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(Circulation Research. 2004;95:557.)
© 2004 American Heart Association, Inc.

Report

Phosphorylation Regulates Id3 Function in Vascular Smooth Muscle Cells

Scott T. Forrest, Angela M. Taylor, Ian J. Sarembock, Demetra Perlegas, Coleen A. McNamara

From the Cardiovascular Division, Department of Internal Medicine, and the Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, Va.

Correspondence to Coleen A. McNamara, Cardiovascular Division, Department of Internal Medicine, and the Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908. E-mail cam8c{at}virginia.edu

Abstract

Understanding the mechanisms that regulate cell cycle progression in vascular smooth muscle cells (VSMCs) is key to understanding and modulating vascular lesion formation. Results of the present study provide the first evidence that phosphorylation of the helix-loop-helix factor Id3 in VSMCs occurs in vitro and in vivo and provides a regulatory switch controlling Id3-induced regulation of p21^Cip1 and VSMC growth.

Key Words: muscle • vascular • smooth • cell cycle • helix-loop-helix motifs • phosphorylation

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