© 2000 American Heart Association, Inc.
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Endothelial Cells of Hematopoietic Origin Make a Significant Contribution to Adult Blood Vessel Formation
From the Department of Pathology (J.R.C., W.E.K., E.W.R., R.A.S., D.F.B.-P.), University of Washington, Seattle, Wash; and Division of Clinical Research (P.J.M.), Fred Hutchinson Cancer Research Center, Seattle, Wash. Current affiliations: J.R.C., S.C. Johnson Research Center, Mayo Clinic Scottsdale, Scottsdale, Ariz; W.E.K., Department of Clinical Chemistry and Laboratory Medicine, University of Regensburg Medical School, Regensburg, Germany; and G.S., Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa.
Correspondence to Daniel F. Bowen-Pope, University of Washington, Department of Pathology, Box 357470, Health Sciences Center, Room D525, Seattle, WA 98195-7470. E-mail bp{at}u.washington.edu
Granulation tissue formation is an example of new tissue development in an adult. Its rich vascular network has been thought to derive via angiogenic sprouting and extension of preexisting vessels from the surrounding tissue. The possibility that circulating cells of hematopoietic origin can differentiate into vascular endothelial cells (ECs) in areas of vascular remodeling has recently gained credibility. However, no quantitative data have placed the magnitude of this contribution into a physiological perspective. We have used hematopoietic chimeras to determine that 0.2% to 1.4% of ECs in vessels in control tissues derived from hematopoietic progenitors during the 4 months after irradiation and hematopoietic recovery. By contrast, 8.3% to 11.2% of ECs in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulating hematopoietic progenitors. This recruitment of circulating progenitors to newly forming vessels would be difficult to observe in standard histological studies, but it is large enough to be encouraging for attempts to manipulate this contribution for therapeutic gain.
Key Words: hematopoietic stem cell • angiogenesis • endothelial cell
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A. Solowiej, P. Biswas, D. Graesser, and J. A. Madri Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation because of Decreased Angiogenesis Am. J. Pathol., March 1, 2003; 162(3): 953 - 962. [Abstract] [Full Text] [PDF]
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N. Werner, J. Priller, U. Laufs, M. Endres, M. Bohm, U. Dirnagl, and G. Nickenig Bone Marrow-Derived Progenitor Cells Modulate Vascular Reendothelialization and Neointimal Formation: Effect of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Arterioscler. Thromb. Vasc. Biol., October 1, 2002; 22(10): 1567 - 1572. [Abstract] [Full Text] [PDF]
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 M. S. Segal, A. Bihorac, and M. Koc Circulating endothelial cells: tea leaves for renal disease Am J Physiol Renal Physiol, July 1, 2002; 283(1): F11 - F19. [Abstract] [Full Text] [PDF]
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M. G. Frid, V. A. Kale, and K. R. Stenmark Mature Vascular Endothelium Can Give Rise to Smooth Muscle Cells via Endothelial-Mesenchymal Transdifferentiation: In Vitro Analysis Circ. Res., June 14, 2002; 90(11): 1189 - 1196. [Abstract] [Full Text] [PDF]
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 D. C. Hess, W. D. Hill, A. Martin-Studdard, J. Carroll, J. Brailer, and J. Carothers Bone Marrow as a Source of Endothelial Cells and NeuN-Expressing Cells After Stroke Stroke, May 1, 2002; 33(5): 1362 - 1368. [Abstract] [Full Text] [PDF]
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C. Urbich, E. Dernbach, A. M. Zeiher, and S. Dimmeler Double-Edged Role of Statins in Angiogenesis Signaling Circ. Res., April 5, 2002; 90(6): 737 - 744. [Abstract] [Full Text] [PDF]
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B. S. Buetow, J. R. Crosby, W. E. Kaminski, R. K. Ramachandran, P. Lindahl, P. Martin, C. Betsholtz, R. A. Seifert, E. W. Raines, and D. F. Bowen-Pope Platelet-Derived Growth Factor B-Chain of Hematopoietic Origin Is Not Necessary for Granulation Tissue Formation and Its Absence Enhances Vascularization Am. J. Pathol., November 1, 2001; 159(5): 1869 - 1876. [Abstract] [Full Text] [PDF]
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 A. M. Davidoff, C. Y. C. Ng, P. Brown, M. A. Leary, W. W. Spurbeck, J. Zhou, E. Horwitz, E. F. Vanin, and A. W. Nienhuis Bone Marrow-derived Cells Contribute to Tumor Neovasculature and, When Modified to Express an Angiogenesis Inhibitor, Can Restrict Tumor Growth in Mice Clin. Cancer Res., September 1, 2001; 7(9): 2870 - 2879. [Abstract] [Full Text] [PDF]
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M. Harraz, C. Jiao, H. D. Hanlon, R. S. Hartley, and G. C. Schatteman CD34- Blood-Derived Human Endothelial Cell Progenitors Stem Cells, July 1, 2001; 19(4): 304 - 312. [Abstract] [Full Text] [PDF]
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Editorial Policy Changes at Circulation Research Circ. Res., January 19, 2001; 88(1): 1 - 1. [Full Text] [PDF]
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S. V. Brodsky, T. Yamamoto, T. Tada, B. Kim, J. Chen, F. Kajiya, and M. S. Goligorsky Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1140 - F1149. [Abstract] [Full Text] [PDF]
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H. Iwaguro, J.-i. Yamaguchi, C. Kalka, S. Murasawa, H. Masuda, S.-i. Hayashi, M. Silver, T. Li, J. M. Isner, and T. Asahara Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration Circulation, February 12, 2002; 105(6): 732 - 738. [Abstract] [Full Text] [PDF]
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C. Urbich, E. Dernbach, A. M. Zeiher, and S. Dimmeler Double-Edged Role of Statins in Angiogenesis Signaling Circ. Res., April 5, 2002; 90(6): 737 - 744. [Abstract] [Full Text] [PDF]
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