Circulation Research. 2002;90:1087-1092
Published online before print May 9, 2002, doi: 10.1161/01.RES.0000021114.92282.FA
Published online before print May 9, 2002, doi: 10.1161/01.RES.0000021114.92282.FA
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© 2002 American Heart Association, Inc.
Molecular Medicine |
Estrogen Receptor-
Mediates the Protective Effects of Estrogen Against Vascular Injury
From the Molecular Cardiology Research Institute (G.P., R.H.K., M.A., M.E.M.), New England Medical Center, Boston, Mass; and Institut de Génétique et de Biologie Moléculaire et Cellulaire (A.K., S.D., P.C.), CNRS/INSERM/ULP, Collège de France, Illkirch Cedex, France.
Correspondence to Michael E. Mendelsohn, MD, New England Medical Center, 750 Washington St, #80, Boston, MA 0211. E-mail MMendelsohn{at}lifespan.org
Blood vessel cells express the 2 known estrogen receptors, 
and ß (ER, ERß), which are thought to mediate estrogen inhibition of vascular injury and atherosclerosis, but the relative role of ER and ERß in these events is controversial. Estrogen inhibits the vascular injury response to the same extent in ovariectomized female wild-type mice and in the original single gene knockout mice for ER (ERKOChapel Hill [ERKOCH]) and ERß (ERßKOChapel Hill [ERßKOCH]). In double gene knockout mice generated by crossing these animals (ER,ßKOCH), estrogen no longer inhibits medial thickening after vascular injury, but still inhibits vascular smooth muscle cell proliferation and increases uterine weight. The partial retention of estrogen responsiveness in ER,ßKOCH mice could be due either to the presence of a novel, unidentified estrogen receptor or to functional expression of an estrogen receptor- splice variant in the parental ERKOCH mice. To distinguish between these possibilities, we studied recently generated mice fully null for estrogen receptor (ERKOStrasbourg [ERKOSt]) and examined the effect of estrogen on the response to vascular injury. In the present study, we show that after vascular injury in ovariectomized ERKOSt mice, estrogen has no detectable effect on any measure of vascular injury, including medial area, proteoglycan deposition, or smooth muscle cell proliferation. These data demonstrate that estrogen receptor- mediates the protective effects of estrogen on the response to vascular injury.
Key Words: estrogen • hormones • vascular injury • receptors • animal models
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|
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|
|
|
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|
|
|
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|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
M. R. Meyer, E. Haas, and M. Barton Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling Hypertension, June 1, 2006; 47(6): 1019 - 1026. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
W. Koch, P. Hoppmann, A. Pfeufer, J. C. Mueller, A. Schomig, and A. Kastrati No Replication of Association Between Estrogen Receptor {alpha} Gene Polymorphisms and Susceptibility to Myocardial Infarction in a Large Sample of Patients of European Descent Circulation, October 4, 2005; 112(14): 2138 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Kim and J. R. Bender Rapid, Estrogen Receptor-Mediated Signaling: Why Is the Endothelium So Special? Sci. Signal., June 14, 2005; 2005(288): pe28 - pe28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Mendelsohn and R. H. Karas Molecular and Cellular Basis of Cardiovascular Gender Differences Science, June 10, 2005; 308(5728): 1583 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Guo, M. Razandi, A. Pedram, G. Kassab, and E. R. Levin Estrogen Induces Vascular Wall Dilation: MEDIATION THROUGH KINASE SIGNALING TO NITRIC OXIDE AND ESTROGEN RECEPTORS {alpha} AND {beta} J. Biol. Chem., May 20, 2005; 280(20): 19704 - 19710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Byers, A. Zangl, T. M. Phernetton, G. Lopez, D.-b. Chen, and R. R. Magness Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ER{alpha} and ER{beta} levels J. Physiol., May 15, 2005; 565(1): 85 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J. Pamidimukkala, B. Xue, L. G. Newton, D. B. Lubahn, and M. Hay Estrogen receptor-{alpha} mediates estrogen facilitation of baroreflex heart rate responses in conscious mice Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1063 - H1070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
