Circulation Research. 2001;89:753-762
doi: 10.1161/hh2101.099268
doi: 10.1161/hh2101.099268
© 2001 American Heart Association, Inc.
Reviews |
Cytochrome P450 and Vascular Homeostasis
From the Institut für Kardiovaskuläre Physiologie, Klinikum der J.W.G.-Universität, Frankfurt am Main, Germany.
Correspondence to Dr Ingrid Fleming, Institut für Kardiovaskuläre Physiologie, Klinikum der J.W.G.-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. E-mail fleming{at}em.uni-frankfurt.de
Abstract
Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize arachidonic acid to substances which affect arterial tone, it has become increasingly clear that CYP enzymes expressed within the cardiovascular system play a crucial role in the modulation of vascular homeostasis. There is strong evidence suggesting that the activation of a CYP epoxygenase in endothelial cells is an essential step in nitric oxide and prostacyclin-independent vasodilatation of several vascular beds, particularly in the heart and kidney. A smooth muscle CYP 
-hydroxylase, on the other hand, generates a vasoconstrictor eicosanoid that is central to the myogenic response. Moreover, CYP epoxygenase and -hydroxylase products, as well as CYP-derived reactive oxygen species, are intracellular signal transduction molecules involved in several signaling cascades affecting numerous cellular processes, including vascular cell proliferation and angiogenesis. This review summarizes the vascular effects of epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, both of which are CYP-derived metabolites of arachidonic acid, endogenously generated within endothelial and vascular smooth muscle cells. Although the link between CYP expression/activity and cardiovascular disease is currently tentative, the evidence being accumulated to suggest that CYP pathways are altered in animal models of hypertension and atherosclerosis can no longer be ignored. The development of selective pharmacological tools is, however, a prerequisite for the analysis of the involvement of specific CYP isoforms in the regulation of vascular homeostasis in human subjects.
Key Words: endothelial dysfunction • endothelium-derived hyperpolarizing factor • epoxyeicosatrienoic acids • free radicals • 20-hydroxyeicosatetraenoic acid
This article has been cited by other articles:
 |
|
 |
|
  L.-N. Zhang, J. Vincelette, Y. Cheng, U. Mehra, D. Chen, S.-K. Anandan, R. Gless, H. K. Webb, and Y.-X. Wang Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1265 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schmidt, C. Hughes, J. A. Chudek, S. R. Goodyear, R. M. Aspden, R. Talbot, T. E. Gundersen, R. Blomhoff, C. Henderson, C. R. Wolf, et al. Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb Mol. Cell. Biol., May 15, 2009; 29(10): 2716 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Nayeem, D. S. Ponnoth, M. A. Boegehold, D. C. Zeldin, J. R. Falck, and S. J. Mustafa High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R567 - R574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tang, E. A. Scheef, S. Wang, C. M. Sorenson, C. B. Marcus, C. R. Jefcoate, and N. Sheibani CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression Blood, January 15, 2009; 113(3): 744 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Nayeem, S. M. Poloyac, J. R. Falck, D. C. Zeldin, C. Ledent, D. S. Ponnoth, H. R. Ansari, and S. J. Mustafa Role of CYP epoxygenases in A2AAR-mediated relaxation using A2AAR-null and wild-type mice Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2068 - H2078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Donato, I. Eskurza, K. L. Jablonski, L. B. Gano, G. L. Pierce, and D. R. Seals Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans J Appl Physiol, October 1, 2008; 105(4): 1359 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fang, J. Gu, F. Xie, M. Behr, W. Yang, E. D. Abel, and X. Ding Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity Drug Metab. Dispos., August 1, 2008; 36(8): 1722 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gueler, S. Rong, M. Mengel, J.-K. Park, J. Kiyan, T. Kirsch, I. Dumler, H. Haller, and N. Shushakova Renal Urokinase-Type Plasminogen Activator (uPA) Receptor but not uPA Deficiency Strongly Attenuates Ischemia Reperfusion Injury and Acute Kidney Allograft Rejection J. Immunol., July 15, 2008; 181(2): 1179 - 1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Awumey, S. K. Hill, D. I. Diz, and R. D. Bukoski Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2363 - H2370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Ward, I-J. Tsai, A. Barden, F. M. van Bockxmeer, I. B. Puddey, J. M. Hodgson, and K. D. Croft A Single Nucleotide Polymorphism in the CYP4F2 but not CYP4A11 Gene Is Associated With Increased 20-HETE Excretion and Blood Pressure Hypertension, May 1, 2008; 51(5): 1393 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dhanasekaran, S. K. Gruenloh, J. N. Buonaccorsi, R. Zhang, G. J. Gross, J. R. Falck, P. K. Patel, E. R. Jacobs, and