© 2000 American Heart Association, Inc.
Reviews |
Myocardial KATP Channels in Preconditioning
From the Institute of Molecular Cardiobiology, Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Md.
Correspondence to Brian O’Rourke, Johns Hopkins University, 720 Rutland Ave, 844 Ross Building, Baltimore, MD 21205. E-mail bor{at}jhmi.edu
Abstract—We are on the brink of harnessing the cell’s natural defenses against ischemia and reperfusion injury after years of research into the destructive and protective mechanisms involved. Since the discovery of ischemic preconditioning, the surface receptors and signal transduction pathways underlying this phenomenon have been clarified, but many questions remain about the downstream targets that ultimately protect the cell. ATP-sensitive K+ (KATP) channels are thought to play a role in protection, but their mechanism of action has been unclear. Accumulating evidence now suggests that the location of the KATP channels relevant to cytoprotection may be on the mitochondrial inner membrane instead of on the sarcolemma of the cardiac cell. This review discusses recent findings and unanswered questions about the role of KATP channels in preconditioning and protection.
Key Words: KATP • protection • mitochondria • ischemia • apoptosis
This article has been cited by other articles:
 |
|
 |
|
  D. A. Brown and R. L. Moore Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise J Appl Physiol, November 1, 2007; 103(5): 1894 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Scatena, P. Bottoni, G. Botta, G. E. Martorana, and B. Giardina The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic Am J Physiol Cell Physiol, July 1, 2007; 293(1): C12 - C21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Garg and K. Hu Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H322 - H332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Spear, S. K. Prabu, D. Galati, H. Raza, H. K. Anandatheerthavarada, and N. G. Avadhani beta1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2459 - H2466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Chicco, M. S. Johnson, C. J. Armstrong, J. M. Lynch, R. T. Gardner, G. S. Fasen, C. P. Gillenwater, and R. L. Moore Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2432 - H2437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Tong, L. M. Porter, G. Liu, P. Dhar-Chowdhury, S. Srivastava, D. J. Pountney, H. Yoshida, M. Artman, G. I. Fishman, C. Yu, et al. Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H543 - H551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Johnson, R. L. Moore, and D. A. Brown Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2644 - H2647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takeda, M. Akao, M. Matsumoto-Ida, M. Kato, H. Takenaka, Y. Kihara, T. Kume, A. Akaike, and T. Kita Serofendic Acid, a Novel Substance Extracted From Fetal Calf Serum, Protects Against Oxidative Stress in Neonatal Rat Cardiac Myocytes J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1882 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Di Lisa and P. Bernardi Mitochondria and ischemia-reperfusion injury of the heart: Fixing a hole Cardiovasc Res, May 1, 2006; 70(2): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sato, A. D. T. Costa, T. Saito, T. Ogura, H. Ishida, K. D. Garlid, and H. Nakaya Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial KATP Channels, Blocks Sarcolemmal KATP Channels, and Confers Cardioprotection J. Pharmacol. Exp. Ther., January 1, 2006; 316(1): 182 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brown, A. J. Chicco, K. N. Jew, M. S. Johnson, J. M. Lynch, P. A. Watson, and R. L. Moore Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat J. Physiol., December 15, 2005; 569(3): 913 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Obal, S. Dettwiler, C. Favoccia, H. Scharbatke, B. Preckel, and W. Schlack The Influence of Mitochondrial KATP-Channels in the Cardioprotection of Preconditioning and Postconditioning by Sevoflurane in the Rat In Vivo Anesth. Analg., November 1, 2005; 101(5): 1252 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fung, R. R. Fiscus, A. P. C. Yim, G. D. Angelini, and A. A. Arifi The Potential Use of Type-5 Phosphodiesterase Inhibitors in Coronary Artery Bypass Graft Surgery Chest, October 1, 2005; 128(4): 3065 - 3073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Gozal, J. Raphael, J. Rivo, E. Berenshtein, M. Chevion, and B. Drenger Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical production in the rabbit Br. J. Anaesth., October 1, 2005; 95(4): 442 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Brustovetsky, N. Shalbuyeva, and N. Brustovetsky Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria J. Physiol., October 1, 2005; 568(1): 47 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Canyon and G. P. Dobson Pretreatment with an adenosine A1 receptor agonist and lidocaine: A possible alternative