Circulation Research. 2004;94:724-734
doi: 10.1161/01.RES.0000122383.60368.24
doi: 10.1161/01.RES.0000122383.60368.24
© 2004 American Heart Association, Inc.
Reviews |
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
From the Children’s Hospital of Oakland Research Institute (J.D.S.), Oakland, Calif; and Center for Vascular Biology (T.H.), Department of Cell Biology, University of Connecticut Health Center, Farmington, Conn.
Correspondence to Timothy Hla, Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030-3501. E-mail hla{at}nso2.uchc.edu
This Review is part of a thematic series on Lipid Signaling in Vascular Cells, which includes the following articles:
Phospholipase A2 in Vascular Disease
Prostaglandin H Synthase and Vascular Function
Cytochrome P450 Enzymes in Vascular Homeostasis
Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Ingrid Fleming Guest Editor
Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is now recognized as a potent modulator of cell regulation. In vertebrates, S1P interacts with cell surface G protein-coupled receptors of the EDG family and induces profound effects in a variety of organ systems. Indeed, an S1P receptor agonist is undergoing clinical trials to combat immune-mediated transplant rejection. Recent information on S1P receptor biology suggests potential utility in the control of cardiovascular processes, including angiogenesis, vascular permeability, arteriogenesis, and vasospasm. However, studies from diverse invertebrates, such as yeast, Dictyostelium, Drosophila, and Caenorhabditis elegans have shown that S1P is involved in important regulatory functions in the apparent absence of EDG S1P receptor homologues. Metabolic pathways of S1P synthesis, degradation, and release have recently been described at the molecular level. Genetic and biochemical studies of these enzymes have illuminated the importance of S1P signaling systems both inside and outside of cells. The revelation of receptor-dependent pathways, as well as novel metabolic/intracellular pathways has provided new biological insights and may ultimately pave the way for the development of novel therapeutic approaches for cardiovascular diseases.
Key Words: sphingolipid mediators • sphingosine kinase • sphingosine 1-phosphate phosphatase • sphingosine 1-phosphate lyase • sphingosine 1-phosphate receptors
This article has been cited by other articles:
 |
|
 |
|
  H. Hayashi, H. Nakagami, Y. Takami, H. Koriyama, M. Mori, K. Tamai, J. Sun, K. Nagao, R. Morishita, and Y. Kaneda FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1 Arterioscler. Thromb. Vasc. Biol., June 1, 2009; 29(6): 909 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Skoura and T. Hla Regulation of vascular physiology and pathology by the S1P2 receptor subtype Cardiovasc Res, May 1, 2009; 82(2): 221 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Michaelson, S. Zauner, J. E. Markham, R. P. Haslam, R. Desikan, S. Mugford, S. Albrecht, D. Warnecke, P. Sperling, E. Heinz, et al. Functional Characterization of a Higher Plant Sphingolipid {Delta}4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis Plant Physiology, January 1, 2009; 149(1): 487 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Coste, C. Brenneis, B. Linke, S. Pierre, C. Maeurer, W. Becker, H. Schmidt, W. Gao, G. Geisslinger, and K. Scholich Sphingosine 1-Phosphate Modulates Spinal Nociceptive Processing J. Biol. Chem., November 21, 2008; 283(47): 32442 - 32451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tauseef, V. Kini, N. Knezevic, M. Brannan, R. Ramchandaran, H. Fyrst, J. Saba, S. M. Vogel, A. B. Malik, and D. Mehta Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells Circ. Res., November 7, 2008; 103(10): 1164 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Shida, X. Fang, T. Kordula, K. Takabe, S. Lepine, S. E. Alvarez, S. Milstien, and S. Spiegel Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion Cancer Res., August 15, 2008; 68(16): 6569 - 6577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Duenas, M. Aceves, I. Fernandez-Pisonero, C. Gomez, A. Orduna, M. S. Crespo, and C. Garcia-Rodriguez Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate Cardiovasc Res, August 1, 2008; 79(3): 537 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bu, B. Kapanadze, T. Hsu, and M. Trojanowska Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-{beta}/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway