Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
Circulation Research. 2004;95:9-20
doi: 10.1161/01.RES.0000135902.99383.6f
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pittenger, M. F.
Right arrow Articles by Martin, B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pittenger, M. F.
Right arrow Articles by Martin, B. J.
Related Collections
Right arrow Other myocardial biology
Right arrow Other heart failure
Right arrow Animal models of human disease
Right arrow Ischemic biology - basic studies
Right arrow Other Treatment
Right arrow Acute myocardial infarction
Right arrow Other Research
(Circulation Research. 2004;95:9.)
© 2004 American Heart Association, Inc.


Reviews

Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics

Mark F. Pittenger, Bradley J. Martin

From Osiris Therapeutics, Inc., Baltimore, Md.

Correspondence to Mark F. Pittenger, PhD, Osiris Therapeutics, Inc., 2001 Aliceanna St, Baltimore, MD 21231. E-mail mpittenger{at}osiristx.com

This Review is part of a thematic series on Stem Cells, which includes the following articles:

Differentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes

Derivation and Potential Applications of Human Embryonic Stem Cells

Stem Cells for Myocardial Regeneration

Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure

Neural Stem Cells: An Overview

Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics

Therapeutics and Use of Stem Cells
Roberto Bolli Editors

Mesenchymal stem cells (MSCs) represent a stem cell population present in adult tissues that can be isolated, expanded in culture, and characterized in vitro and in vivo. MSCs differentiate readily into chondrocytes, adipocytes, osteocytes, and they can support hematopoietic stem cells or embryonic stem cells in culture. Evidence suggests MSCs can also express phenotypic characteristics of endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells. When introduced into the infarcted heart, MSCs prevent deleterious remodeling and improve recovery, although further understanding of MSC differentiation in the cardiac scar tissue is still needed. MSCs have been injected directly into the infarct, or they have been administered intravenously and seen to home to the site of injury. Examination of the interaction of allogeneic MSCs with cells of the immune system indicates little rejection by T cells. Persistence of allogeneic MSCs in vivo suggests their potential "off the shelf" therapeutic use for multiple recipients. Clinical use of cultured human MSCs (hMSCs) has begun for cancer patients, and recipients have received autologous or allogeneic MSCs. Research continues to support the desirable traits of MSCs for development of cellular therapeutics for many tissues, including the cardiovascular system. In summary, hMSCs isolated from adult bone marrow provide an excellent model for development of stem cell therapeutics, and their potential use in the cardiovascular system is currently under investigation in the laboratory and clinical settings.


Key Words: cardiomyoplasty • mesenchymal • cell therapy • stem cell




This article has been cited by other articles:


Home page
Ann. Thorac. Surg.Home page
J. L. Herrmann, A. M. Abarbanell, B. R. Weil, Y. Wang, M. Wang, J. Tan, and D. R. Meldrum
Cell-based therapy for ischemic heart disease: a clinical update.
Ann. Thorac. Surg., November 1, 2009; 88(5): 1714 - 1722.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
T. S. Chen, R. C. Lai, M. M. Lee, A. B. H. Choo, C. N. Lee, and S. K. Lim
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
Nucleic Acids Res., October 22, 2009; (2009) gkp857v1.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
A. M. Abarbanell, A. C. Coffey, J. W. Fehrenbacher, D. J. Beckman, J. L. Herrmann, B. Weil, and D. R. Meldrum
Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart.
Ann. Thorac. Surg., September 1, 2009; 88(3): 1036 - 1043.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
M. Jumabay, R. Zhang, Y. Yao, J. I. Goldhaber, and K. I. Bostrom
Spontaneously beating cardiomyocytes derived from white mature adipocytes
Cardiovasc Res, August 21, 2009; (2009) cvp267v2.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
K. W. Park, H. Waki, W.-K. Kim, B. S. J. Davies, S. G. Young, F. Parhami, and P. Tontonoz
The Small Molecule Phenamil Induces Osteoblast Differentiation and Mineralization
Mol. Cell. Biol., July 15, 2009; 29(14): 3905 - 3914.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
D. E. Discher, D. J. Mooney, and P. W. Zandstra
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Science, June 26, 2009; 324(5935): 1673 - 1677.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
Z. Bagi and G. Kaley
Where Have All the Stem Cells Gone?
Circ. Res., February 13, 2009; 104(3): 280 - 281.
[Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
F. Nicolini and T. Gherli
Alternatives to transplantation in the surgical therapy for heart failure
Eur. J. Cardiothorac. Surg., February 1, 2009; 35(2): 214 - 228.
[Abstract] [Full Text] [PDF]


