Circulation Research. 2003;92:827-839
doi: 10.1161/01.RES.0000070112.80711.3D
doi: 10.1161/01.RES.0000070112.80711.3D
© 2003 American Heart Association, Inc.
Review |
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
Structure, Function, and Biochemistry
From the Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK.
Correspondence to Dr Hideaki Nagase, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK. E-mail h.nagase{at}imperial.ac.uk
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
Key Words: extracellular matrix • protease • protease inhibitors
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V. S. Golubkov, A. V. Chekanov, S. A. Shiryaev, A. E. Aleshin, B. I. Ratnikov, K. Gawlik, I. Radichev, K. Motamedchaboki, J. W. Smith, and A. Y. Strongin Proteolysis of the Membrane Type-1 Matrix Metalloproteinase Prodomain: IMPLICATIONS FOR A TWO-STEP PROTEOLYTIC PROCESSING AND ACTIVATION J. Biol. Chem., December 14, 2007; 282(50): 36283 - 36291. [Abstract] [Full Text] [PDF]
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Y. Wang, H. Rosen, D. K. Madtes, B. Shao, T. R. Martin, J. W. Heinecke, and X. Fu Myeloperoxidase Inactivates TIMP-1 by Oxidizing Its N-terminal Cysteine Residue: AN OXIDATIVE MECHANISM FOR REGULATING PROTEOLYSIS DURING INFLAMMATION J. Biol. Chem., November 2, 2007; 282(44): 31826 - 31834. [Abstract] [Full Text] [PDF]
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K. Sachidanandam, V. Portik-Dobos, A. K. Harris, J. R. Hutchinson, E. Muller, M. H. Johnson, and A. Ergul Evidence for Vasculoprotective Effects of ETB Receptors in Resistance Artery Remodeling in Diabetes Diabetes, November 1, 2007; 56(11): 2753 - 2758. [Abstract] [Full Text] [PDF]
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J. V. Cockle, N. Gopichandran, J. J. Walker, M. I. Levene, and N. M. Orsi Matrix Metalloproteinases and Their Tissue Inhibitors in Preterm Perinatal Complications Reproductive Sciences, October 1, 2007; 14(7): 629 - 645. [Abstract] [PDF]
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 M C Pustovrh, A Jawerbaum, V White, E Capobianco, R Higa, N Martinez, J J Lopez-Costa, and E Gonzalez The role of nitric oxide on matrix metalloproteinase 2 (MMP2) and MMP9 in placenta and fetus from diabetic rats Reproduction, October 1, 2007; 134(4): 605 - 613. [Abstract] [Full Text] [PDF]
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 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
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J. Harslund, O. L. Nielsen, N. Brunner, and H. Offenberg Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1630 - R1639. [Abstract] [Full Text] [PDF]
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S. Munesue, Y. Yoshitomi, Y. Kusano, Y. Koyama, A. Nishiyama, H. Nakanishi, K. Miyazaki, T. Ishimaru, S. Miyaura, M. Okayama, et al. A Novel Function of Syndecan-2, Suppression of Matrix Metalloproteinase-2 Activation, Which Causes Suppression of Metastasis J. Biol. Chem., September 21, 2007; 282(38): 28164 - 28174. [Abstract] [Full Text] [PDF]
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B. Du, H. Leung, K.M. F. Khan, C. G. Miller, K. Subbaramaiah, D. J. Falcone, and A. J. Dannenberg Tobacco Smoke Induces Urokinase-Type Plasminogen Activator and Cell Invasiveness: Evidence for an Epidermal Growth Factor Receptor Dependent Mechanism Cancer Res., September 15, 2007; 67(18): 8966 - 8972. [Abstract] [Full Text] [PDF]
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L. M. Hodgkinson, G. Duncan, L. Wang, C. J. Pennington, D. R. Edwards, and I. M. Wormstone MMP and TIMP Expression in Quiescent, Dividing, and Differentiating Human Lens Cells Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4192 - 4199. [Abstract] [Full Text] [PDF]
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 C. Muratori, A. Sistigu, E. Ruggiero, M. Falchi, I. Bacigalupo, C. Palladino, E. Toschi, and M. Federico Macrophages Transmit Human Immunodeficiency Virus Type 1 Products to CD4-Negative Cells: Involvement of Matrix Metalloproteinase 9 J. Virol., September 1, 2007; 81(17): 9078 - 9087. [Abstract] [Full Text] [PDF]
