© 2000 American Heart Association, Inc.
Molecular Medicine |
Altered Patterns of Gene Expression in Response to Myocardial Infarction
From Scios Inc, Sunnyvale Calif.
Correspondence to R. Tyler White, Scios Inc, 820 W Maude Ave, Sunnyvale CA 94086. E-mail white{at}sciosinc.com
Abstract—The use of cDNA microarrays has made it possible to simultaneously analyze gene expression for thousands of genes. Microarray technology was used to evaluate the expression of >4000 genes in a rat model of myocardial infarction. More than 200 genes were identified that showed differential expression in response to myocardial infarction. Gene expression changes were monitored from 2 to 16 weeks after infarction in 2 regions of the heart, the left ventricle free wall and interventricular septum. A novel clustering program was used to identify patterns of expression within this large set of data. Unique patterns were revealed within the transcriptional responses that illuminate changes in biological processes associated with myocardial infarction.
Key Words: myocardial infarction • tissue remodeling • gene expression • DNA microarrays
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|
 J. Litvin, X. Chen, S. Keleman, S. Zhu, and M. Autieri Expression and function of periostin-like factor in vascular smooth muscle cells Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1672 - C1680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 C. Ojaimi, K. Qanud, T. H. Hintze, and F. A. Recchia Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs Physiol Genomics, March 14, 2007; 29(1): 76 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 C. K. Sen, S. Khanna, and S. Roy Perceived hyperoxia: Oxygen-induced remodeling of the reoxygenated heart Cardiovasc Res, July 15, 2006; 71(2): 280 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Kuhn, S. Roy, J. Radtke, S. Gupta, and C. K. Sen Laser microdissection and pressure-catapulting technique to study gene expression in the reoxygenated myocardium Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2625 - H2632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
S. Roy, S. Khanna, D. E. Kuhn, C. Rink, W. T. Williams, J. L. Zweier, and C. K. Sen Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix Physiol Genomics, May 16, 2006; 25(3): 364 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Rios, S. V. Koushik, H. Wang, J. Wang, H.-M. Zhou, A. Lindsley, R. Rogers, Z. Chen, M. Maeda, A. Kruzynska-Frejtag, et al. periostin Null Mice Exhibit Dwarfism, Incisor Enamel Defects, and an Early-Onset Periodontal Disease-Like Phenotype Mol. Cell. Biol., December 15, 2005; 25(24): 11131 - 11144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Schwinn and M. Podgoreanu Editorial I: The new age of medical genomics Br. J. Anaesth., August 1, 2005; 95(2): 119 - 121. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J. Rysa, H. Leskinen, M. Ilves, and H. Ruskoaho Distinct Upregulation of Extracellular Matrix Genes in Transition From Hypertrophy to Hypertensive Heart Failure Hypertension, May 1, 2005; 45(5): 927 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Kong, N. Bodyak, P. Yue, Z. Liu, J. Brown, S. Izumo, and P. M. Kang Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats Physiol Genomics, March 21, 2005; 21(1): 34 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Freimann, M. Scheinowitz, D. Yekutieli, M. S. Feinberg, M. Eldar, and G. Kessler-Icekson Prior exercise training improves the outcome of acute myocardial infarction in the rat: Heart structure, function, and gene expression J. Am. Coll. Cardiol., March 15, 2005; 45(6): 931 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner and B. Z. Simkhovich Benefit of an exercise program before myocardial infarction J. Am. Coll. Cardiol., March 15, 2005; 45(6): 939 - 940. [Full Text] [PDF]
|
|
|
|
|
|
F. Schwartz, A. Duka, I. Duka, J. Cui, and H. Gavras Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H1957 - H1966. [Abstract] [Full Text] [PDF]
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
O. Tarnavski, J. R. McMullen, M. Schinke, Q. Nie, S. Kong, and S. Izumo Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies Physiol Genomics, February 13, 2004; 16(3): 349 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
M. Mirotsou, C. M.H. Watanabe, P. G. Schultz, R. E. Pratt, and V. J. Dzau Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach Physiol Genomics, October 17, 2003; 15(2): 115 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Z. Simkhovich, P. Marjoram, C. Poizat, L. Kedes, and R. A. Kloner Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study Cardiovasc Res, August 1, 2003; 59(2): 450 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, S. Oparil, J. A. Feng, P. Li, G. Perry, L. B. Chen, M. Dai, S. W.M. John, and Y.