Home page
Reproductive SciencesHome page
Hongling Du and H. S. Taylor
Reviews: Stem Cells and Female Reproduction
Reproductive Sciences, February 1, 2009; 16(2): 126 - 139.
[Abstract] [PDF]


Home page
J EndocrinolHome page
J. N Artaza and K. C Norris
Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells
J. Endocrinol., February 1, 2009; 200(2): 207 - 221.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
J. Jin, S. I. Jeong, Y. M. Shin, K. S. Lim, H. s. Shin, Y. M. Lee, H. C. Koh, and K.-S. Kim
Transplantation of mesenchymal stem cells within a poly(lactide-co-{varepsilon}-caprolactone) scaffold improves cardiac function in a rat myocardial infarction model
Eur J Heart Fail, February 1, 2009; 11(2): 147 - 153.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. P. Alfaro, M. Pagni, A. Vincent, J. Atkinson, M. F. Hill, J. Cates, J. M. Davidson, J. Rottman, E. Lee, and P. P. Young
The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair
PNAS, November 25, 2008; 105(47): 18366 - 18371.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
M. Gnecchi, Z. Zhang, A. Ni, and V. J. Dzau
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Circ. Res., November 21, 2008; 103(11): 1204 - 1219.
[Abstract] [Full Text] [PDF]


Home page
JNMHome page
V. Roelants, D. Labar, C. de Meester, X. Havaux, A. Tabilio, S. S. Gambhir, M. Di Ianni, A. Bol, L. Bertrand, and J.-L. Vanoverschelde
Comparison Between Adenoviral and Retroviral Vectors for the Transduction of the Thymidine Kinase PET Reporter Gene in Rat Mesenchymal Stem Cells
J. Nucl. Med., November 1, 2008; 49(11): 1836 - 1844.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
B. Zeng, H. Chen, C. Zhu, X. Ren, G. Lin, and F. Cao
Effects of combined mesenchymal stem cells and heme oxygenase-1 therapy on cardiac performance
Eur. J. Cardiothorac. Surg., October 1, 2008; 34(4): 850 - 856.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Carr, D. J. Stuckey, L. Tatton, D. J. Tyler, S. J. M. Hale, D. Sweeney, J. E. Schneider, E. Martin-Rendon, G. K. Radda, S. E. Harding, et al.
Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H533 - H542.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
D. A. Pijnappels, M. J. Schalij, A. A. Ramkisoensing, J. van Tuyn, A. A.F. de Vries, A. van der Laarse, D. L. Ypey, and D. E. Atsma
Forced Alignment of Mesenchymal Stem Cells Undergoing Cardiomyogenic Differentiation Affects Functional Integration With Cardiomyocyte Cultures
Circ. Res., July 18, 2008; 103(2): 167 - 176.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Ng, S. Boucher, S. Koh, K. S. R. Sastry, L. Chase, U. Lakshmipathy, C. Choong, Z. Yang, M. C. Vemuri, M. S. Rao, et al.
PDGF, TGF-{beta}, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages
Blood, July 15, 2008; 112(2): 295 - 307.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
R. Abdi, P. Fiorina, C. N. Adra, M. Atkinson, and M. H. Sayegh
Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes
Diabetes, July 1, 2008; 57(7): 1759 - 1767.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
D. L. Coutu, J. H. Wu, A. Monette, G.-E. Rivard, M. D. Blostein, and J. Galipeau
Periostin, a Member of a Novel Family of Vitamin K-dependent Proteins, Is Expressed by Mesenchymal Stromal Cells
J. Biol. Chem., June 27, 2008; 283(26): 17991 - 18001.
[Abstract] [Full Text] [PDF]


