Circulation Research. 2003;92:827-839
doi: 10.1161/01.RES.0000070112.80711.3D
doi: 10.1161/01.RES.0000070112.80711.3D
© 2003 American Heart Association, Inc.
Review |
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
Structure, Function, and Biochemistry
From the Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK.
Correspondence to Dr Hideaki Nagase, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK. E-mail h.nagase{at}imperial.ac.uk
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
Key Words: extracellular matrix • protease • protease inhibitors
This article has been cited by other articles:
 |
|
 |
|
  H. Jarvelainen, A. Sainio, M. Koulu, T. N. Wight, and R. Penttinen Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy Pharmacol. Rev., June 1, 2009; 61(2): 198 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Moritz, M. Q. Mazzuca, A. L. Siebel, A. Mibus, D. Arena, M. Tare, J. A. Owens, and M. E. Wlodek Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats J. Physiol., June 1, 2009; 587(11): 2635 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hamada, S. Duarte, S. Tsuchihashi, R. W. Busuttil, and A. J. Coito Inducible Nitric Oxide Synthase Deficiency Impairs Matrix Metalloproteinase-9 Activity and Disrupts Leukocyte Migration in Hepatic Ischemia/Reperfusion Injury Am. J. Pathol., June 1, 2009; 174(6): 2265 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bertini, M. Fragai, C. Luchinat, M. Melikian, E. Mylonas, N. Sarti, and D. I. Svergun Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1) J. Biol. Chem., May 8, 2009; 284(19): 12821 - 12828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, M. J. Wilson, J. W. Slaton, A. A. Sinha, S. L. Ewing, and D. Pei Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) J Androl, May 1, 2009; 30(3): 259 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. MacLauchlan, E. A. Skokos, N. Meznarich, D. H. Zhu, S. Raoof, J. M. Shipley, R. M. Senior, P. Bornstein, and T. R. Kyriakides Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9 J. Leukoc. Biol., April 1, 2009; 85(4): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Langlois, F. Chouinard, N. Flamand, C. Ferland, M. Rola-Pleszczynski, and M. Laviolette Crucial implication of protein kinase C (PKC)-{delta}, PKC-{zeta}, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils J. Leukoc. Biol., April 1, 2009; 85(4): 656 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hammoud, D. E. Burger, X. Lu, and Q. Feng Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling Am J Physiol Cell Physiol, April 1, 2009; 296(4): C735 - C745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ponnuchamy and R. A. Khalil Cellular mediators of renal vascular dysfunction in hypertension Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1001 - R1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Macgregor, C. G. Eberhart, M. Fraig, J. Lu, and M. K. Halushka Tissue Inhibitor of Matrix Metalloproteinase-3 Levels in the Extracellular Matrix of Lung, Kidney, and Eye Increase With Age J. Histochem. Cytochem., March 1, 2009; 57(3): 207 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Sullivan, C. C. Carroll, B. Jemiolo, S. W. Trappe, S. P. Magnusson, S. Dossing, M. Kjaer, and T. A. Trappe Effect of acute resistance exercise and sex on human patellar tendon structural and regulatory mRNA expression J Appl Physiol, February 1, 2009; 106(2): 468 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zong, L. A. Meyn, and P. A. Moalli The Amount and Activity of Active Matrix Metalloproteinase 13 Is Suppressed by Estradiol and Progesterone in Human Pelvic Floor Fibroblasts Biol Reprod, February 1, 2009; 80(2): 367 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kumar, A. Ray, and B. K. Ray Transcriptional Synergy Mediated by SAF-1 and AP-1: CRITICAL ROLE OF N-TERMINAL POLYALANINE AND TWO ZINC FINGER DOMAINS OF SAF-1 J. Biol. Chem., January 16, 2009; 284(3): 1853 - 1862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Lehmann, R. Debret, A. Romeas, H. Magloire, M. Degrange, F. Bleicher, P. Sommer, and D. Seux Self-etching Increases Matrix Metalloproteinase Expression in the Dentin-Pulp Complex Journal of Dental Research, January 1, 2009; 88(1): 77 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sheen, C. M. O'Kane, K. Chaudhary, M. Tovar, C. Santillan, J. Sosa, L. Caviedes, R. H. Gilman, G. Stamp, and J. S. Friedland High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation Eur. Respir. J., January 1, 2009; 33(1): 134 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sachidanandam, J. R. Hutchinson, M. M. Elgebaly, E. M. Mezzetti, M.