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© 2000 American Heart Association, Inc.
Molecular Medicine |
Altered Patterns of Gene Expression in Response to Myocardial Infarction
From Scios Inc, Sunnyvale Calif.
Correspondence to R. Tyler White, Scios Inc, 820 W Maude Ave, Sunnyvale CA 94086. E-mail white{at}sciosinc.com
Abstract—The use of cDNA microarrays has made it possible to simultaneously analyze gene expression for thousands of genes. Microarray technology was used to evaluate the expression of >4000 genes in a rat model of myocardial infarction. More than 200 genes were identified that showed differential expression in response to myocardial infarction. Gene expression changes were monitored from 2 to 16 weeks after infarction in 2 regions of the heart, the left ventricle free wall and interventricular septum. A novel clustering program was used to identify patterns of expression within this large set of data. Unique patterns were revealed within the transcriptional responses that illuminate changes in biological processes associated with myocardial infarction.
Key Words: myocardial infarction • tissue remodeling • gene expression • DNA microarrays
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