Home page
Vasc MedHome page
C Kalka and I. Baumgartner
Gene and stem cell therapy in peripheral arterial occlusive disease
Vascular Medicine, May 1, 2008; 13(2): 157 - 172.
[Abstract] [PDF]


Home page
CirculationHome page
M. P. Flaherty, A. Abdel-Latif, Q. Li, G. Hunt, S. Ranjan, Q. Ou, X.-L. Tang, R. K. Johnson, R. Bolli, and B. Dawn
Noncanonical Wnt11 Signaling Is Sufficient to Induce Cardiomyogenic Differentiation in Unfractionated Bone Marrow Mononuclear Cells
Circulation, April 29, 2008; 117(17): 2241 - 2252.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
C. A. Beltrami
Life is plastic
Blood, March 1, 2008; 111(5): 2942 - 2943.
[Full Text] [PDF]


Home page
Rheumatology (Oxford)Home page
E. Jones and D. McGonagle
Human bone marrow mesenchymal stem cells in vivo
Rheumatology, February 1, 2008; 47(2): 126 - 131.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J. Shujia, H. K. Haider, N. M. Idris, G. Lu, and M. Ashraf
Stable therapeutic effects of mesenchymal stem cell-based multiple gene delivery for cardiac repair
Cardiovasc Res, February 1, 2008; 77(3): 525 - 533.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
H. Zhang, P. Song, Y. Tang, X.-l. Zhang, S.-h. Zhao, Y.-j. Wei, and S.-s. Hu
Injection of bone marrow mesenchymal stem cells in the borderline area of infarcted myocardium: heart status and cell distribution.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1234 - 1240.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. P. Beltrami, D. Cesselli, N. Bergamin, P. Marcon, S. Rigo, E. Puppato, F. D'Aurizio, R. Verardo, S. Piazza, A. Pignatelli, et al.
Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow)
Blood, November 1, 2007; 110(9): 3438 - 3446.
[Abstract] [Full Text] [PDF]


Home page
Rheumatology (Oxford)Home page
A. English, E. A. Jones, D. Corscadden, K. Henshaw, T. Chapman, P. Emery, and D. McGonagle
A comparative assessment of cartilage and joint fat pad as a potential source of cells for autologous therapy development in knee osteoarthritis
Rheumatology, November 1, 2007; 46(11): 1676 - 1683.
[Abstract] [Full Text] [PDF]


Home page
Phil Trans R Soc BHome page
P. Batten, N. A Rosenthal, and M. H Yacoub
Immune response to stem cells and strategies to induce tolerance
Phil Trans R Soc B, August 29, 2007; 362(1484): 1343 - 1356.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. Breitbach, T. Bostani, W. Roell, Y. Xia, O. Dewald, J. M. Nygren, J. W. U. Fries, K. Tiemann, H. Bohlen, J. Hescheler, et al.
Potential risks of bone marrow cell transplantation into infarcted hearts
Blood, August 15, 2007; 110(4): 1362 - 1369.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
A. Vincentelli, F. Wautot, F. Juthier, O. Fouquet, D. Corseaux, S. Marechaux, T. Le Tourneau, O. Fabre, S. Susen, E. Van Belle, et al.
In vivo autologous recellularization of a tissue-engineered heart valve: Are bone marrow mesenchymal stem cells the best candidates?
J. Thorac. Cardiovasc. Surg., August 1, 2007; 134(2): 424 - 432.
[Abstract] [Full Text] [PDF]