J. Biol. Chem., July 11, 2008; 283(28): 19593 - 19602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Lebman and S. Spiegel Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling J. Lipid Res., July 1, 2008; 49(7): 1388 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Strochlic, A. Dwivedy, F. P. G. van Horck, J. Falk, and C. E. Holt A role for S1P signalling in axon guidance in the Xenopus visual system Development, January 15, 2008; 135(2): 333 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bandhuvula, H. Fyrst, and J. D. Saba A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity J. Lipid Res., December 1, 2007; 48(12): 2769 - 2778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimizu, T. Nakazawa, A. Cho, F. Dastvan, D. Shilling, G. Daum, and M. A. Reidy Sphingosine 1-Phosphate Receptor 2 Negatively Regulates Neointimal Formation in Mouse Arteries Circ. Res., November 9, 2007; 101(10): 995 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Sankala, N. C. Hait, S. W. Paugh, D. Shida, S. Lepine, L. W. Elmore, P. Dent, S. Milstien, and S. Spiegel Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin Cancer Res., November 1, 2007; 67(21): 10466 - 10474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, N. Honbo, E. J. Goetzl, K. Chatterjee, J. S. Karliner, and M. O. Gray Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3150 - H3158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brizuela, M. Rabano, P. Gangoiti, N. Narbona, J. M. Macarulla, M. Trueba, and A. Gomez-Munoz Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways J. Lipid Res., October 1, 2007; 48(10): 2264 - 2274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Damirin, H. Tomura, M. Komachi, J.-P. Liu, C. Mogi, M. Tobo, J.-Q. Wang, T. Kimura, A. Kuwabara, Y. Yamazaki, et al. Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2513 - H2522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Xia Letter by Xia Regarding Article, "High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/Reperfusion Injury In Vivo via the S1P3 Lysophospholipid Receptor" Circulation, April 10, 2007; 115(14): e393 - e393. [Full Text] [PDF]
|
|
|
|
 |
|
 I. D. Jung, J. S. Lee, Y. J. Kim, Y.-I. Jeong, C.-M. Lee, T. Baumruker, A. Billlich, Y. Banno, M. G. Lee, S.-C. Ahn, et al. Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells Int. Immunol., April 1, 2007; 19(4): 411 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tao, J. Zhang, D. A. Vessey, N. Honbo, and J. S. Karliner Deletion of the Sphingosine Kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes Cardiovasc Res, April 1, 2007; 74(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Oo, S. Thangada, M.-T. Wu, C. H. Liu, T. L. Macdonald, K. R. Lynch, C.-Y. Lin, and T. Hla Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor J. Biol. Chem., March 23, 2007; 282(12): 9082 - 9089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Herr, N. Grillet, M. Schwander, R. Rivera, U. Muller, and J. Chun Sphingosine 1-Phosphate (S1P) Signaling Is Required for Maintenance of Hair Cells Mainly via Activation of S1P2 J. Neurosci., February 7, 2007; 27(6): 1474 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Walter, U. Rochwalsky, J. Reinhold, F. Seeger, A. Aicher, C. Urbich, I. Spyridopoulos, J. Chun, V. Brinkmann, P. Keul, et al. Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-Dependent Signaling Pathway via the S1P3 Receptor Arterioscler. Thromb. Vasc. Biol., February 1, 2007; 27(2): 275 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Brace, R. L. Lester, R. C. Dickson, and C. M. Rudin SVF1 Regulates Cell Survival by Affecting Sphingolipid Metabolism in Saccharomyces cerevisiae Genetics, January 1, 2007; 175(1): 65 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Oskouian, P. Sooriyakumaran, A. D. Borowsky, A. Crans, L. Dillard-Telm, Y. Y. Tam, P. Bandhuvula, and J. D. Saba Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer PNAS, November 14, 2006; 103(46): 17384 - 17389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mitra, C. A. Oskeritzian, S. G. Payne, M. A. Beaven, S. Milstien, and S. Spiegel Role of ABCC1 in export of sphingosine-1-phosphate from mast cells PNAS, October 31, 2006; 103(44): 16394 - 16399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kohno, M. Momoi, M. L. Oo, J.-H. Paik, Y.