-F. Chen Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide-Null Mouse Hypertension, July 1, 2003; 42(1): 88 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Napoli, L O Lerman, V Sica, A Lerman, G Tajana, and F de Nigris Microarray analysis: a novel research tool for cardiovascular scientists and physicians Heart, June 1, 2003; 89(6): 597 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Winslow and M. S. Boguski Genome Informatics: Current Status and Future Prospects Circ. Res., May 16, 2003; 92(9): 953 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lagreid, T. R. Hvidsten, H. Midelfart, J. Komorowski, and A. K. Sandvik Predicting Gene Ontology Biological Process From Temporal Gene Expression Patterns Genome Res., May 1, 2003; 13(5): 965 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Dos Remedios, D. Chhabra, M. Kekic, I. V. Dedova, M. Tsubakihara, D. A. Berry, and N. J. Nosworthy Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments Physiol Rev, April 1, 2003; 83(2): 433 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. N. Khodarev, J. Yu, E. Labay, T. Darga, C. K. Brown, H. J. Mauceri, R. Yassari, N. Gupta, and R. R. Weichselbaum Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells J. Cell Sci., March 15, 2003; 116(6): 1013 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Diffee, E. A. Seversen, T. D. Stein, and J. A. Johnson Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H830 - H837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J Ashton, K. Holmgren, J. Peart, A. R Lankford, G Paul Matherne, S. Grimmond, and J. P Headrick Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression Cardiovasc Res, March 1, 2003; 57(3): 715 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S Chugh, S. Whitesel, M. Turner, C. T Roberts Jr., and S. R Nagalla Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model Cardiovasc Res, February 1, 2003; 57(2): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steenman, Y.-W. Chen, M. Le Cunff, G. Lamirault, A. Varro, E. Hoffman, and J. J. Leger Transcriptomal analysis of failing and nonfailing human hearts Physiol Genomics, January 15, 2003; 12(2): 97 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Weinberg, M. Mirotsou, J. Gannon, V. J. Dzau, R. T. Lee, and R. E. Pratt Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload Physiol Genomics, January 15, 2003; 12(2): 113 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Depre, M. Hase, V. Gaussin, A. Zajac, L. Wang, L. Hittinger, B. Ghaleh, X. Yu, R. K. Kudej, T. Wagner, et al. H11 Kinase Is a Novel Mediator of Myocardial Hypertrophy In Vivo Circ. Res., November 29, 2002; 91(11): 1007 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Cook and A. Rosenzweig DNA Microarrays: Implications for Cardiovascular Medicine Circ. Res., October 4, 2002; 91(7): 559 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. PALINSKI and C. NAPOLI The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis FASEB J, September 1, 2002; 16(11): 1348 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rouger, M. Le Cunff, M. Steenman, M.-C. Potier, N. Gibelin, C. A. Dechesne, and J. J. Leger Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice Am J Physiol Cell Physiol, September 1, 2002; 283(3): C773 - C784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Hwang, P. D. Allen, G. C. Tseng, C.-W. Lam, L. Fananapazir, V. J. Dzau, and C.-C. Liew Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure Physiol Genomics, July 12, 2002; 10(1): 31 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.A Henriksen and Y Kotelevtsev Application of gene expression profiling to cardiovascular disease Cardiovasc Res, April 1, 2002; 54(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Napoli, F. de Nigris, J. S. Welch, F. B. Calara, R. O. Stuart, C. K. Glass, and W. Palinski Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray Circulation, March 19, 2002; 105(11): 1360 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mavroidis and Y. Capetanaki Extensive Induction of Important Mediators of Fibrosis and Dystrophic Calcification in Desmin-Deficient Cardiomyopathy Am. J. Pathol., March 1, 2002; 160(3): 943 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Iida and I. Nishimura GENE EXPRESSION PROFILING BY DNA MICROARRAY TECHNOLOGY Crit. Rev. Oral. Biol. Med., January 1, 2002; 13(1): 35 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. King and A. A. Sinha Gene Expression Profile Analysis by DNA Microarrays: Promise and Pitfalls JAMA, November 14, 2001; 286(18): 2280 - 2288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Jun, S. H. Liu, E. H. Koo, D. V. Do, W. J. Stark, and J. D. Gottsch Microarray Analysis of Gene Expression in Human Donor Corneas Arch Ophthalmol, November 1, 2001; 119(11): 1629 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. N. Khodarev, J. O. Park, J. Yu, N. Gupta, E. Nodzenski, B. Roizman, and R. R. Weichselbaum Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts PNAS, October 23, 2001; 98(22): 12665 - 12670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Lee Functional Genomics and Cardiovascular Drug Discovery Circulation, September 18, 2001; 104(12): 1441 - 1446. [Full Text] [PDF]
|
|
|
|
|
|
C. Depre, J. E. Tomlinson, R. K. Kudej, V. Gaussin, E. Thompson, S.-J. Kim, D. E. Vatner, J. N. Topper, and S. F. Vatner Gene program for cardiac cell survival induced by transient ischemia in conscious pigs PNAS, July 31, 2001; 98(16): 9336 - 9341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Rao and M. Bond Microarrays : Managing the Data Deluge Circ. Res., June 22, 2001; 88(12): 1226 - 1227. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Schneider and R. J. Schwartz Chips Ahoy : Gene Expression in Failing Hearts Surveyed by High-Density Microarrays Circulation, December 19, 2000; 102(25): 3026 - 3027. [Full Text] [PDF]
|