Home page
RadiologyHome page
R. Schafer, R. Kehlbach, J. Wiskirchen, R. Bantleon, J. Pintaske, B. R. Brehm, A. Gerber, H. Wolburg, C. D. Claussen, and H. Northoff
Transferrin Receptor Upregulation: In Vitro Labeling of Rat Mesenchymal Stem Cells with Superparamagnetic Iron Oxide
Radiology, August 1, 2007; 244(2): 514 - 523.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
J. E. Ip, Y. Wu, J. Huang, L. Zhang, R. E. Pratt, and V. J. Dzau
Mesenchymal Stem Cells Use Integrin beta1 Not CXC Chemokine Receptor 4 for Myocardial Migration and Engraftment
Mol. Biol. Cell, August 1, 2007; 18(8): 2873 - 2882.
[Abstract] [Full Text] [PDF]


Home page
haematolHome page
M. Shi, J. Li, L. Liao, B. Chen, B. Li, L. Chen, H. Jia, and R. C. Zhao
Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice
Haematologica, July 1, 2007; 92(7): 897 - 904.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Zhao and S. Ding
A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells
PNAS, June 5, 2007; 104(23): 9673 - 9678.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
K. Tateishi, E. Ashihara, N. Takehara, T. Nomura, S. Honsho, T. Nakagami, S. Morikawa, T. Takahashi, T. Ueyama, H. Matsubara, et al.
Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration
J. Cell Sci., May 15, 2007; 120(10): 1791 - 1800.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. Ventura, S. Cantoni, F. Bianchi, V. Lionetti, C. Cavallini, I. Scarlata, L. Foroni, M. Maioli, L. Bonsi, F. Alviano, et al.
Hyaluronan Mixed Esters of Butyric and Retinoic Acid Drive Cardiac and Endothelial Fate in Term Placenta Human Mesenchymal Stem Cells and Enhance Cardiac Repair in Infarcted Rat Hearts
J. Biol. Chem., May 11, 2007; 282(19): 14243 - 14252.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. J. Muller-Borer, W. E. Cascio, G. L. Esch, H.-S. Kim, W. B. Coleman, J. W. Grisham, P. A. W. Anderson, and N. N. Malouf
Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells
PNAS, March 6, 2007; 104(10): 3877 - 3882.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
B. Dawn and R. Bolli
Bone marrow for cardiac repair: the importance of characterizing the phenotype and function of injected cells
Eur. Heart J., March 5, 2007; (2007) ehm009v1.
[Full Text] [PDF]


Home page
BloodHome page
E. J. Gang, D. Bosnakovski, C. A. Figueiredo, J. W. Visser, and R. C. R. Perlingeiro
SSEA-4 identifies mesenchymal stem cells from bone marrow
Blood, February 15, 2007; 109(4): 1743 - 1751.
[Abstract] [Full Text] [PDF]


Home page
JBJSHome page
A. K.S. Chong, A. D. Ang, J. C.H. Goh, J. H.P. Hui, A. Y.T. Lim, E. H. Lee, and B. H. Lim
Bone Marrow-Derived Mesenchymal Stem Cells Influence Early Tendon-Healing in a Rabbit Achilles Tendon Model
J. Bone Joint Surg. Am., January 1, 2007; 89(1): 74 - 81.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. Bruno, B. Bussolati, C. Grange, F. Collino, M. E. Graziano, U. Ferrando, and G. Camussi
CD133+ Renal Progenitor Cells Contribute to Tumor Angiogenesis
Am. J. Pathol., December 1, 2006; 169(6): 2223 - 2235.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. F. Zhou, M. Bosch-Marce, H. Okuyama, B. Krishnamachary, H. Kimura, L. Zhang, D. L. Huso, and G. L. Semenza
Spontaneous Transformation of Cultured Mouse Bone Marrow-Derived Stromal Cells.
Cancer Res., November 15, 2006; 66(22): 10849 - 10854.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
D. A. Pijnappels, M. J. Schalij, J. van Tuyn, D. L. Ypey, A. A.F. de Vries, E. E. van der Wall, A. van der Laarse, and D. E. Atsma
Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling
Cardiovasc Res, November 1, 2006; 72(2): 282 - 291.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
K.-L. Ang, L. Takura Shenje, L. Srinivasan, and M. Galinanes
Repair of the damaged heart by bone marrow cells: from experimental evidence to clinical hope.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1549 - 1558.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
S. Roura, J. Farre, C. Soler-Botija, A. Llach, L. Hove-Madsen, J. J. Cairo, F. Godia, J. Cinca, and A. Bayes-Genis
Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells
Eur J Heart Fail, October 1, 2006; 8(6): 555 - 563.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
S. Jiang, H. Kh. Haider, N. M. Idris, A. Salim, and M. Ashraf
Supportive Interaction Between Cell Survival Signaling and Angiocompetent Factors Enhances Donor Cell Survival and Promotes Angiomyogenesis for Cardiac Repair
Circ. Res., September 29, 2006; 99(7): 776 - 784.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
L. Zeng, Q. Xiao, A. Margariti, Z. Zhang, A. Zampetaki, S. Patel, M. C. Capogrossi, Y. Hu, and Q. Xu
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
J. Cell Biol., September 25, 2006; 174(7): 1059 - 1069.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. P. Martens, M. Argenziano, and M. C. Oz
New Technology for Surgical Coronary Revascularization
Circulation, August 8, 2006; 114(6): 606 - 614.
[Full Text] [PDF]


