© 2000 American Heart Association, Inc.
Cellular Biology |
Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs
From the University Laboratory of Physiology (B.F.A.S.S., A.J.S., K.W.L., D.N.) and Department of Cardiovascular Medicine, John Radcliffe Hospital (S.M.B.), Oxford, UK.
Correspondence to Denis Noble, University Laboratory of Physiology, South Parks Rd, Oxford OX1 3PT, UK. E-mail denis.noble{at}physiol.ox.ac.uk
Abstract—A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P<0.05) smaller IpNa than subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density between subepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion of action potential duration across the ventricular wall.
Key Words: persistent sodium current • guinea pig ventricle • regional differences
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