Published online before print May 16, 2002, doi: 10.1161/01.RES.0000022166.74073.F8
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2002 American Heart Association, Inc.
Reports |
Tyrosine Kinase Activity of Discoidin Domain Receptor 1 Is Necessary for Smooth Muscle Cell Migration and Matrix Metalloproteinase Expression
From the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Correspondence to Michelle P. Bendeck, Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6217, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8. E-mail michelle.bendeck{at}utoronto.ca
Abstract
Smooth muscle cell (SMC) interactions with collagen mediate cell migration during the pathogenesis of atherosclerosis and restenosis. Discoidin domain receptors (DDRs) have been identified as novel collagen receptors. We used aortic SMCs from wild-type and DDR1-/- mice to evaluate the function of the DDR1 in regulating migration. DDR1-/- SMCs exhibited impaired attachment to and migration toward a type I collagen substrate. Matrix metalloproteinase-2 (MMP-2) and MMP-9 activities were concomitantly reduced in these cells. Transfection of a full-length cDNA for DDR1b rescued these deficits, whereas kinase-dead mutants of DDR1 restored attachment but not migration and MMP production. These results suggest that active DDR1 kinase is a central mediator of SMC migration.
Key Words: matrix metalloproteinases • smooth muscle cell migration • discoidin domain receptors
This article has been cited by other articles:
 |
|
 |
|
  C. Franco, G. Hou, P. J. Ahmad, E. Y.K. Fu, L. Koh, W. F. Vogel, and M. P. Bendeck Discoidin Domain Receptor 1 (Ddr1) Deletion Decreases Atherosclerosis by Accelerating Matrix Accumulation and Reducing Inflammation in Low-Density Lipoprotein Receptor-Deficient Mice Circ. Res., May 23, 2008; 102(10): 1202 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Roarty and R. Serra Wnt5a is required for proper mammary gland development and TGF-{beta}-mediated inhibition of ductal growth Development, November 1, 2007; 134(21): 3929 - 3939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Matsuyama, H. Mitsuyama, M. Ono, Y. Shirahama, I. Higashimoto, M. Osame, and K. Arimura Discoidin domain receptor 1 contributes to eosinophil survival in an NF-{kappa}B-dependent manner in Churg-Strauss syndrome Blood, January 1, 2007; 109(1): 22 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Flamant, S. Placier, A. Rodenas, C. A. Curat, W. F. Vogel, C. Chatziantoniou, and J.-C. Dussaule Discoidin Domain Receptor 1 Null Mice Are Protected against Hypertension-Induced Renal Disease J. Am. Soc. Nephrol., December 1, 2006; 17(12): 3374 - 3381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Avivi-Green, M. Singal, and W. F. Vogel Discoidin Domain Receptor 1-deficient Mice Are Resistant to Bleomycin-induced Lung Fibrosis Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 420 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Adiguzel, G. Hou, D. Mulholland, U. Hopfer, N. Fukai, B. Olsen, and M. Bendeck Migration and Growth Are Attenuated in Vascular Smooth Muscle Cells With Type VIII Collagen-Null Alleles Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 56 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yang, J. H. Kim, H. J. Kim, I.-S. Park, I. Y. Kim, and B.-S. Yang Tyrosine 740 Phosphorylation of Discoidin Domain Receptor 2 by Src Stimulates Intramolecular Autophosphorylation and Shc Signaling Complex Formation J. Biol. Chem., November 25, 2005; 280(47): 39058 - 39066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-G. Shyu, Y.-M. Chao, B.-W. Wang, and P. Kuan Regulation of Discoidin Domain Receptor 2 by Cyclic Mechanical Stretch in Cultured Rat Vascular Smooth Muscle Cells Hypertension, September 1, 2005; 46(3): 614 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kaplan-Albuquerque, Y. E. Bogaert, V. Van Putten, M. C. Weiser-Evans, and R. A. Nemenoff Patterns of Gene Expression Differentially Regulated by Platelet-derived Growth Factor and Hypertrophic Stimuli in Vascular Smooth Muscle Cells: MARKERS FOR PHENOTYPIC MODULATION AND RESPONSE TO INJURY J. Biol. Chem., May 20, 2005; 280(20): 19966 - 19976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Matsuyama, M. Watanabe, Y. Shirahama, K.-i. Oonakahara, I. Higashimoto, T. Yoshimura, M. Osame, and K. Arimura Activation of Discoidin Domain Receptor 1 on CD14-Positive Bronchoalveolar Lavage Fluid Cells Induces Chemokine Production in Idiopathic Pulmonary Fibrosis J. Immunol., May 15, 2005; 174(10): 6490 - 6498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zeggini, A. M. Reginato, A. Prais, BPRG Study Group, W. Thomson, W. McLean, and R. Donn Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis Rheumatology, September 1, 2004; 43(9): 1138 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ferri, N. O. Carragher, and E. W. Raines Role of Discoidin Domain Receptors 1 and 2 in Human Smooth Muscle Cell-Mediated Collagen Remodeling: Potential Implications in Atherosclerosis and Lymphangioleiomyomatosis Am. J. Pathol., May 1, 2004; 164(5): 1575 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Matsuyama, L. Wang, W. L. Farrar, M. Faure, and T. Yoshimura Activation of Discoidin Domain Receptor 1 Isoform b with Collagen Up-Regulates Chemokine Production in Human Macrophages: Role of p38 Mitogen-Activated Protein Kinase and NF-{kappa}B J. Immunol., February 15, 2004; 172(4): 2332 - 2340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Curat and W. F. Vogel Discoidin Domain Receptor 1 Controls Growth and Adhesion of Mesangial Cells J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2648 - 2656. [Abstract] [Full Text] [PDF]
|
|