Home page
CirculationHome page
A. J. Boyle, S. P. Schulman, and J. M. Hare
Stem Cell Therapy for Cardiac Repair: Ready for the Next Step
Circulation, July 25, 2006; 114(4): 339 - 352.
[Full Text] [PDF]


Home page
CirculationHome page
P. Oettgen
Cardiac Stem Cell Therapy: Need for Optimization of Efficacy and Safety Monitoring
Circulation, July 25, 2006; 114(4): 353 - 358.
[Full Text] [PDF]


Home page
CirculationHome page
M. Hendrikx, K. Hensen, C. Clijsters, H. Jongen, R. Koninckx, E. Bijnens, M. Ingels, A. Jacobs, R. Geukens, P. Dendale, et al.
Recovery of Regional but Not Global Contractile Function by the Direct Intramyocardial Autologous Bone Marrow Transplantation: Results From a Randomized Controlled Clinical Trial
Circulation, July 4, 2006; 114(1_suppl): I-101 - I-107.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Okuyama, B. Krishnamachary, Y. F. Zhou, H. Nagasawa, M. Bosch-Marce, and G. L. Semenza
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
J. Biol. Chem., June 2, 2006; 281(22): 15554 - 15563.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
Y Wang, H E Johnsen, S Mortensen, L Bindslev, R Sejersten Ripa, M Haack-Sorensen, E Jorgensen, W Fang, and J Kastrup
Changes in circulating mesenchymal stem cells, stem cell homing factor, and vascular growth factors in patients with acute ST elevation myocardial infarction treated with primary percutaneous coronary intervention
Heart, June 1, 2006; 92(6): 768 - 774.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
A. Y. Khakoo, S. Pati, S. A. Anderson, W. Reid, M. F. Elshal, I. I. Rovira, A. T. Nguyen, D. Malide, C. A. Combs, G. Hall, et al.
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
J. Exp. Med., May 15, 2006; 203(5): 1235 - 1247.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
C. E. Murry, H. Reinecke, and L. M. Pabon
Regeneration Gaps: Observations on Stem Cells and Cardiac Repair
J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1777 - 1785.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky
A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction
Eur. Heart J., May 1, 2006; 27(9): 1114 - 1122.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
L. Zentilin, S. Tafuro, S. Zacchigna, N. Arsic, L. Pattarini, M. Sinigaglia, and M. Giacca
Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels
Blood, May 1, 2006; 107(9): 3546 - 3554.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
K. Fukuda and S. Yuasa
Stem Cells as a Source of Regenerative Cardiomyocytes
Circ. Res., April 28, 2006; 98(8): 1002 - 1013.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
M. Gnecchi, H. He, N. Noiseux, O. D. Liang, L. Zhang, F. Morello, H. Mu, L. G. Melo, R. E. Pratt, J. S. Ingwall, et al.
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
FASEB J, April 1, 2006; 20(6): 661 - 669.
[Abstract] [Full Text] [PDF]


