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(Circulation Research. 2000;87:648.)
© 2000 American Heart Association, Inc.

Integrative Physiology

Microvascular Integrity and the Time Course of Myocardial Sodium Accumulation After Acute Infarction

Carlos E. Rochitte, Raymond J. Kim, Hanns B. Hillenbrand, Enn-ling Chen, João A. C. Lima

From the Cardiology Division, Department of Medicine (C.E.R., J.A.C.L.), and Department of Radiology (H.B.H., J.A.C.L.), Johns Hopkins University, Baltimore, Md, and Division of Cardiology, Department of Medicine (R.J.K., E.-l.C.), Northwestern University Medical School, Chicago, Ill. Carlos E. Rochitte’s present address is Heart Institute (InCor), University of São Paulo Medical School, Brazil.

Correspondence to João A.C. Lima, MD, The Johns Hopkins Hospital, Cardiology Division, Blalock 569, 600 N Wolfe St, Baltimore, MD 21287-6568. E-mail jlima{at}mri.jhu.edu

Abstract—Loss of membrane permeability caused by ischemia leads to cellular sodium accumulation and myocardial edema. This phenomenon has important implications to left ventricular structure and function in the first hours after myocardial infarction. We hypothesized that during this period of time, after prolonged coronary occlusion and complete reflow, the rate of myocardial sodium accumulation is governed by microvascular integrity. We used 3-dimensional ²³Na MRI to monitor myocardial sodium content changes over time in an in vivo closed-chest canine model (n=13) of myocardial infarction and reperfusion. Infarcts with microvascular obstruction (MO) defined by both radioactive microspheres and contrast-enhanced ¹H MRI showed a slower rate of sodium accumulation as well as lower blood flow at 20 minutes and 6 hours after reperfusion. Conversely, the absence of MO was associated with faster rates of sodium accumulation and greater blood flow restoration. In addition, infarct size by ²³Na MRI correlated best with infarct size by triphenyltetrazolium chloride and contrast-enhanced ¹H MRI at 9 hours after reperfusion. We conclude that in reperfused myocardial infarction, sodium accumulation is dependent on microvascular integrity and is slower in regions of MO compared with those with patent microvasculature. Finally, ²³Na MRI can be a useful tool for monitoring in vivo myocardial sodium content in acute myocardial infarction.

Key Words: magnetic resonance imaging • sodium • myocardial infarction • microcirculation • reperfusion

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