-H. Wang, and A. Ergul Differential Effects of Diet-Induced Dyslipidemia and Hyperglycemia on Mesenteric Resistance Artery Structure and Function in Type 2 Diabetes J. Pharmacol. Exp. Ther., January 1, 2009; 328(1): 123 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. GENTNER, A. WEIN, R. S. CRONER, I. ZEITTRAEGER, R. M. WIRTZ, F. ROEDEL, A. DIMMLER, L. DORLAQUE, W. HOHENBERGER, E. G. HAHN, et al. Differences in the Gene Expression Profile of Matrix Metalloproteinases (MMPs) and their Inhibitors (TIMPs) in Primary Colorectal Tumors and their Synchronous Liver Metastases Anticancer Res, January 1, 2009; 29(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Plaisier, I. Dennert, E. Rost, P. Koolwijk, V.W.M. van Hinsbergh, and F.M. Helmerhorst Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions Hum. Reprod., January 1, 2009; 24(1): 185 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, A. Sohail, Q. Sun, Q. Shi, S. Kim, S. Mobashery, and R. Fridman Identification and Role of the Homodimerization Interface of the Glycosylphosphatidylinositol-anchored Membrane Type 6 Matrix Metalloproteinase (MMP25) J. Biol. Chem., December 12, 2008; 283(50): 35023 - 35032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fujimoto, D. Hartung, S. Ohshima, D. S. Edwards, J. Zhou, P. Yalamanchili, M. Azure, A. Fujimoto, S. Isobe, Y. Matsumoto, et al. Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions: Resolution With Dietary Modification and Statin Therapy J. Am. Coll. Cardiol., December 2, 2008; 52(23): 1847 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nan, T. Niu, D. J. Hunter, and J. Han Missense Polymorphisms in Matrix Metalloproteinase Genes and Skin Cancer Risk Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3551 - 3557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Gibbs, K. Roelants, and M. K. O'Bryan The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins--Roles in Reproduction, Cancer, and Immune Defense Endocr. Rev., December 1, 2008; 29(7): 865 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-S. Dabert-Gay, B. Czarny, L. Devel, F. Beau, E. Lajeunesse, S. Bregant, R. Thai, A. Yiotakis, and V. Dive Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe: INSIGHTS INTO ACTIVITY-BASED PROBE DEVELOPMENT AND CONFORMATIONAL VARIABILITY OF MATRIX METALLOPROTEINASES J. Biol. Chem., November 7, 2008; 283(45): 31058 - 31067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, L. Nie, M. Razavian, M. Ahmed, L. W. Dobrucki, A. Asadi, D. S. Edwards, M. Azure, A. J. Sinusas, and M. M. Sadeghi Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling Circulation, November 4, 2008; 118(19): 1953 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Levay, J. D. Peacock, Y. Lu, M. Koch, R. B. Hinton Jr, K. E. Kadler, and J. Lincoln Scleraxis Is Required for Cell Lineage Differentiation and Extracellular Matrix Remodeling During Murine Heart Valve Formation In Vivo Circ. Res., October 24, 2008; 103(9): 948 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mukherjee, J. A. Zavadzkas, S. M. Saunders, J. E. McLean, L. B. Jeffords, C. Beck, R. E. Stroud, A. M. Leone, C. N. Koval, W. T. Rivers, et al. Targeted Myocardial Microinjections of a Biocomposite Material Reduces Infarct Expansion in Pigs Ann. Thorac. Surg., October 1, 2008; 86(4): 1268 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kelly, S. Q. Khan, M. Thompson, G. Cockerill, L. L. Ng, N. Samani, and I. B. Squire Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction Eur. Heart J., September 1, 2008; 29(17): 2116 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wadhwa and S. Kapila TMJ Disorders: Future Innovations in Diagnostics and Therapeutics J Dent Educ., August 1, 2008; 72(8): 930 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goda, H. Inoue, Y. Kaneshita, Y. Nagano, Y. T. Ikeo, J. Iida, and N. Domae Emdogain Stimulates Matrix Degradation by Osteoblasts Journal of Dental Research, August 1, 2008; 87(8): 782 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Lee, N. J. Kang, M.