Home page
aacredbookHome page
P. J. Simmons, B. Short, and N. Brouard
The Properties of Prospectively Isolated Mesenchymal Stem Cells from Man and Mouse
Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 334 - 338.
[Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
V. F. M. Segers, I. Van Riet, L. J. Andries, K. Lemmens, M. J. Demolder, A. J. M. L. De Becker, M. M. Kockx, and G. W. De Keulenaer
Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms
Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1370 - H1377.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. Stagg, S. Pommey, N. Eliopoulos, and J. Galipeau
Interferon-{gamma}-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell
Blood, March 15, 2006; 107(6): 2570 - 2577.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
G. M. Spaggiari, A. Capobianco, S. Becchetti, M. C. Mingari, and L. Moretta
Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
Blood, February 15, 2006; 107(4): 1484 - 1490.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
Y. Misao, G. Takemura, M. Arai, S. Sato, K. Suzuki, S. Miyata, K.-i. Kosai, S. Minatoguchi, T. Fujiwara, and H. Fujiwara
Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation
Cardiovasc Res, February 1, 2006; 69(2): 476 - 490.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. L. Spees, S. D. Olson, M. J. Whitney, and D. J. Prockop
Mitochondrial transfer between cells can rescue aerobic respiration
PNAS, January 31, 2006; 103(5): 1283 - 1288.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. Riggi, L. Cironi, P. Provero, M.-L. Suva, K. Kaloulis, C. Garcia-Echeverria, F. Hoffmann, A. Trumpp, and I. Stamenkovic
Development of Ewing's Sarcoma from Primary Bone Marrow-Derived Mesenchymal Progenitor Cells
Cancer Res., December 15, 2005; 65(24): 11459 - 11468.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. R. Munoz, B. R. Stoutenger, A. P. Robinson, J. L. Spees, and D. J. Prockop
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice
PNAS, December 13, 2005; 102(50): 18171 - 18176.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
S. L.M.A. Beeres, D. E. Atsma, A. van der Laarse, D. A. Pijnappels, J. van Tuyn, W. E. Fibbe, A. A.F. de Vries, D. L. Ypey, E. E. van der Wall, and M. J. Schalij
Human Adult Bone Marrow Mesenchymal Stem Cells Repair Experimental Conduction Block in Rat Cardiomyocyte Cultures
J. Am. Coll. Cardiol., November 15, 2005; 46(10): 1943 - 1952.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
C. E. Murry, L. J. Field, and P. Menasche
Cell-Based Cardiac Repair: Reflections at the 10-Year Point
Circulation, November 15, 2005; 112(20): 3174 - 3183.
[Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
S. Sartore, M. Lenzi, A. Angelini, A. Chiavegato, L. Gasparotto, P. D. Coppi, R. Bianco, and G. Gerosa
Amniotic mesenchymal cells autotransplanted in a porcine model of cardiac ischemia do not differentiate to cardiogenic phenotypes
Eur. J. Cardiothorac. Surg., November 1, 2005; 28(5): 677 - 684.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
S. Fazel, L. Chen, R. D. Weisel, D. Angoulvant, C. Seneviratne, A. Fazel, P. Cheung, J. Lam, P. W.M. Fedak, T. M. Yau, et al.
Cell transplantation preserves cardiac function after infarction by infarct stabilization: Augmentation by stem cell factor
J. Thorac. Cardiovasc. Surg., November 1, 2005; 130(5): 1310 - 1310.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
V. J. Dzau, M. Gnecchi, and A. S. Pachori
Enhancing Stem Cell Therapy Through Genetic Modification
J. Am. Coll. Cardiol., October 4, 2005; 46(7): 1351 - 1353.
[Full Text] [PDF]


