doi: 10.1161/01.RES.0000159708.71142.c8
© 2005 American Heart Association, Inc.
Review |
Syndecans
New Kids on the Signaling Block
From the Angiogenesis Research Center, Section of Cardiology, and Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, N.H.
Correspondence to Michael Simons, MD, Section of Cardiology, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756. E-mail michael.simons{at}dartmouth.edu
This Review is part of a thematic series on Angiogenesis, which includes the following articles:
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Bone Marrow–Derived Cells for Enhancing Collateral Development: Mechanisms, Animal Data, and Initial Clinical Experiences
Influence of Mechanical, Cellular, and Molecular Factors on Collateral Artery Growth (Arteriogenesis)
Innate Immunity and Angiogenesis
Syndecans: New Kids on the Signaling Block
Growth Factors and Blood Vessels: Differentiation and Maturation
Ralph Kelly Guest Editor
Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.
Key Words: proteoglycan • angiogenesis • signal transduction • cytoskeleton • migration
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