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(Circulation Research. 2004;94:874.)
© 2004 American Heart Association, Inc.

Reviews

Regulation of Ion Channel Expression

Barbara Rosati, David McKinnon

From the Departments of Physiology and Biophysics (B.R.) and Neurobiology and Behavior (D.M.), Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, NY.

Correspondence to David McKinnon, Department of Physiology and Biophysics, BST Room 124, Level 6, SUNY, Stony Brook, NY 11794-8661. E-mail dmckinnon{at}notes.cc.sunysb.edu

This Review is part of a thematic series on the Biology of Cardiac Arrhythmias, which includes the following articles:



Antiarrhythmic Drug Target Choices and Screening
Inherited Arrhythmogenic Diseases: The Complexity Beyond Monogenic Disorders
Genomics in Sudden Cardiac Death
Regulation of Ion Channel Expression
Ion Channel Protein Processing Computational Insights: Chaos and Wave Theory
Gene Therapy and Cell Therapy of Cardiac Arrhythmias


This series is in honor of Harry A. Fozzard, 8th Editor of Circulation Research.
Gordon Tomaselli Editors

A potentially important mechanism controlling ion channel expression is homeostatic regulation, which can act to maintain a stable electrophysiological phenotype in cardiac myocytes as well as to provide plasticity in response to genetic, pathological, or pharmacological insults. The capabilities and limitations of the homeostatic regulatory mechanisms that contribute to the control of cardiac ion channel expression are the primary topic of this review.

Key Words: heart • ion channel • gene regulation

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