-H. Oak, M. K. Hwang, J. H. Kim, V. B. Schini-Kerth, and H. J. Lee Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities Cardiovasc Res, July 1, 2008; 79(1): 34 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rampon, S. Bouillot, A. Climescu-Haulica, M.-H. Prandini, F. Cand, Y. Vandenbrouck, and P. Huber Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta Physiol Genomics, July 1, 2008; 34(2): 193 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ouyang, S. Lu, X.-Y. Li, J. Xu, J. Seong, B. N. G. Giepmans, J. Y.-J. Shyy, S. J. Weiss, and Y. Wang Visualization of Polarized Membrane Type 1 Matrix Metalloproteinase Activity in Live Cells by Fluorescence Resonance Energy Transfer Imaging J. Biol. Chem., June 20, 2008; 283(25): 17740 - 17748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cai, X. Zhang, Q. Hong, F. Shao, X. Shang, B. Fu, Z. Feng, H. Lin, J. Wang, S. Shi, et al. Tissue inhibitor of metalloproteinase-1 exacerbated renal interstitial fibrosis through enhancing inflammation Nephrol. Dial. Transplant., June 1, 2008; 23(6): 1861 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hasky-Negev, S. Simsa, A. Tong, O. Genina, and E. Monsonego Ornan Expression of matrix metalloproteinases during vascularization and ossification of normal and impaired avian growth plate J Anim Sci, June 1, 2008; 86(6): 1306 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Hoyland, C. Le Maitre, and A. J. Freemont Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc Rheumatology, June 1, 2008; 47(6): 809 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Itoh, N. Ito, H. Nagase, and M. Seiki The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface J. Biol. Chem., May 9, 2008; 283(19): 13053 - 13062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Sauter, A. Rosenberger, L. Beckmann, S. Kropp, K. Mittelstrass, M. Timofeeva, G. Wolke, A. Steinwachs, D. Scheiner, E. Meese, et al. Matrix Metalloproteinase 1 (MMP1) Is Associated with Early-Onset Lung Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1127 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bendrik, J. Robertson, J. Gauldie, and C. Dabrosin Gene Transfer of Matrix Metalloproteinase-9 Induces Tumor Regression of Breast Cancer In vivo Cancer Res., May 1, 2008; 68(9): 3405 - 3412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W.M. van Hinsbergh and P. Koolwijk Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead Cardiovasc Res, May 1, 2008; 78(2): 203 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J D Raffetto and R A Khalil Mechanisms of varicose vein formation: valve dysfunction and wall dilation Phlebology, April 1, 2008; 23(2): 85 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Morikawa, N. Ohara, Q. Xu, K. Nakabayashi, D. A. DeManno, K. Chwalisz, S. Yoshida, and T. Maruo Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer Hum. Reprod., April 1, 2008; 23(4): 944 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Koitabashi, M. Arai, K. Niwano, A. Watanabe, M. Endoh, M. Suguta, T. Yokoyama, H. Tada, T. Toyama, H. Adachi, et al. Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure Eur J Heart Fail, April 1, 2008; 10(4): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gerg, C. Kopitz, S. Schaten, A. Tschukes, C. Kahlert, M. Stangl, C. W. Hann von Weyhern, B. L.D.M. Brucher, D. R. Edwards, K. Brand, et al. Distinct Functionality of Tumor Cell-Derived Gelatinases during Formation of Liver Metastases Mol. Cancer Res., March 1, 2008; 6(3): 341 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Fazel, L. Chen, D. Angoulvant, S.-H. Li, R. D. Weisel, A. Keating, and R.