Circulation Research. 2005;97:512-523
doi: 10.1161/01.RES.0000182903.16652.d7
doi: 10.1161/01.RES.0000182903.16652.d7
© 2005 American Heart Association, Inc.
Review |
Endothelial/Pericyte Interactions
From the Vascular Biology Laboratory (A. Armulik, A. Abramsson, C.B.), Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, and Department of Medicine (C.B.), Karolinska Institutet; and the Ludwig Institute for Cancer Research (A. Armulik, C.B.), Stockholm Branch, Stockholm, Sweden.
Correspondence to Dr Christer Betsholtz, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles vag 2, Stockholm SE-171 77, Sweden. E-mail christer.betsholtz{at}mbb.ki.se
This Review is part of a thematic series on Vascular Cell Diversity, which includes the following articles:
Heart Valve Development: Endothelial Cell Signaling and Differentiation
Molecular Determinants of Vascular Smooth Muscle Cell Diversity
Endothelial/Pericyte Interactions
Endothelial-ECM: Biosynthesis, Remodeling, and Functions During Vascular Morphogenesis and Neovessel Stabilization
Joyce Bischoff Guest Editor
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor ß, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.
Key Words: pericyte • transforming growth factor ß • platelet-derived growth factor • angiopoietin sphingosine-1-phosphate
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