© 2001 American Heart Association, Inc.
Cellular Biology |
TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca2+ Channels in Native Vascular Smooth Muscle Cells
From the School of Biomedical Sciences, University of Leeds, Leeds, UK.
Correspondence to D.J. Beech, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK. E-mail d.j.beech{at}leeds.ac.uk
Abstract—Mammalian counterparts of the Drosophila trp gene have been suggested to encode store-operated Ca2+ channels. These specialized channels are widely distributed and may have a general function to reload Ca2+ into sarcoplasmic reticulum as well as specific functions, including the control of cell proliferation and muscle contraction. Heterologous expression of mammalian trp genes enhances or generates Ca2+ channel activity, but the crucial question of whether any of the genes encode native subunits of store-operated channels remains unanswered. We have investigated if TrpC1 protein (encoded by trp1 gene) is a store-operated channel in freshly isolated smooth muscle cells of resistance arterioles, arteries, and veins from human, mouse, or rabbit. Messenger RNA encoding TrpC1 was broadly expressed. TrpC1-specific antibody targeted to peptide predicted to contribute to the outer vestibule of TrpC1 channels revealed that TrpC1 is localized to the plasma membrane and has an extracellular domain. Peptide-specific binding of the antibody had a functional effect, selectively blocking store-operated Ca2+ channel activity. The antibody is a powerful new tool for the study of mammalian trp1 gene product. The study shows that TrpC1 is a novel physiological Ca2+ channel subunit in arterial smooth muscle cells.
Key Words: calcium channel • blood vessel • artery • vascular smooth muscle
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Y. Yu, M. Sweeney, S. Zhang, O. Platoshyn, J. Landsberg, A. Rothman, and J. X.-J. Yuan PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression Am J Physiol Cell Physiol, February 1, 2003; 284(2): C316 - C330. [Abstract] [Full Text] [PDF]
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 S. O. Sage, S. L. Brownlow, J. A. Rosado, K. S. Authi, S. Hassock, M. X. Zhu, V. Flockerzi, and C. Trost TRP channels and calcium entry in human platelets Blood, December 1, 2002; 100(12): 4245 - 4246. [Full Text] [PDF]
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J. A. Rosado, S. L. Brownlow, and S. O. Sage Endogenously Expressed Trp1 Is Involved in Store-mediated Ca2+ Entry by Conformational Coupling in Human Platelets J. Biol. Chem., October 25, 2002; 277(44): 42157 - 42163. [Abstract] [Full Text] [PDF]
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A. Dalrymple, D.M. Slater, D. Beech, L. Poston, and R.M. Tribe Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus Mol. Hum. Reprod., October 1, 2002; 8(10): 946 - 951. [Abstract] [Full Text] [PDF]
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D. J Beech SOCs - Store-Operated Channels in Vascular Smooth Muscle? J. Physiol., October 1, 2002; 544(1): 1 - 1. [Full Text] [PDF]
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S. Y Cheranov and J. H Jaggar Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient KCa currents J. Physiol., October 1, 2002; 544(1): 71 - 84. [Abstract] [Full Text] [PDF]
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S. R. Hassock, M. X. Zhu, C. Trost, V. Flockerzi, and K. S. Authi Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel Blood, September 26, 2002; 100(8): 2801 - 2811. [Abstract] [Full Text] [PDF]
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R Flemming, A Cheong, A M Dedman, and D J Beech Discrete store-operated calcium influx into an intracellular compartment in rabbit arteriolar smooth muscle J. Physiol., September 1, 2002; 543(2): 455 - 464. [Abstract] [Full Text] [PDF]
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M. Sweeney, Y. Yu, O. Platoshyn, S. Zhang, S. S. McDaniel, and J. X.-J. Yuan Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L144 - L155. [Abstract] [Full Text] [PDF]
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C.-H. Lee, D. Poburko, K.-H. Kuo, C. Y. Seow, and C. van Breemen Ca2+ oscillations, gradients, and homeostasis in vascular smooth muscle Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1571 - H1583. [Abstract] [Full Text] [PDF]
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 B. Minke and B. Cook TRP Channel Proteins and Signal Transduction Physiol Rev, April 1, 2002; 82(2): 429 - 472. [Abstract] [Full Text] [PDF]
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D. G. Welsh, A. D. Morielli, M. T. Nelson, and J. E. Brayden Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries Circ. Res., February 22, 2002; 90(3): 248 - 250. [Abstract] [Full Text] [PDF]
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K. Muraki and Y. Imaizumi A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells J. Physiol., December 1, 2001; 537(2): 431 - 441. [Abstract] [Full Text] [PDF]
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J. M. Nerbonne, C. G. Nichols, T. L. Schwarz, and D. Escande Genetic Manipulation of Cardiac K+ Channel Function in Mice: What Have We Learned, and Where Do We Go From Here? Circ. Res., November 23, 2001; 89(11): 944 - 956. [Abstract] [Full Text] [PDF]
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 K. M. Sanders Signal Transduction in Smooth Muscle: Invited Review: Mechanisms of calcium handling in smooth muscles J Appl Physiol, September 1, 2001; 91(3): 1438 - 1449. [Abstract] [Full Text] [PDF]
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M. A. Hill, H. Zou, S. J. Potocnik, G. A. Meininger, and M. J. Davis Signal Transduction in Smooth Muscle: Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity J Appl Physiol, August 1, 2001; 91(2): 973 - 983. [Abstract] [Full Text] [PDF]
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J. Qu, A. Barbuti, L. Protas, B. Santoro, I. S. Cohen, and R. B. Robinson HCN2 Overexpression in Newborn and Adult Ventricular Myocytes : Distinct Effects on Gating and Excitability Circ. Res., July 6, 2001; 89 (1): e8 - e14. [Abstract] [Full Text] [PDF]
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W. P. Schilling TRP Proteins : Novel Therapeutic Targets for Regional Blood Pressure Control? Circ. Res., February 16, 2001; 88(3): 256 - 259. [Full Text] [PDF]
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 V. Denis and M. S. Cyert Internal Ca2+ release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue J. Cell Biol., January 7, 2002; 156(1): 29 - 34. [Abstract] [Full Text] [PDF]
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S. Jung, R. Strotmann, G. Schultz, and T. D. Plant TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells Am J Physiol Cell Physiol, February 1, 2002; 282(2): C347 - C359. [Abstract] [Full Text] [PDF]
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I. A. Greenwood and S. A. Prestwich Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells Am J Physiol Cell Physiol, April 1, 2002; 282(4): C744 - C753. [Abstract] [Full Text] [PDF]
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C.-H. Lee, R. Rahimian, T. Szado, J. Sandhu, D. Poburko, T. Behra, L. Chan, and C. van Breemen Sequential opening of IP3-sensitive Ca2+ channels and SOC during alpha -adrenergic activation of rabbit vena cava Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1768 - H1777. [Abstract] [Full Text] [PDF]
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D. G. Welsh, A. D. Morielli, M. T. Nelson, and J. E. Brayden Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries Circ. Res., February 22, 2002; 90(3): 248 - 250. [Abstract] [Full Text] [PDF]
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L. C. Ng and A. M. Gurney Store-Operated Channels Mediate Ca2+ Influx and Contraction in Rat Pulmonary Artery Circ. Res., November 9, 2001; 89(10): 923 - 929. [Abstract] [Full Text] [PDF]
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