M. Medhora Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H724 - H735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Khan, I. K. Mohan, V. K. Kutala, D. Kumbala, and P. Kuppusamy Cardioprotection by Sulfaphenazole, a Cytochrome P450 Inhibitor: Mitigation of Ischemia-Reperfusion Injury by Scavenging of Reactive Oxygen Species J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 813 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Moilanen, J. Hakkola, M. H. Vaarala, S. Kauppila, P. Hirvikoski, J. T. Vuoristo, R. J. Edwards, and T. K. Paavonen Characterization of androgen-regulated expression of CYP3A5 in human prostate Carcinogenesis, May 1, 2007; 28(5): 916 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. DeLozier, G. E. Kissling, S. J. Coulter, D. Dai, J. F. Foley, J. A. Bradbury, E. Murphy, C. Steenbergen, D. C. Zeldin, and J. A. Goldstein Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues Drug Metab. Dispos., April 1, 2007; 35(4): 682 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Spector and A. W. Norris Action of epoxyeicosatrienoic acids on cellular function Am J Physiol Cell Physiol, March 1, 2007; 292(3): C996 - C1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, R.H. Henning, E. Lipsic, A. van Buiten, W.H. van Gilst, and H. Buikema Acetylcholine stimulated dilatation and stretch induced myogenic constriction in mesenteric artery of rats with chronic heart failure Eur J Heart Fail, February 1, 2007; 9(2): 144 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xu, N. Li, Y. He, V. Timofeyev, L. Lu, H.-J. Tsai, I.-H. Kim, D. Tuteja, R. K. P. Mateo, A. Singapuri, et al. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors PNAS, December 5, 2006; 103(49): 18733 - 18738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rose, A. Banerjee, and S. K. Ramaiah Calpain Inhibition Attenuates iNOS Production and Midzonal Hepatic Necrosis in a Repeat Dose Model of Endotoxemia in Rats Toxicol Pathol, October 1, 2006; 34(6): 785 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kunieda, T. Minamino, J.-i. Nishi, K. Tateno, T. Oyama, T. Katsuno, H. Miyauchi, M. Orimo, S. Okada, M. Takamura, et al. Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p21-Dependent Pathway Circulation, August 29, 2006; 114(9): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Granville and R. A. Gottlieb Having a heart attack? Avoid the "HETE"! Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H485 - H487. [Full Text] [PDF]
|
|
|
|
 |
|
 S Moncada Adventures in vascular biology: a tale of two mediators Phil Trans R Soc B, May 29, 2006; 361(1469): 735 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pokreisz, I. Fleming, L. Kiss, E. Barbosa-Sicard, B. Fisslthaler, J. R. Falck, B. D. Hammock, I.-H. Kim, Z. Szelid, P. Vermeersch, et al. Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling Hypertension, April 1, 2006; 47(4): 762 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Metea and E. A. Newman Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J. Neurosci., March 15, 2006; 26(11): 2862 - 2870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, P. Zhu, and B. D. Freedman Multiple eicosanoid-activated nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands Am J Physiol Cell Physiol, March 1, 2006; 290(3): C873 - C882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ito, Y. P. R. Jarajapu, D. L. Guberski, M. B. Grant, and H. J. Knot Myogenic Tone and Reactivity of Rat Ophthalmic Artery in Acute Exposure to High Glucose and in a Type II Diabetic Model Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 683 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Campbell, B. B. Holmes, J. R. Falck, J. H. Capdevila, and K. M. Gauthier Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H64 - H71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. R. Michaelis, B. Fisslthaler, E. Barbosa-Sicard, J. R. Falck, I. Fleming, and R. Busse Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis J. Cell Sci., December 1, 2005; 118(23): 5489 - 5498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guo, R. J. Roman, J. R. Falck, P. A. Edwards, and A. G. Scicli Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li, G. Zhang, F.-X. Yi, A.-P. Zou, and P.-L. Li Activation of NAD(P)H oxidase by outward movements of H+ ions in renal medullary thick ascending limb of Henle Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1048 - F1056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vriens, G. Owsianik, B. Fisslthaler, M. Suzuki, A. Janssens, T. Voets, C. Morisseau, B.D. Hammock, I. Fleming, R. Busse, et al. Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium Circ. Res., October 28, 2005; 97(9): 908 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhu, X. Liu, E. F. Labelle, and B. D. Freedman Mechanisms of Hypotonicity-Induced Calcium Signaling and Integrin Activation by Arachidonic Acid-Derived Inflammatory Mediators in B Cells J. Immunol., October 15, 2005; 175(8): 4981 - 4989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Gross, J. R. Falck, E. R. Gross, M. Isbell, J. Moore, and K. Nithipatikom Cytochrome P450 and arachidonic acid metabolites: Role in myocardial ischemia/reperfusion injury revisited Cardiovasc Res, October 1, 2005; 68(1): 18 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Westhoff, S. Scheid, M. Tolle, B. Kaynak, S. Schmidt, W. Zidek, S. Sperling, and M. van der Giet A physiogenomic approach to study the regulation of blood pressure Physiol Genomics, September 21, 2005; 23(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Imig Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases Am J Physiol Renal Physiol, September 1, 2005; 289(3): F496 - F503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, X. Wei, X. Xiao, R. Hui, J. W. Card, M. A. Carey, D. W. Wang, and D. C. Zeldin Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 522 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Parker, T. R. Grover, J. P. Kinsella, J. R. Falck, and S. H. Abman Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L261 - L267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Blanco-Rivero, V. Cachofeiro, V. Lahera, R. Aras-Lopez, I. Marquez-Rodas, M. Salaices, F. E. Xavier, M. Ferrer, and G. Balfagon Participation of Prostacyclin in Endothelial Dysfunction Induced by Aldosterone in Normotensive and Hypertensive Rats Hypertension, July 1, 2005; 46(1): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-G. Jiang, C.-L. Chen, J. W. Card, S. Yang, J.-X. Chen, X.-N. Fu, Y.-G. Ning, X. Xiao, D. C. Zeldin, and D. W. Wang Cytochrome P450 2J2 Promotes the Neoplastic Phenotype of Carcinoma Cells and Is Up-regulated in Human Tumors Cancer Res., June 1, 2005; 65(11): 4707 - 4715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Jung, R. P. Brandes, I.-H. Kim, F. Schweda, R. Schmidt, B. D. Hammock, R. Busse, and I. Fleming Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II-Induced Hypertension Hypertension, April 1, 2005; 45(4): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Ljubimov and M. B. Grant P450 in the Angiogenesis Affair: The Unusual Suspect Am. J. Pathol., February 1, 2005; 166(2): 341 - 344. [Full Text] [PDF]
|
|
|
|
|
|
U. R. Michaelis, J. R. Falck, R. Schmidt, R. Busse, and I. Fleming Cytochrome P4502C9-Derived Epoxyeicosatrienoic Acids Induce the Expression of Cyclooxygenase-2 in Endothelial Cells Arterioscler Thromb Vasc Biol, February 1, 2005; 25(2): 321 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fleming Cytochrome P-450 Under Pressure: More Evidence for a Link Between 20-Hydroxyeicosatetraenoic Acid and Hypertension Circulation, January 4, 2005; 111(1): 5 - 7. [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li and A. M Shah Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1014 - R1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nithipatikom, E. R. Gross, M. P. Endsley, J. M. Moore, M. A. Isbell, J. R. Falck, W. B. Campbell, and G. J. Gross Inhibition of Cytochrome P450{omega}-Hydroxylase: A Novel Endogenous Cardioprotective Pathway Circ. Res., October 15, 2004; 95(8): e65 - e71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhatnagar Beating Ischemia: A New Feat of EETs? Circ. Res., September 3, 2004; 95(5): 443 - 445. [Full Text] [PDF]
|
|
|
|
|
|
N. C. Ward, J. Rivera, J. Hodgson, I. B. Puddey, L. J. Beilin, J. R. Falck, and K. D. Croft Urinary 20-Hydroxyeicosatetraenoic Acid Is Associated With Endothelial Dysfunction in Humans Circulation, July 27, 2004; 110(4): 438 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Lee, C. S. Landon, S. J. Nazian, and J. R. Dietz Cytochrome P-450 metabolites in endothelin-stimulated cardiac hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R888 - R893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Granville, B. Tashakkor, C. Takeuchi, A. B. Gustafsson, C. Huang, M. R. Sayen, P. Wentworth Jr., M. Yeager, and R. A. Gottlieb Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors PNAS, February 3, 2004; 101(5): 1321 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nilius, J. Vriens, J. Prenen, G. Droogmans, and T. Voets TRPV4 calcium entry channel: a paradigm for gating diversity Am J Physiol Cell Physiol, February 1, 2004; 286(2): C195 - C205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fichtlscherer, S. Dimmeler, S. Breuer, R. Busse, A. M. Zeiher, and I. Fleming Inhibition of Cytochrome P450 2C9 Improves Endothelium-Dependent, Nitric Oxide-Mediated Vasodilatation in Patients With Coronary Artery Disease Circulation, January 20, 2004; 109(2): 178 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Thum and J. Borlak Mechanistic Role of Cytochrome P450 Monooxygenases in Oxidized Low-Density Lipoprotein-Induced Vascular Injury: Therapy Through LOX-1 Receptor Antagonism? Circ. Res., January 9, 2004; 94 (1): e1 - e13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Viswanathan, B. D. Hammock, J. W. Newman, P. Meerarani, M. Toborek, and B. Hennig Involvement of CYP 2C9 in Mediating the Proinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells J. Am. Coll. Nutr., December 1, 2003; 22(6): 502 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Bivalacqua, M. F. Usta, H. C. Champion, P. J. Kadowitz, and W. J. G. Hellstrom Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease J Androl, November 1, 2003; 24(6_suppl): S17 - S37. [Full Text] [PDF]