-K. Li Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury FASEB J, March 1, 2008; 22(3): 930 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Xu, N. Ohara, J. Liu, M. Amano, R. Sitruk-Ware, S. Yoshida, and T. Maruo Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells Mol. Hum. Reprod., March 1, 2008; 14(3): 181 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Baldan, A. V. Gomes, P. Ping, and P. A. Edwards Loss of ABCG1 Results in Chronic Pulmonary Inflammation J. Immunol., March 1, 2008; 180(5): 3560 - 3568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Perumal, O. Antipova, and J. P. R. O. Orgel Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis PNAS, February 26, 2008; 105(8): 2824 - 2829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Schneider, G. K. Sukhova, M. Aikawa, J. Canner, N. Gerdes, S.-M. T. Tang, G.-P. Shi, S. S. Apte, and P. Libby Matrix Metalloproteinase-14 Deficiency in Bone Marrow-Derived Cells Promotes Collagen Accumulation in Mouse Atherosclerotic Plaques Circulation, February 19, 2008; 117(7): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Y. Mahller, S. S. Vaikunth, M. C. Ripberger, W. H. Baird, Y. Saeki, J. A. Cancelas, T. M. Crombleholme, and T. P. Cripe Tissue Inhibitor of Metalloproteinase-3 via Oncolytic Herpesvirus Inhibits Tumor Growth and Vascular Progenitors Cancer Res., February 15, 2008; 68(4): 1170 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Kim, J.-J. Li, K. S. Kim, S.-J. Kwak, D.-S. Jung, D.-R. Ryu, T.-H. Yoo, H. Y. Choi, S. H. Han, H. J. Kim, et al. High glucose decreases collagenase expression and increases TIMP expression in cultured human peritoneal mesothelial cells Nephrol. Dial. Transplant., February 1, 2008; 23(2): 534 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Boden, W. Song, L. Pashko, and K. Kresge In Vivo Effects of Insulin and Free Fatty Acids on Matrix Metalloproteinases in Rat Aorta Diabetes, February 1, 2008; 57(2): 476 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D'Alessio, G. Ferrari, K. Cinnante, W. Scheerer, A. C. Galloway, D. F. Roses, D. V. Rozanov, A. G. Remacle, E.-S. Oh, S. A. Shiryaev, et al. Tissue Inhibitor of Metalloproteinases-2 Binding to Membrane-type 1 Matrix Metalloproteinase Induces MAPK Activation and Cell Growth by a Non-proteolytic Mechanism J. Biol. Chem., January 4, 2008; 283(1): 87 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Plaisier, P. Koolwijk, F. Willems, F. M. Helmerhorst, and V. W.M. van Hinsbergh Pericellular-acting proteases in human first trimester decidua Mol. Hum. Reprod., January 1, 2008; 14(1): 41 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Golubkov, A. V. Chekanov, S. A. Shiryaev, A. E. Aleshin, B. I. Ratnikov, K. Gawlik, I. Radichev, K. Motamedchaboki, J. W. Smith, and A. Y. Strongin Proteolysis of the Membrane Type-1 Matrix Metalloproteinase Prodomain: IMPLICATIONS FOR A TWO-STEP PROTEOLYTIC PROCESSING AND ACTIVATION J. Biol. Chem., December 14, 2007; 282(50): 36283 - 36291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, H. Rosen, D. K. Madtes, B. Shao, T. R. Martin, J. W. Heinecke, and X. Fu Myeloperoxidase Inactivates TIMP-1 by Oxidizing Its N-terminal Cysteine Residue: AN OXIDATIVE MECHANISM FOR REGULATING PROTEOLYSIS DURING INFLAMMATION J. Biol. Chem., November 2, 2007; 282(44): 31826 - 31834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sachidanandam, V. Portik-Dobos, A. K. Harris, J. R. Hutchinson, E. Muller, M. H. Johnson, and A. Ergul Evidence for Vasculoprotective Effects of ETB Receptors in Resistance Artery Remodeling in Diabetes Diabetes, November 1, 2007; 56(11): 2753 - 2758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Cockle, N. Gopichandran, J. J. Walker, M. I. Levene, and N. M. Orsi Matrix Metalloproteinases and Their Tissue Inhibitors in Preterm Perinatal Complications Reproductive Sciences, October 1, 2007; 14(7): 629 - 645. [Abstract] [PDF]
|
|
|
|
 |
|