to myocardial ischemic preconditioning J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 371 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, J. X. Zhu, I. Wilson, and J. S. Cameron Cardioprotective effects of KATP channel activation during hypoxia in goldfish Carassius auratus J. Exp. Biol., July 15, 2005; 208(14): 2765 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Korge, H. M. Honda, and J. N. Weiss K+-dependent regulation of matrix volume improves mitochondrial function under conditions mimicking ischemia-reperfusion Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H66 - H77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Ferrier and S. E. Howlett Pretreatment with Pinacidil Promotes Arrhythmias in an Isolated Tissue Model of Cardiac Ischemia and Reperfusion J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 823 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A Brown, J. M Lynch, C. J Armstrong, N. M Caruso, L. B Ehlers, M. S Johnson, and R. L Moore Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat J. Physiol., April 15, 2005; 564(2): 619 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Blunt, Y. Chen, J. D. Potter, and P. A. Hofmann Modest actomyosin energy conservation increases myocardial postischemic function Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1088 - H1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Kristiansen, O. Henning, R. K. Kharbanda, J. E. Nielsen-Kudsk, M. R. Schmidt, A. N. Redington, T. T. Nielsen, and H. E. Botker Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1252 - H1256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Milano, P. Bianciardi, A. F. Corno, E. Raddatz, S. Morel, L. K. von Segesser, and M. Samaja Myocardial Impairment in Chronic Hypoxia Is Abolished by Short Aeration Episodes: Involvement of K+ATP Channels Experimental Biology and Medicine, December 1, 2004; 229(11): 1196 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Wellner-Kienitz, K. Bender, A. Rinne, and L. Pott Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh) J. Physiol., December 1, 2004; 561(2): 459 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Quast, D. Stephan, S. Bieger, and U. Russ The Impact of ATP-Sensitive K+ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium Diabetes, December 1, 2004; 53(suppl_3): S156 - S164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Barthel, D. Ebel, J. Mullenheim, D. Obal, B. Preckel, and W. Schlack Effect of lidocaine on ischaemic preconditioning in isolated rat heart Br. J. Anaesth., November 1, 2004; 93(5): 698 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Xu, J. Wang, R. Kodavatiganti, Y. Zeng, and I. S. Kass Activation of Protein Kinase C Contributes to the Isoflurane-Induced Improvement of Functional and Metabolic Recovery in Isolated Ischemic Rat Hearts Anesth. Analg., October 1, 2004; 99(4): 993 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hobbs, P. Foster, C. Prescott, R. Scotland, and A. Ahluwalia Natriuretic Peptide Receptor-C Regulates Coronary Blood Flow and Prevents Myocardial Ischemia/Reperfusion Injury: Novel Cardioprotective Role for Endothelium-Derived C-Type Natriuretic Peptide Circulation, September 7, 2004; 110(10): 1231 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bhatnagar Beating Ischemia: A New Feat of EETs? Circ. Res., September 3, 2004; 95(5): 443 - 445. [Full Text] [PDF]
|
|
|
|
|
|
S. J. Canyon and G. P. Dobson Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1286 - H1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mayr, B. Metzler, Y.-L. Chung, E. McGregor, U. Mayr, H. Troy, Y. Hu, M. Leitges, O. Pachinger, J. R. Griffiths, et al. Ischemic preconditioning exaggerates cardiac damage in PKC-{delta} null mice Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H946 - H956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Beresewicz, M. Maczewski, and M. Duda Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart Cardiovasc Res, July 1, 2004; 63(1): 118 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T B Lindhardt, N Gadsboll, H Kelbaek, K Saunamaki, J K Madsen, P Clemmensen, B Hesse, and S Haunso Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function Heart, April 1, 2004; 90(4): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kumagai, H. Nakashima, and K. Saku The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model Cardiovasc Res, April 1, 2004; 62(1): 105 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O'Rourke Evidence for Mitochondrial K+ Channels and Their Role in Cardioprotection Circ. Res., March 5, 2004; 94(4): 420 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sato, T. Takizawa, T. Saito, S. Kobayashi, Y. Hara, and H. Nakaya Amiodarone Inhibits Sarcolemmal but Not Mitochondrial KATP Channels in Guinea Pig Ventricular Cells J. Pharmacol. Exp. Ther., December 1, 2003; 307(3): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Cameron, K. E. Hoffmann, C. Zia, H. M. Hemmett, A. Kronsteiner, and