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(Circulation Research. 2006;98:186.)
© 2006 American Heart Association, Inc.

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Early Growth Response-1 in Cardiovascular Pathobiology

Levon M. Khachigian

From the Centre for Vascular Research, Department of Pathology, University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, Australia.

Correspondence to Levon M. Khachigian, PhD, DSc, Centre for Vascular Research, Department of Pathology, The University of New South Wales, Sydney NSW 2052, Australia. E-mail L.Khachigian{at}unsw.edu.au

Abstract

The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amassing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.

Key Words: Egr-1 • atherosclerosis • vascular injury • angiogenesis • ischemia and ischemia-reperfusion • allograft rejection • cardiac hypertrophy

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