doi: 10.1161/01.RES.0000153188.68898.ac
© 2005 American Heart Association, Inc.
Reviews |
Innate Immunity and Angiogenesis
From the Genzyme Corporation (K.A.V., R.A.K.), Cambridge Mass; Medizinische Universitätsklinik Würzburg (S.F.), Würzburg, Germany; University of Louvain (O.F.), Brussels, Belgium.
Correspondence to Ralph A. Kelly, MD, Genzyme Corporation, 15 Pleasant Street Connector, PO Box 9322, Framingham, MA 01701-9322. E-mail Ralph.Kelly{at}genzyme.com
This Review is part of a thematic series on Angiogenesis, which includes the following articles:
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Bone Marrow–Derived Cells for Enhancing Collateral Development: Mechanisms, Animal Data, and Initial Clinical Experiences
Influence of Mechanical, Cellular, and Molecular Factors on Collateral Artery Growth (Arteriogenesis)
Innate Immunity and Angiogenesis
Syndecans
Growth Factors and Blood Vessels: Differentiation and Maturation
Ralph Kelly Guest Editor
Activation of an innate immune response is among the first lines of defense after tissue injury. Restoring blood flow to the site of injured tissue is often a necessary prerequisite for mounting an initial immune response to pathogens and for subsequent initiation of a successful repair of wounded tissue. The multiple links among pathogen recognition and suppression, increased angiogenesis, and tissue repair are the topics of this review, which examines of the roles of antimicrobial peptides, mammalian toll-like receptors (TLRs), inflammatory cytokines, and putative "danger" signals, among other signaling pathways, in triggering, sustaining, and then terminating an angiogenic response.
Key Words: angiogenesis • cytokines • HIF • inflammation
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