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(Circulation Research. 2002;90:e1.)
© 2002 American Heart Association, Inc.

UltraRapid Communications

Influence of Helicobacter pylori Infection During Atherogenesis In Vivo in Mice

François Mach, Galina K. Sukhova, Murielle Michetti, Peter Libby, Pierre Michetti

From the Leducq Center for Cardiovascular Research (F.M., G.K.S., P.L.), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, and Gastroenterology Division (M.M., P.M.), Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass.

Correspondence to Peter Libby, MD, Brigham and Women’s Hospital, 221 Longwood Ave, LMRC 307, Boston, MA 02115. E-mail plibby{at}rics.bwh.harvard.edu

Abstract

Inflammatory diseases may have a role in the pathogenesis of atherosclerosis. Several epidemiological and clinical studies have explored the possible association between Helicobacter pylori seropositivity, cardiovascular risk factors, and ischemic heart disease. The contradictory results of these studies have fueled a debate regarding the link between H pylori infection and atherogenesis. This study tested the hypothesis that H pylori infection might influence atherosclerosis in vivo in mice. Male wild-type C57/Bl6 mice and LDL-receptor deficient congenic mice were randomly assigned for infection with H pylori. All animals were fed a high-cholesterol diet (1.25%) for 6 or 12 weeks. At autopsy, we compared aortic atherosclerotic lesion formation and lipid deposition. H pylori infection influenced neither the progression of atherosclerotic lesions nor lipid deposition. Moreover, the cellularity of atherosclerotic lesions (macrophages and T cells) did not differ between mice infected or not infected with H pylori. This in vivo study performed in a mouse model of atherosclerosis revealed no indication that H pylori infection might contribute to the development of atherosclerotic lesion formation. The full text of this article is available at http://www.circresaha.org.

Key Words: Helicobacter pylori • atherosclerosis • inflammation

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