M. Zaitseva, D. S. Yue, J. A. Katzenellenbogen, P. A. W. Rogers, and C. E. Gargett Estrogen Receptor-{alpha} Agonists Promote Angiogenesis in Human Myometrial Microvascular Endothelial Cells Reproductive Sciences, December 1, 2004; 11(8): 529 - 535. [Abstract] [PDF]
|
|
|
|
|
|
Y. Nakamura, K. Igarashi, T. Suzuki, J. Kanno, T. Inoue, C. Tazawa, M. Saruta, T. Ando, N. Moriyama, T. Furukawa, et al. E4F1, a Novel Estrogen-Responsive Gene in Possible Atheroprotection, Revealed by Microarray Analysis Am. J. Pathol., December 1, 2004; 165(6): 2019 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Polanczyk, R. E. Jones, S. Subramanian, M. Afentoulis, C. Rich, M. Zakroczymski, P. Cooke, A. A. Vandenbark, and H. Offner T Lymphocytes Do Not Directly Mediate the Protective Effect of Estrogen on Experimental Autoimmune Encephalomyelitis Am. J. Pathol., December 1, 2004; 165(6): 2069 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. E. Schuit, H.-H. S. Oei, J. C. M. Witteman, C. H. Geurts van Kessel, J. B. J. van Meurs, R. L. Nijhuis, J. P. T. M. van Leeuwen, F. H. de Jong, M. C. Zillikens, A. Hofman, et al. Estrogen Receptor {alpha} Gene Polymorphisms and Risk of Myocardial Infarction JAMA, June 23, 2004; 291(24): 2969 - 2977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Miller, D. J. Tindall, and P. Y. Liu Of Mice, Men, and Hormones Arterioscler Thromb Vasc Biol, June 1, 2004; 24(6): 995 - 997. [Full Text] [PDF]
|
|
|
|
|
|
F. Barchiesi, E. K. Jackson, B. Imthurn, J. Fingerle, D. G. Gillespie, and R. K. Dubey Differential Regulation of Estrogen Receptor Subtypes {alpha} and {beta} in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2373 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Gross, M. Adamczak, T. Rabe, N. A. Harbi, J. Krtil, A. Koch, P. Hamar, K. Amann, and E. Ritz Beneficial Effects of Estrogens on Indices of Renal Damage in Uninephrectomized SHRsp Rats J. Am. Soc. Nephrol., February 1, 2004; 15(2): 348 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Orshal and R. A. Khalil Gender, sex hormones, and vascular tone Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R233 - R249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
J. Widder, T. Pelzer, C. von Poser-Klein, K. Hu, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, and J. Bauersachs Improvement of Endothelial Dysfunction by Selective Estrogen Receptor-{alpha} Stimulation in Ovariectomized SHR Hypertension, November 1, 2003; 42(5): 991 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Harris, L. M. Albert, Y. Leathurby, M. S. Malamas, R. E. Mewshaw, C. P. Miller, Y. P. Kharode, J. Marzolf, B. S. Komm, R. C. Winneker, et al. Evaluation of an Estrogen Receptor-{beta} Agonist in Animal Models of Human Disease Endocrinology, October 1, 2003; 144(10): 4241 - 4249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
T. Watanabe, M. Akishita, T. Nakaoka, K. Kozaki, Y. Miyahara, H. He, Y. Ohike, T. Ogita, S. Inoue, M. Muramatsu, et al. Estrogen receptor {beta} mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation Cardiovasc Res, September 1, 2003; 59(3): 734 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Frasor, D. H. Barnett, J. M. Danes, R. Hess, A. F. Parlow, and B. S. Katzenellenbogen Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) {alpha} Activity by ER{beta} in the Uterus Endocrinology, July 1, 2003; 144(7): 3159 - 3166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
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E. K. Jackson Commentary on Liu et al: Effect of Estrogen and AT1 Receptor Blocker on Neointima Formation Hypertension, October 1, 2002; 40(4): 448 - 450. [Full Text] [PDF]
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 K. J. Ho and J. K. Liao Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease Mol. Interv., July 1, 2002; 2(4): 219 - 228. [Abstract] [Full Text] [PDF]
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