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 K. M. Thrailkill, R. C. Bunn, C. S. Moreau, G. E. Cockrell, P. M. Simpson, H. N. Coleman, J. P. Frindik, S. F. Kemp, and J. L. Fowlkes Matrix Metalloproteinase-2 Dysregulation in Type 1 Diabetes Diabetes Care, September 1, 2007; 30(9): 2321 - 2326. [Abstract] [Full Text] [PDF]
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 B. Gogly, A. Naveau, B. Fournier, N. Reinald, E. Durand, C. Brasselet, B. Coulomb, and A. Lafont Preservation of Rabbit Aorta Elastin From Degradation by Gingival Fibroblasts in an Ex Vivo Model Arterioscler Thromb Vasc Biol, September 1, 2007; 27(9): 1984 - 1990. [Abstract] [Full Text] [PDF]
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S. Thalmann and C. A. Meier Local adipose tissue depots as cardiovascular risk factors Cardiovasc Res, September 1, 2007; 75(4): 690 - 701. [Abstract] [Full Text] [PDF]
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K. M. Heinemeier, J. L. Olesen, F. Haddad, H. Langberg, M. Kjaer, K. M. Baldwin, and P. Schjerling Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types J. Physiol., August 1, 2007; 582(3): 1303 - 1316. [Abstract] [Full Text] [PDF]
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L.-W. Qian, J. Xie, F. Ye, and S.-J. Gao Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Invasion of Primary Human Umbilical Vein Endothelial Cells by Inducing Matrix Metalloproteinases J. Virol., July 1, 2007; 81(13): 7001 - 7010. [Abstract] [Full Text] [PDF]
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R. K. Andrews, D. Karunakaran, E. E. Gardiner, and M. C. Berndt Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity Arterioscler Thromb Vasc Biol, July 1, 2007; 27(7): 1511 - 1520. [Abstract] [Full Text] [PDF]
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M. H. Pillinger, N. Marjanovic, S.-Y. Kim, Y.-C. Lee, J. U. Scher, J. Roper, A. M. Abeles, P. I. Izmirly, M. Axelrod, M. Y. Pillinger, et al. Helicobacter pylori Stimulates Gastric Epithelial Cell MMP-1 Secretion via CagA-dependent and -independent ERK Activation J. Biol. Chem., June 29, 2007; 282(26): 18722 - 18731. [Abstract] [Full Text] [PDF]
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 S.-J. Chang, T.-Y. Wang, Y.-H. Lee, and C.-J. Tai Extracellular ATP activates nuclear translocation of ERK1/2 leading to the induction of matrix metalloproteinases expression in human endometrial stromal cells J. Endocrinol., June 1, 2007; 193(3): 393 - 404. [Abstract] [Full Text] [PDF]
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H. Bedair, T. T. Liu, J. L. Kaar, S. Badlani, A. J. Russell, Y. Li, and J. Huard Matrix metalloproteinase-1 therapy improves muscle healing J Appl Physiol, June 1, 2007; 102(6): 2338 - 2345. [Abstract] [Full Text] [PDF]
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J. Maleszewski, J. Lu, K. Fox-Talbot, and M. K. Halushka Robust Immunohistochemical Staining of Several Classes of Proteins in Tissues Subjected to Autolysis J. Histochem. Cytochem., June 1, 2007; 55(6): 597 - 606. [Abstract] [Full Text] [PDF]
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B. Marom, M. A. Rahat, N. Lahat, L. Weiss-Cerem, A. Kinarty, and H. Bitterman Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9 J. Leukoc. Biol., June 1, 2007; 81(6): 1466 - 1476. [Abstract] [Full Text] [PDF]
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S. Simsa, O. Genina, and E. M. Ornan Matrix metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process J Anim Sci, June 1, 2007; 85(6): 1393 - 1401. [Abstract] [Full Text] [PDF]
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S. Simsa, A. Hasdai, H. Dan, and E. M. Ornan Differential regulation of MMPs and matrix assembly in chicken and turkey growth-plate chondrocytes Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2216 - R2224. [Abstract] [Full Text] [PDF]
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