© 2001 American Heart Association, Inc.
Review |
Functional Consequences of Integrin Gene Mutations in Mice
* From the Department of Experimental Pathology, Lund University, Lund, Sweden.
Correspondence to Daniel Bouvard or Cord Brakebusch, Lund University Hospital, Department of Experimental Pathology, 22185 Lund, Sweden. E-mail Daniel.Bouvard{at}pat.lu.se or Cord.Brakebusch@pat.lu.se
Abstract— Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.
Key Words: integrin • knockout • extracellular matrix
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