C. M. Lee A role for nitric oxide in hypoxia-induced activation of cardiac KATP channels in goldfish (Carassius auratus) J. Exp. Biol., November 15, 2003; 206(22): 4057 - 4065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Jones, Y. Teshima, M. Akao, and E. Marban Simvastatin Attenuates Oxidant-Induced Mitochondrial Dysfunction in Cardiac Myocytes Circ. Res., October 17, 2003; 93(8): 697 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D'Angelo, E. Duplan, N. Boyer, P. Vigne, and C. Frelin Hypoxia Up-regulates Prolyl Hydroxylase Activity: A FEEDBACK MECHANSIM THAT LIMITS HIF-1 RESPONSES DURING REOXYGENATION J. Biol. Chem., October 3, 2003; 278(40): 38183 - 38187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zaugg, E. Lucchinetti, M. Uecker, T. Pasch, and M. C. Schaub Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms Br. J. Anaesth., October 1, 2003; 91(4): 551 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Baines, C.-X. Song, Y.-T. Zheng, G.-W. Wang, J. Zhang, O.-L. Wang, Y. Guo, R. Bolli, E. M. Cardwell, and P. Ping Protein Kinase C{epsilon} Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria Circ. Res., May 2, 2003; 92(8): 873 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Steensrud, D. Nordhaug, O.P. Elvenes, C. Korvald, and D.G. Sorlie Superior myocardial protection with nicorandil cardioplegia Eur. J. Cardiothorac. Surg., May 1, 2003; 23(5): 670 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakae, W.-M. Kwok, Z. J. Bosnjak, and M. T. Jiang Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1865 - H1871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Horiguchi, B. Kis, N. Rajapakse, K. Shimizu, and D. W. Busija Opening of Mitochondrial ATP-Sensitive Potassium Channels Is a Trigger of 3-Nitropropionic Acid-Induced Tolerance to Transient Focal Cerebral Ischemia in Rats Stroke, April 1, 2003; 34(4): 1015 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Riddle Sulfonylureas Differ in Effects on Ischemic Preconditioning--Is it Time to Retire Glyburide? J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 528 - 530. [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. McCully and S. Levitsky The mitochondrial KATP channel and cardioprotection Ann. Thorac. Surg., February 1, 2003; 75(2): S667 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vaage and G. Valen Preconditioning and cardiac surgery Ann. Thorac. Surg., February 1, 2003; 75(2): S709 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Schoen and R. F. Padera Jr. Cardiac Surgical Pathology Card. Surg. Adult, January 1, 2003; 2(2003): 119 - 185. [Full Text]
|
|
|
|
|
|
G. Lebuffe, P. T. Schumacker, Z.-H. Shao, T. Anderson, H. Iwase, and T. L. Vanden Hoek ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H299 - H308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.M. Lawrence, A. Chanalaris, T. Scarabelli, M. Hubank, E. Pasini, P.A. Townsend, L. Comini, R. Ferrari, A. Tinker, A. Stephanou, et al. KATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect Circulation, September 17, 2002; 106(12): 1556 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Zhao and J. Vinten-Johansen Myocardial apoptosis and ischemic preconditioning Cardiovasc Res, August 15, 2002; 55(3): 438 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M Smith, N. Suleman, J. McCarthy, and M. N Sack Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNF{alpha} gene Cardiovasc Res, August 15, 2002; 55(3): 553 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Neckar, O. Szarszoi, L. Koten, F. Papousek, B. Ost'adal, G. J Grover, and F. Kolar Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats Cardiovasc Res, August 15, 2002; 55(3): 567 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Ranki, G. R. Budas, R. M. Crawford, A. M. Davies, and A. Jovanovic 17{beta}-Estradiol regulates expression of KATP channels in heart-derived H9c2 cells J. Am. Coll. Cardiol., July 17, 2002; 40(2): 367 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Smith Jr, D. Faxon, W. Cascio, H. Schaff, T. Gardner, A. Jacobs, S. Nissen, and R. Stouffer Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group VI: Revascularization in Diabetic Patients Circulation, May 7, 2002; 105 (18): e165 - e169. [Full Text] [PDF]
|
|
|
|
|
|
C. P. Baines, J. Zhang, G.-W. Wang, Y.-T. Zheng, J. X. Xiu, E. M. Cardwell, R. Bolli, and P. Ping Mitochondrial PKC{epsilon} and MAPK Form Signaling Modules in the Murine Heart: Enhanced Mitochondrial PKC{epsilon}-MAPK Interactions and Differential MAPK Activation in PKC{epsilon}-Induced Cardioprotection Circ. Res., March 8, 2002; 90(4): 390 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pouzet, J.-B. Lecharny, M. Dehoux, S. Paquin, M. Kitakaze, J. Mantz, and P. Menasche Is there a place for preconditioning during cardiac operations in humans? Ann. Thorac. Surg., March 1, 2002; 73(3): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|