Circulation Research. 2001;88:998-1003
doi: 10.1161/hh1001.090571
doi: 10.1161/hh1001.090571
© 2001 American Heart Association, Inc.
Review |
Current Perspective on the Role of Apoptosis in Atherothrombotic Disease
From Institut Fédératif de Recherche "Circulation Paris VII " and INSERM U541, Hôpital Lariboisière, Paris, France.
Abstract—Thrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads to vessel occlusion and acute ischemia. In this current perspective, we present evidence for apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may directly affect blood thrombogenicity through the release of apoptotic cells and microparticles into the bloodstream.
Key Words: apoptosis • thrombosis • atherosclerosis • acute coronary syndromes
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