 M C Pustovrh, A Jawerbaum, V White, E Capobianco, R Higa, N Martinez, J J Lopez-Costa, and E Gonzalez The role of nitric oxide on matrix metalloproteinase 2 (MMP2) and MMP9 in placenta and fetus from diabetic rats Reproduction, October 1, 2007; 134(4): 605 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Harslund, O. L. Nielsen, N. Brunner, and H. Offenberg Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1630 - R1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Munesue, Y. Yoshitomi, Y. Kusano, Y. Koyama, A. Nishiyama, H. Nakanishi, K. Miyazaki, T. Ishimaru, S. Miyaura, M. Okayama, et al. A Novel Function of Syndecan-2, Suppression of Matrix Metalloproteinase-2 Activation, Which Causes Suppression of Metastasis J. Biol. Chem., September 21, 2007; 282(38): 28164 - 28174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Du, H. Leung, K.M. F. Khan, C. G. Miller, K. Subbaramaiah, D. J. Falcone, and A. J. Dannenberg Tobacco Smoke Induces Urokinase-Type Plasminogen Activator and Cell Invasiveness: Evidence for an Epidermal Growth Factor Receptor Dependent Mechanism Cancer Res., September 15, 2007; 67(18): 8966 - 8972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Hodgkinson, G. Duncan, L. Wang, C. J. Pennington, D. R. Edwards, and I. M. Wormstone MMP and TIMP Expression in Quiescent, Dividing, and Differentiating Human Lens Cells Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4192 - 4199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Muratori, A. Sistigu, E. Ruggiero, M. Falchi, I. Bacigalupo, C. Palladino, E. Toschi, and M. Federico Macrophages Transmit Human Immunodeficiency Virus Type 1 Products to CD4-Negative Cells: Involvement of Matrix Metalloproteinase 9 J. Virol., September 1, 2007; 81(17): 9078 - 9087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Thrailkill, R. C. Bunn, C. S. Moreau, G. E. Cockrell, P. M. Simpson, H. N. Coleman, J. P. Frindik, S. F. Kemp, and J. L. Fowlkes Matrix Metalloproteinase-2 Dysregulation in Type 1 Diabetes Diabetes Care, September 1, 2007; 30(9): 2321 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gogly, A. Naveau, B. Fournier, N. Reinald, E. Durand, C. Brasselet, B. Coulomb, and A. Lafont Preservation of Rabbit Aorta Elastin From Degradation by Gingival Fibroblasts in an Ex Vivo Model Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1984 - 1990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thalmann and C. A. Meier Local adipose tissue depots as cardiovascular risk factors Cardiovasc Res, September 1, 2007; 75(4): 690 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kasper, J. D. Glaeser, S. Geissler, A. Ode, J. Tuischer, G. Matziolis, C. Perka, and G. N. Duda Matrix Metalloprotease Activity Is an Essential Link Between Mechanical Stimulus and Mesenchymal Stem Cell Behavior Stem Cells, August 1, 2007; 25(8): 1985 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Heinemeier, J. L. Olesen, F. Haddad, H. Langberg, M. Kjaer, K. M. Baldwin, and P. Schjerling Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types J. Physiol., August 1, 2007; 582(3): 1303 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-W. Qian, J. Xie, F. Ye, and S.-J. Gao Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Invasion of Primary Human Umbilical Vein Endothelial Cells by Inducing Matrix Metalloproteinases J. Virol., July 1, 2007; 81(13): 7001 - 7010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Andrews, D. Karunakaran, E. E. Gardiner, and M. C. Berndt Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity Arterioscler. Thromb. Vasc. Biol., July 1, 2007; 27(7): 1511 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Pillinger, N. Marjanovic, S.-Y. Kim, Y.-C. Lee, J. U. Scher, J. Roper, A. M. Abeles, P. I. Izmirly, M. Axelrod, M. Y. Pillinger, et al. Helicobacter pylori Stimulates Gastric Epithelial Cell MMP-1 Secretion via CagA-dependent and -independent ERK Activation J. Biol. Chem., June 29, 2007; 282(26): 18722 - 18731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-J. Chang, T.-Y. Wang, Y.-H. Lee, and C.