Home page
Physiol. Rev.Home page
A. Leri, J. Kajstura, and P. Anversa
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Physiol Rev, October 1, 2005; 85(4): 1373 - 1416.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. L. Kraitchman, M. Tatsumi, W. D. Gilson, T. Ishimori, D. Kedziorek, P. Walczak, W. P. Segars, H. H. Chen, D. Fritzges, I. Izbudak, et al.
Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction
Circulation, September 6, 2005; 112(10): 1451 - 1461.
[Abstract] [Full Text] [PDF]


Home page
Evid Based Complement Alternat MedHome page
C. Ventura
CAM and Cell Fate Targeting: Molecular and Energetic Insights into Cell Growth and Differentiation
Evid. Based Complement. Altern. Med., September 1, 2005; 2(3): 277 - 283.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
H. Wang, G. M. Riha, S. Yan, M. Li, H. Chai, H. Yang, Q. Yao, and C. Chen
Shear Stress Induces Endothelial Differentiation From a Murine Embryonic Mesenchymal Progenitor Cell Line
Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1817 - 1823.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. C. Amado, A. P. Saliaris, K. H. Schuleri, M. St. John, J.-S. Xie, S. Cattaneo, D. J. Durand, T. Fitton, J. Q. Kuang, G. Stewart, et al.
Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
PNAS, August 9, 2005; 102(32): 11474 - 11479.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
M. Siepe, C. Heilmann, P. von Samson, P. Menasche, and F. Beyersdorf
Stem cell research and cell transplantation for myocardial regeneration
Eur. J. Cardiothorac. Surg., August 1, 2005; 28(2): 318 - 324.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
C. Ventura
Forced myocardin expression primes cardiac and smooth muscle transcription patterning in human mesenchymal stem cells
Cardiovasc Res, August 1, 2005; 67(2): 182 - 183.
[Full Text] [PDF]


Home page
Cardiovasc ResHome page
J. van Tuyn, S. Knaan-Shanzer, M. J.M. van de Watering, M. de Graaf, A. van der Laarse, M. J. Schalij, E. E. van der Wall, A. A.F. de Vries, and D. E. Atsma
Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin
Cardiovasc Res, August 1, 2005; 67(2): 245 - 255.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
K. C. Wollert and H. Drexler
Mesenchymal Stem Cells for Myocardial Infarction: Promises and Pitfalls
Circulation, July 12, 2005; 112(2): 151 - 153.
[Full Text] [PDF]


Home page
CirculationHome page
W. Dai, S. L. Hale, B. J. Martin, J.-Q. Kuang, J. S. Dow, L. E. Wold, and R. A. Kloner
Allogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat Myocardium: Short- and Long-Term Effects
Circulation, July 12, 2005; 112(2): 214 - 223.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
F. Togel, Z. Hu, K. Weiss, J. Isaac, C. Lange, C. Westenfelder, T. Stasko, M.D. Brown, J.A. Carucci, S. Euvrard, et al.
Amelioration of Acute Renal Failure by Stem Cell Therapy--Paracrine Secretion Versus Transdifferentiation into Resident Cells: Administered Mesenchymal Stem Cells Protect against Ischemic Acute Renal Failure through Differentiation-Independent Mechanisms. Am J Physiol Renal Physiol E-pub February 15, 2005
J. Am. Soc. Nephrol., May 1, 2005; 16(5): 1153 - 1163.
[Full Text] [PDF]


Home page
BloodHome page
S. Aggarwal and M. F. Pittenger
Human mesenchymal stem cells modulate allogeneic immune cell responses
Blood, February 15, 2005; 105(4): 1815 - 1822.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
K. C. Wollert and H. Drexler
Clinical Applications of Stem Cells for the Heart
Circ. Res., February 4, 2005; 96(2): 151 - 163.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
R. F. Klees, R. M. Salasznyk, K. Kingsley, W. A. Williams, A. Boskey, and G. E. Plopper
Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-dependent Pathway
Mol. Biol. Cell, February 1, 2005; 16(2): 881 - 890.
[Abstract] [Full Text] [PDF]