Circulation Research. 2001;89:259-264
Published online before print July 19, 2001, doi: 10.1161/hh1501.094269
Published online before print July 19, 2001, doi: 10.1161/hh1501.094269
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© 2001 American Heart Association, Inc.
Integrative Physiology |
Regulation of Matrix Metalloproteinase Activity in Ischemic Tissue by Interleukin-10
Role in Ischemia-Induced Angiogenesis
From Institut National de la Santé et de la Recherche Médicale U541, Hôpital Lariboisière, Institut Federatif de Recherche Circulation-Lariboisière, Université Paris, France.
Correspondence to Bernard I. Levy, U541-INSERM, Hôpital Lariboisière, 41 Blvd de la Chapelle, 75475 Paris cedex 10, France. E-mail levy@ infobiogen.fr
Abstract— We have previously shown that deficiency in the anti-inflammatory cytokine interleukin-10 (IL-10) is responsible for enhanced angiogenesis after hindlimb ischemia. This study examined the putative involvement of matrix metalloproteinase (MMP) activation in this process. Ischemia was produced by artery femoral occlusion in both C57BL6 IL-10+/+ and IL-10-/- mice. Angiographic vessel density and laser Doppler perfusion data at day 28 showed significant improvement in ischemic/nonischemic leg ratio by, respectively, 1.8-fold and 1.4-fold in IL-10-/- mice compared with IL-10+/+ mice. This was associated with an increase in vascular endothelial growth factor (VEGF) protein content in the ischemic hindlimb. Three days after ischemia, gelatin zymography showed a significant increase in both pro- and active forms of MMP-2 and MMP-9 in ischemic hindlimbs of IL-10-/- mice compared with IL-10+/+ mice (P<0.01). This increase in MMP activity in IL-10-/- mice was completely inhibited by treatment with BB-94 (5 mg/kg IP), a specific MMP inhibitor. Furthermore, increases in both vessel density and blood perfusion indexes at day 28 in IL-10-/- mice were abolished after treatment with BB-94 (0.78±0.06 versus 1.17±0.09 and 0.62±0.02 versus 0.88±0.04, for vessel density and blood perfusion ratio, respectively, in IL-10-/- mice treated with BB-94 versus untreated IL-10-/- mice, P<0.05). In contrast, BB-94 treatment did not affect the rise in VEGF protein content. These findings in IL-10-/- mice underscore the critical role of MMP activation, in a context of increased VEGF expression, in promoting ischemia-induced angiogenesis.
Key Words: angiogenesis • ischemia • interleukin-10 • matrix metalloproteinase
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