Circulation Research. 2002;90:509-519
doi: 10.1161/01.RES.0000013072.51957.B7
doi: 10.1161/01.RES.0000013072.51957.B7
© 2002 American Heart Association, Inc.
Reviews |
Transcriptional Regulation of Vertebrate Cardiac Morphogenesis
From the Division of Cardiovascular Research and Programme in Developmental Biology, The Hospital for Sick Children; Department of Molecular and Medical Genetics, University of Toronto; and the Heart and Stroke/Richard Lewar Centre of Excellence for Cardiovascular Research at the University of Toronto, Toronto, Canada.
Correspondence to Benoit G. Bruneau, PhD, Cardiovascular Research, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8. E-mail bbruneau{at}sickkids.ca
Abstract
Transcription factors can regulate the expression of other genes in a tissue-specific and quantitative manner and are thus major regulators of embryonic developmental processes. Several transcription factors that regulate cardiac genes specifically have been described, and the recent discovery that dominant inherited transcription factor mutations cause congenital heart defects in humans has brought direct medical relevance to the study of cardiac transcription factors in heart development. Although this field of study is extensive, several major gaps in our knowledge of the transcriptional control of heart development still exist. This review will concentrate on recent developments in the field of cardiac transcription factors and their roles in heart formation.
Key Words: transcription factors • gene expression • heart development • embryo • congenital heart defects
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