-J. Tai Extracellular ATP activates nuclear translocation of ERK1/2 leading to the induction of matrix metalloproteinases expression in human endometrial stromal cells J. Endocrinol., June 1, 2007; 193(3): 393 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bedair, T. T. Liu, J. L. Kaar, S. Badlani, A. J. Russell, Y. Li, and J. Huard Matrix metalloproteinase-1 therapy improves muscle healing J Appl Physiol, June 1, 2007; 102(6): 2338 - 2345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Maleszewski, J. Lu, K. Fox-Talbot, and M. K. Halushka Robust Immunohistochemical Staining of Several Classes of Proteins in Tissues Subjected to Autolysis J. Histochem. Cytochem., June 1, 2007; 55(6): 597 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Marom, M. A. Rahat, N. Lahat, L. Weiss-Cerem, A. Kinarty, and H. Bitterman Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9 J. Leukoc. Biol., June 1, 2007; 81(6): 1466 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Simsa, O. Genina, and E. M. Ornan Matrix metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process J Anim Sci, June 1, 2007; 85(6): 1393 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Simsa, A. Hasdai, H. Dan, and E. M. Ornan Differential regulation of MMPs and matrix assembly in chicken and turkey growth-plate chondrocytes Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2216 - R2224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mazzoni, F. Mannello, F.R. Tay, G.A.M. Tonti, S. Papa, G. Mazzotti, R. Di Lenarda, D.H. Pashley, and L. Breschi Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin Journal of Dental Research, May 1, 2007; 86(5): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ries, V. Egea, M. Karow, H. Kolb, M. Jochum, and P. Neth MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines Blood, May 1, 2007; 109(9): 4055 - 4063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tellier, A. Negre-Salvayre, B. Bocquet, S. Itohara, Y. A. Hannun, R. Salvayre, and N. Auge Role for Furin in Tumor Necrosis Factor Alpha-Induced Activation of the Matrix Metalloproteinase/Sphingolipid Mitogenic Pathway Mol. Cell. Biol., April 15, 2007; 27(8): 2997 - 3007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ovodenko, A. Rostagno, T. A. Neubert, V. Shetty, S. Thomas, A. Yang, J. Liebmann, J. Ghiso, and R. Ritch Proteomic Analysis of Exfoliation Deposits Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1447 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De Becker, P. Van Hummelen, M. Bakkus, I. Vande Broek, J. De Wever, M. De Waele, and I. Van Riet Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3 Haematologica, April 1, 2007; 92(4): 440 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Piccard, P. E. Van den Steen, and G. Opdenakker Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins J. Leukoc. Biol., April 1, 2007; 81(4): 870 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Huang, W. Mitzner, R. Rabold, B. Schofield, H. Lee, S. Biswal, and C. G. Tankersley Variation in senescent-dependent lung changes in inbred mouse strains J Appl Physiol, April 1, 2007; 102(4): 1632 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Park, A. Kim, J.-H. Oh, and A.-S. Chung Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-{kappa}B activation Carcinogenesis, April 1, 2007; 28(4): 837 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Bergman, J. R. Teerlink, R. Mahimkar, L. Li, B.-Q. Zhu, A. Nguyen, S. Dahi, J. S. Karliner, and D. H. Lovett Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1847 - H1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Westermann, S. Rutschow, S. Jager, A. Linderer, S. Anker, A. Riad, T. Unger, H.-P. Schultheiss, M. Pauschinger, and C. Tschope Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy: The Role of Angiotensin Type 1 Receptor Antagonism Diabetes, March 1, 2007; 56(3): 641 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Catania, G. Chen, and A. R. Parrish Role of matrix metalloproteinases in renal pathophysiologies Am J Physiol Renal Physiol, March 1, 2007; 292(3): F905 - F911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lindsey, J. G. Crowston, A. Tran, C. Morris, and R. N. Weinreb Direct Matrix Metalloproteinase Enhancement of Transscleral Permeability Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 752 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moore, X.-D. Shen, F. Gao, R. W. Busuttil, and A. J. Coito Fibronectin-{alpha}4{beta}1 Integrin Interactions Regulate Metalloproteinase-9 Expression in Steatotic Liver Ischemia and Reperfusion Injury Am. J. Pathol., February 1, 2007; 170(2): 567 - 577. [Abstract] [Full Text] [PDF]
|
|