Circulation Research. 2003;92:1182-1192
doi: 10.1161/01.RES.0000074908.17214.FD
doi: 10.1161/01.RES.0000074908.17214.FD
© 2003 American Heart Association, Inc.
Review |
T-Tubule Function in Mammalian Cardiac Myocytes
From the School of Biomedical Sciences, University of Leeds, Leeds, UK.
Correspondence to Clive Orchard, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK. E-mail c.h.orchard{at}leeds.ac.uk
The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular Ca2+ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous Ca2+ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions. The purpose of this review is to provide an overview of recent studies of t-tubule structure and function in cardiac myocytes.
Key Words: cardiac muscle • t-tubules • excitation-contraction coupling • heart failure
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