© 2001 American Heart Association, Inc.
Review |
Functional Consequences of Integrin Gene Mutations in Mice
* From the Department of Experimental Pathology, Lund University, Lund, Sweden.
Correspondence to Daniel Bouvard or Cord Brakebusch, Lund University Hospital, Department of Experimental Pathology, 22185 Lund, Sweden. E-mail Daniel.Bouvard{at}pat.lu.se or Cord.Brakebusch@pat.lu.se
Abstract— Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.
Key Words: integrin • knockout • extracellular matrix
This article has been cited by other articles:
 |
|
 |
|
  R. Kinsey, M. R. Williamson, S. Chaudhry, K. T. Mellody, A. McGovern, S. Takahashi, C. A. Shuttleworth, and C. M. Kielty Fibrillin-1 microfibril deposition is dependent on fibronectin assembly J. Cell Sci., August 15, 2008; 121(16): 2696 - 2704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Sundberg-Smith, L. A. DiMichele, R. L. Sayers, C. P. Mack, and J. M. Taylor The LIM Protein Leupaxin Is Enriched in Smooth Muscle and Functions As an Serum Response Factor Cofactor to Induce Smooth Muscle Cell Gene Transcription Circ. Res., June 20, 2008; 102(12): 1502 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. McCarty, M. Barry, D. Crowley, R. T. Bronson, A. Lacy-Hulbert, and R. O. Hynes Genetic Ablation of {alpha}v Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma Am. J. Pathol., June 1, 2008; 172(6): 1740 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Abraham, N. Kogata, R. Fassler, and R. H. Adams Integrin {beta}1 Subunit Controls Mural Cell Adhesion, Spreading, and Blood Vessel Wall Stability Circ. Res., March 14, 2008; 102(5): 562 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-V. Wang, L.-W. Chang, K. Brixius, S. A. Wickstrom, E. Montanez, I. Thievessen, M. Schwander, U. Muller, W. Bloch, U. Mayer, et al. Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage J. Cell Biol., March 5, 2008; 180(5): 1037 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Karsan Notch and Integrin Affinity: A Sticky Situation Sci. Signal., January 15, 2008; 1(2): pe2 - pe2. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Takahashi, M. Leiss, M. Moser, T. Ohashi, T. Kitao, D. Heckmann, A. Pfeifer, H. Kessler, J. Takagi, H. P. Erickson, et al. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly J. Cell Biol., October 3, 2007; 178(1): 167 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Meighan and J. E. Schwarzbauer Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors Genes & Dev., July 1, 2007; 21(13): 1615 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Humphries, A. Byron, and M. J. Humphries Integrin ligands at a glance. J. Cell Sci., October 1, 2006; 119(Pt 19): 3901 - 3903. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stefanidakis and E. Koivunen Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression Blood, September 1, 2006; 108(5): 1441 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wang, J. Li, K. Lyte, N. K. Yashpal, F. Fellows, and C. G. Goodyer Role for {beta}1 Integrin and Its Associated {alpha}3, {alpha}5, and {alpha}6 Subunits in Development of the Human Fetal Pancreas Diabetes, July 1, 2005; 54(7): 2080 - 2089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Semmrich, A. Smith, C. Feterowski, S. Beer, B. Engelhardt, D. H. Busch, B. Bartsch, M. Laschinger, N. Hogg, K. Pfeffer, et al. Importance of integrin LFA-1 deactivation for the generation of immune responses J. Exp. Med., June 20, 2005; 201(12): 1987 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Raymond, M. Kreft, H. Janssen, J. Calafat, and A. Sonnenberg Keratinocytes display normal proliferation, survival and differentiation in conditional {beta}4-integrin knockout mice J. Cell Sci., March 1, 2005; 118(5): 1045 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bengtsson, A. Aszodi, C. Nicolae, E. B. Hunziker, E. Lundgren-Akerlund, and R. Fassler Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes J. Cell Sci., March 1, 2005; 118(5): 929 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Peng, H. Ueda, H. Zhou, T. Stokol, T.