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(Circulation Research. 2004;94:146.)
© 2004 American Heart Association, Inc.

Reviews

Covalent and Noncovalent Modification of Thin Filament Action

The Essential Role of Troponin in Cardiac Muscle Regulation

Joseph M. Metzger, Margaret V. Westfall

From the Departments of Molecular and Integrative Physiology (J.M.M.) and Surgery (M.V.W.), University of Michigan, Ann Arbor, Mich.

Correspondence to Joseph M. Metzger, Dept of Physiology, 7730 Medical Science II, University of Michigan, Ann Arbor, MI 48109. E-mail metzgerj{at}umich.edu

This Review is part of a thematic series on Regulatory Signaling by Thin Filament Modulation, which includes the following articles:

Modulation of Thin Filament Activation by Breakdown or Isoform Switching of Thin Filament Proteins:

Physiological and Pathological Implications

Covalent and Noncovalent Modification of Thin Filament Action: The Essential Role of Troponin in Cardiac Muscle Regulation

Modulation of Thin Filament Activation by Crossbridges

At the Crossroads of Myocardial Signaling: The Role of Z-Discs in Intracellular Signaling and Cardiac

Function
R. John Solaro Guest Editor

Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.

Key Words: calcium • phosphorylation • myocardium • contractility

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