-M. Lee, K. Venkataraman, Y. Ai, A. P. Ristimaki, H. Fyrst, H. Sano, et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell. Biol., October 1, 2006; 26(19): 7211 - 7223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C.M. Mulders, M. C. Hendriks-Balk, M.-J. Mathy, M. C. Michel, A. E. Alewijnse, and S. L.M. Peters Sphingosine Kinase-Dependent Activation of Endothelial Nitric Oxide Synthase by Angiotensin II Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 2043 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Giussani, M. Maceyka, H. Le Stunff, A. Mikami, S. Lepine, E. Wang, S. Kelly, A. H. Merrill Jr., S. Milstien, and S. Spiegel Sphingosine-1-Phosphate Phosphohydrolase Regulates Endoplasmic Reticulum-to-Golgi Trafficking of Ceramide. Mol. Cell. Biol., July 1, 2006; 26(13): 5055 - 5069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Z. Xu, K. Muraki, F. Zeng, J. Li, P. Sukumar, S. Shah, A. M. Dedman, P. K. Flemming, D. McHugh, J. Naylor, et al. A Sphingosine-1-Phosphate-Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility Circ. Res., June 9, 2006; 98(11): 1381 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brizuela, M. Rabano, A. Pena, P. Gangoiti, J. M. Macarulla, M. Trueba, and A. Gomez-Munoz Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion J. Lipid Res., June 1, 2006; 47(6): 1238 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fukunaga, M. Arita, M. Takahashi, A. J. Morris, M. Pfeffer, and B. D. Levy Identification and Functional Characterization of a Presqualene Diphosphate Phosphatase J. Biol. Chem., April 7, 2006; 281(14): 9490 - 9497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schubert Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? Cardiovasc Res, April 1, 2006; 70(1): 9 - 11. [Full Text] [PDF]
|
|
|
|
|
|
R. Ochi, Y. Momose, K. Oyama, and W. R. Giles Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents Cardiovasc Res, April 1, 2006; 70(1): 88 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kobayashi, T. Nishi, T. Hirata, A. Kihara, T. Sano, Y. Igarashi, and A. Yamaguchi Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner J. Lipid Res., March 1, 2006; 47(3): 614 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Olivera, N. Urtz, K. Mizugishi, Y. Yamashita, A. M. Gilfillan, Y. Furumoto, H. Gu, R. L. Proia, T. Baumruker, and J. Rivera IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses J. Biol. Chem., February 3, 2006; 281(5): 2515 - 2525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Maceyka, H. Sankala, N. C. Hait, H. Le Stunff, H. Liu, R. Toman, C. Collier, M. Zhang, L. S. Satin, A. H. Merrill Jr., et al. SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism J. Biol. Chem., November 4, 2005; 280(44): 37118 - 37129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, X.-P. Xing, A. Holmes, C. Wadham, J. R. Gamble, M. A. Vadas, and P. Xia Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells Circ. Res., October 28, 2005; 97(9): 891 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Schwab, J. P. Pereira, M. Matloubian, Y. Xu, Y. Huang, and J. G. Cyster Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients Science, September 9, 2005; 309(5741): 1735 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Jolly, M. Bektas, K. R. Watterson, H. Sankala, S. G. Payne, S. Milstien, and S. Spiegel Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors Blood, June 15, 2005; 105(12): 4736 - 4742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Damirin, H. Tomura, M. Komachi, M. Tobo, K. Sato, C. Mogi, H. Nochi, K. Tamoto, and F. Okajima Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells Mol. Pharmacol., April 1, 2005; 67(4): 1177 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sanchez, S. Thangada, M.-T. Wu, C. D. Kontos, D. Wu, H. Wu, and T. Hla PTEN as an effector in the signaling of antimigratory G protein-coupled receptor PNAS, March 22, 2005; 102(12): 4312 - 4317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Olivera and J. Rivera Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell J. Immunol., February 1, 2005; 174(3): 1153 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamanaka, D. Shegogue, H. Pei, S. Bu, A. Bielawska, J. Bielawski, B. Pettus, Y. A. Hannun, L. Obeid, and M. Trojanowska Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-{beta} and Mediates TIMP-1 Up-regulation J. Biol. Chem., December 24, 2004; 279(52): 53994 - 54001. [Abstract] [Full Text] [PDF]
|
|