Circulation Research. 2006;98:322-334
doi: 10.1161/01.RES.0000201960.04223.3c
doi: 10.1161/01.RES.0000201960.04223.3c
© 2006 American Heart Association, Inc.
Reviews |
Rho Kinases in Cardiovascular Physiology and Pathophysiology
From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
Correspondence to Pierre Pacaud, Inserm U-533, Faculté des Sciences, 2 rue de la Houssinière, 44322 Nantes cedex 3, France. E-mail pierre.pacaud{at}univ-nantes.fr
This Review is part of a thematic series on The Role of Small GTPases in Cardiovascular Biology, which includes the following articles:
Rho GTPases, Statins and NO
The Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Sheer Stress Response
Rho Kinases in Cardiovascular Physiology and Pathophysiology
Regulation of NADPH Oxidases: the Role of Rac Proteins
Rho GTPases and Signaling by Endothelial Receptors
The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits
Anne Ridley Guest Editor
Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.
Key Words: Rho kinase • cardiovascular diseases • Rho-GTP–binding proteins • signal transduction
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