-L. Shen, A. Alcaraz, T. Nagy, J.-D. Vassalli, and J.-L. Guan Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice Cardiovasc Res, December 1, 2004; 64(3): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garciadiego-Cazares, C. Rosales, M. Katoh, and J. Chimal-Monroy Coordination of chondrocyte differentiation and joint formation by {alpha}5{beta}1 integrin in the developing appendicular skeleton Development, October 1, 2004; 131(19): 4735 - 4742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pietri, O. Eder, M. A. Breau, P. Topilko, M. Blanche, C. Brakebusch, R. Fassler, J.-P. Thiery, and S. Dufour Conditional {beta}1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system Development, August 15, 2004; 131(16): 3871 - 3883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Goel, M. Fornaro, L. Moro, N. Teider, J. S. Rhim, M. King, and L. R. Languino Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by {beta}1 integrins J. Cell Biol., August 2, 2004; 166(3): 407 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K.Y. Siu and C. Y. Cheng Extracellular Matrix: Recent Advances on Its Role in Junction Dynamics in the Seminiferous Epithelium During Spermatogenesis Biol Reprod, August 1, 2004; 71(2): 375 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stefanidakis, T. Ruohtula, N. Borregaard, C. G. Gahmberg, and E. Koivunen Intracellular and Cell Surface Localization of a Complex between {alpha}M{beta}2 Integrin and Promatrix Metalloproteinase-9 Progelatinase in Neutrophils J. Immunol., June 1, 2004; 172(11): 7060 - 7068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aszodi, E. B. Hunziker, C. Brakebusch, and R. Fassler {beta}1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis Genes & Dev., October 1, 2003; 17(19): 2465 - 2479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Haas, K. Amann, J. Schittny, B. Blaser, U. Muller, and A. Hartner Glomerular and Renal Vascular Structural Changes in {alpha}8 Integrin-Deficient Mice J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Sundberg, L. M. Galante, H. M. Bill, C. P. Mack, and J. M. Taylor An Endogenous Inhibitor of Focal Adhesion Kinase Blocks Rac1/JNK but Not Ras/ERK-dependent Signaling in Vascular Smooth Muscle Cells J. Biol. Chem., August 8, 2003; 278(32): 29783 - 29791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Chan, E. J. Weeber, S. Kurup, J. D. Sweatt, and R. L. Davis Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory J. Neurosci., August 6, 2003; 23(18): 7107 - 7116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Mostafavi-Pour, J. A. Askari, S. J. Parkinson, P. J. Parker, T. T.C. Ng, and M. J. Humphries Integrin-specific signaling pathways controlling focal adhesion formation and cell migration J. Cell Biol., April 14, 2003; 161(1): 155 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-M. Zhang, J. Kapyla, J. S. Puranen, C. G. Knight, C.-F. Tiger, O. T. Pentikainen, M. S. Johnson, R. W. Farndale, J. Heino, and D. Gullberg alpha 11beta 1 Integrin Recognizes the GFOGER Sequence in Interstitial Collagens J. Biol. Chem., February 21, 2003; 278(9): 7270 - 7277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Sussman, A. McCulloch, and T. K. Borg Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy Circ. Res., November 15, 2002; 91(10): 888 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R L Wilder Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases Ann Rheum Dis, November 1, 2002; 61(90002): ii96 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Ustinov and E. F. Plow Delineation of the Key Amino Acids Involved in Neutrophil Inhibitory Factor Binding to the I-domain Supports a Mosaic Model for the Capacity of Integrin alpha Mbeta 2 to Recognize Multiple Ligands J. Biol. Chem., May 17, 2002; 277(21): 18769 - 18776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Eliceiri Integrin and Growth Factor Receptor Crosstalk Circ. Res., December 7, 2001; 89(12): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
|