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(Circulation Research. 2005;97:1220.)
© 2005 American Heart Association, Inc.

Reviews

Engineering Myocardial Tissue

Thomas Eschenhagen, Wolfram H. Zimmermann

From the Institute of Experimental and Clinical Pharmacology, University Medical Center Hamburg-Eppendorf, Germany.

Correspondence to Thomas Eschenhagen, Martinistrasse 52, D-20246 Hamburg, Germany. E-mail t.eschenhagen{at}uke.uni-hamburg.de

Guest Editor: This Review is part of a thematic series on Cardiovascular Tissue Engineering, which includes the following articles:

Custom Design of the Cardiac Microenvironment with Biomaterials
Heart Valve Tissue Engineering
Engineering Myocardial Tissue
Small-Diameter Artificial Arteries Engineered In Vitro
Regenerative Cardiomyocytes for Cardiovascular Tissue Engineering

Richard T. Lee

To create an artificial heart is one of the most ambitious dreams of the young field of tissue engineering, a dream that, when publicly announced in 1999 (LIFE initiative around M. Sefton), provoked as much compassion as scepticism in the scientific and lay press. Today, it is fair to state that the field is still far away from having built the "bioartificial heart." Nevertheless, substantial progress has been made over the past 10 years, and a realistic perspective exists to create 3-dimensional heart muscle equivalents that may not only serve as experimental models but could also be useful for cardiac regeneration.

Key Words: tissue engineering • heart • stem cells • regeneration

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