|
|
|
|
|
|
A. Yaghi, J. A. Bradbury, D. C. Zeldin, S. Mehta, J. R. Bend, and D. G. McCormack Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L1099 - L1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fleming Brain in the Brawn: The Neuronal Nitric Oxide Synthase as a Regulator of Myogenic Tone Circ. Res., October 3, 2003; 93(7): 586 - 588. [Full Text] [PDF]
|
|
|
|
|
|
D. M. E. Otto, C. J. Henderson, D. Carrie, M. Davey, T. E. Gundersen, R. Blomhoff, R. H. Adams, C. Tickle, and C. R. Wolf Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis Mol. Cell. Biol., September 1, 2003; 23(17): 6103 - 6116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Potente, B. Fisslthaler, R. Busse, and I. Fleming 11,12-Epoxyeicosatrienoic Acid-induced Inhibition of FOXO Factors Promotes Endothelial Proliferation by Down-Regulating p27Kip1 J. Biol. Chem., August 8, 2003; 278(32): 29619 - 29625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lassegue and R. E. Clempus Vascular NAD(P)H oxidases: specific features, expression, and regulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R277 - R297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Wang, J. Wang, H.-H. Chang, B. A. Zand, M. Jiang, A. Nasjletti, and M. Laniado-Schwartzman Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats Am J Physiol Renal Physiol, August 1, 2003; 285(2): F295 - F302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miyazono, D. Zhu, R. Nemenoff, E. R. Jacobs, and E. P. Carter Increased Epoxyeicosatrienoic Acid Formation in the Rat Kidney during Liver Cirrhosis J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1766 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Horiuchi, H. H. Dietrich, K. Hongo, and R. G. Dacey Jr Comparison of P2 Receptor Subtypes Producing Dilation in Rat Intracerebral Arterioles Stroke, June 1, 2003; 34(6): 1473 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morio, E. P. Carter, M. Oka, and I. F. McMurtry EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1762 - H1770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Allen, M. Iftinca, W. C Cole, and F. Plane Smooth muscle membrane potential modulates endothelium-dependent relaxation of rat basilar artery via myo-endothelial gap junctions J. Physiol., December 15, 2002; 545(3): 975 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Fang, N. L. Weintraub, C. L. Oltman, L. L. Stoll, T. L. Kaduce, S. Harmon, K. C. Dellsperger, C. Morisseau, B. D. Hammock, and A. A. Spector Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2306 - H2314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, K. Terata, Q. Chai, H. Li, L. H. Kleinman, and D. D. Gutterman Peroxynitrite Inhibits Ca2+-Activated K+ Channel Activity in Smooth Muscle of Human Coronary Arterioles Circ. Res., November 29, 2002; 91(11): 1070 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Xu, R. A. Santizo, V. L. Baughman, and D. A. Pelligrino ADP-induced pial arteriolar dilation in ovariectomized rats involves gap junctional communication Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1082 - H1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C Parkington, J. A. M Chow, R. G Evans, H. A Coleman, and M. Tare Role for endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations in vivo J. Physiol., August 1, 2002; 542(3): 929 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fleming To Move or Not To Move?: Cytochrome P450 Products and Cell Migration Circ. Res., May 17, 2002; 90(9): 936 - 938. [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, X. Sui, J. A. Bradbury, D. C. Zeldin, M. S. Conte, and J. K. Liao Inhibition of Vascular Smooth Muscle Cell Migration by Cytochrome P450 Epoxygenase-Derived Eicosanoids Circ. Res., May 17, 2002; 90(9): 1020 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Potente, U. R. Michaelis, B. Fisslthaler, R. Busse, and I. Fleming Cytochrome P450 2C9-induced Endothelial Cell Proliferation Involves Induction of Mitogen-activated Protein (MAP) Kinase Phosphatase-1, Inhibition of the c-Jun N-terminal Kinase, and Up-regulation of Cyclin D1 J. Biol. Chem., May 3, 2002; 277(18): 15671 - 15676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Popp, R. P. Brandes, G. Ott, R. Busse, and I. Fleming Dynamic Modulation of Interendothelial Gap Junctional Communication by 11,12-Epoxyeicosatrienoic Acid Circ. Res., April 19, 2002; 90(7): 800 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Popp, R. P. Brandes, G. Ott, R. Busse, and I. Fleming Dynamic Modulation of Interendothelial Gap Junctional Communication by 11,12-Epoxyeicosatrienoic Acid Circ. Res., April 19, 2002; 90(7): 800 - 806. [Abstract] [Full Text] [PDF]
|
|