Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1961;9:362-373

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MONROE, R. G.
Right arrow Articles by FRENCH, G. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MONROE, R. G.
Right arrow Articles by FRENCH, G. N.
(Circulation Research. 1961;9:362.)
© 1961 American Heart Association, Inc.

Left Ventricular Pressure -Volume Relationships and Myocardial Oxygen Consumption in the Isolated Heart

R. GRIER MONROE M.D.1 GORDON N. FRENCH M.D.1

1 From the Department of Physiology, Harvard School of Public Health, Boston, Massachusetts

An isolated dog-heart preparation, in which absolute volumes were known, was employed to determine left ventricular pressure-volume relationships and myocardial oxygen consumption. Loading was varied from the extreme of zero pressure change to zero volume change during systole. Maximum peak systolic pressures were developed by isovolumetric, and maximum stroke volumes by isobaric contractions. When the load was varied to allow both pressure and volume to change in systole, the peak systolic pressures and the simultaneously determined ventricular volumes could be plotted as a "peak systolic pressure-volume line." Moderate changes in diastolic volume had little effect on the position of the line, and the mechanical work of the heart appeared to depend on the nature of the load rather than the diastolic volume. Epinephrine and digitalis glycosides did not affect diastolic pressure-volume relationships. Heart rate affected the diastolic pressure-volume curve only at rapid rates, where changes in the rate of relaxation produced apparent differences in compliance. Myocardial oxygen consumption is shown to be correlated with peak systolic pressure or volume, and is not mainly determined by either diastolic volume or stroke work.

Submitted on October 3, 1960




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Baxi, C. J. Barclay, and C. L. Gibbs
Energetics of rat papillary muscle during contractions with sinusoidal length changes
Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1545 - H1554.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
S. E. EPSTEIN, D. R. REDWOOD, R. E. GOLDSTEIN, G. D. BEISER, D. R. ROSING, D. L. GLANCY, R. L. REIS, and E. B. STINSON
Angina Pectoris: Pathophysiology, Evaluation, and Treatment
Ann Intern Med, August 1, 1971; 75(2): 263 - 296.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
R. R. Taylor, H. E. Cingolani, T. P. Graham, and R. L. Clancy
Myocardial Oxygen Consumption, Left Ventricular Fibre Shortening and Wall Tension
Cardiovasc Res, July 1, 1967; 1(3): 219 - 228.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
J. W. Covell, J. Ross Jr., R. Taylor, E. H. Sonnenblick, and E. Braunwald
Effects of Increasing Frequency of Contraction on the Force Velocity Relation of Left Ventricle
Cardiovasc Res, January 1, 1967; 1(1): 2 - 8.
[Abstract] [PDF]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1961 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.