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(Circulation Research. 2002;91:888.)
© 2002 American Heart Association, Inc.

Reviews

Dance Band on the Titanic

Biomechanical Signaling in Cardiac Hypertrophy

Mark A. Sussman, Andrew McCulloch, Thomas K. Borg

From the Children’s Hospital and Research Foundation (M.S.), Division of Molecular Cardiovascular Biology, Cincinnati, Ohio; the Department of Bioengineering (A.M.), Institute for Molecular Medicine, La Jolla, Calif; and the Department of Developmental Biology and Anatomy (T.K.B.), University of South Carolina, Columbia, SC.

Correspondence to Thomas K. Borg, Department of Developmental Biology and Anatomy, University of South Carolina, Columbia, SC 29208. E-mail borg{at}med.sc.edu

Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.

Key Words: mechanical signaling • cardiac hypertrophy • extracellular matrix

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