Circulation Research. 2001;88:1112-1119
doi: 10.1161/hh1101.091862
doi: 10.1161/hh1101.091862
© 2001 American Heart Association, Inc.
Review |
Integrins and the Myocardium
From the Departments of Physiology, Medicine, and The Cardiovascular Research Laboratories (R.S.R.), UCLA School of Medicine, Los Angeles, Calif; and Department of Developmental Biology & Anatomy (T.K.B.), School of Medicine, University of South Carolina, Columbia, SC.
Correspondence to Robert S. Ross, University of California–Los Angeles School of Medicine, Department of Physiology, Center for the Health Sciences, Room 53-231, 10833 Le Conte Ave, Los Angeles, CA 90095-1751. E-mail rross{at}mednet.ucla.edu
Abstract—Extracellular matrix provides a structural, chemical, and mechanical substrate that is essential in cardiac development, growth, and responses to pathophysiological signals. Transmembrane receptors termed integrins provide a dynamic interaction of environmental cues and intracellular events. Integrins orchestrate multiple functions in the intact organism including organogenesis, regulation of gene expression, cell proliferation, differentiation, migration, and death. They are expressed in all cellular components of the cardiovascular system, including the vasculature, blood, cardiac myocytes and nonmuscle cardiac cells. The focus of this review will be on the role of integrins in the myocardium. We will provide background on integrin structure and function, discuss how the expression of integrins is critical to the form and function of the developing and postnatal myocardium, and review the known data on integrins as signaling molecules in the heart. Finally, we will offer insights to the future research directions into this important family of extracellular matrix receptors in the myocardium.
Key Words: integrin • myocardium • extracellular matrix
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