makarova, G. Tigyi, and W.-C. Lin The Lysophosphatidic Acid 2 Receptor Mediates Down-regulation of Siva-1 to Promote Cell Survival J. Biol. Chem., December 28, 2007; 282(52): 37759 - 37769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. von Degenfeld, T. S. Wehrman, M. M. Hammer, and H. M. Blau A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals FASEB J, December 1, 2007; 21(14): 3819 - 3826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Perrino, J. N. Schroder, B. Lima, N. Villamizar, J. J. Nienaber, C. A. Milano, and S. V. Naga Prasad Dynamic Regulation of Phosphoinositide 3-Kinase-{gamma} Activity and -Adrenergic Receptor Trafficking in End-Stage Human Heart Failure Circulation, November 27, 2007; 116(22): 2571 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Oakley, J. A. Olivares-Reyes, C. C. Hudson, F. Flores-Vega, F. M. Dautzenberg, and R. L. Hauger Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R209 - R222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Shenoy Seven-Transmembrane Receptors and Ubiquitination Circ. Res., April 27, 2007; 100(8): 1142 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Oo, S. Thangada, M.-T. Wu, C. H. Liu, T. L. Macdonald, K. R. Lynch, C.-Y. Lin, and T. Hla Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor J. Biol. Chem., March 23, 2007; 282(12): 9082 - 9089. [Abstract] [Full Text] [PDF]
|
|