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(Circulation Research. 2000;86:355.)
© 2000 American Heart Association, Inc.

MiniReview

Interactions Between Ca²⁺ and H⁺ and Functional Consequences in Vascular Smooth Muscle

Clare Austin, Susan Wray

From the Department of Medicine (C.A.), Manchester Royal Infirmary, Manchester, and The Physiological Laboratory (S.W.), The University of Liverpool, Liverpool, UK.

Correspondence to Dr Clare Austin, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK. E-mail caustin{at}fs1.cmht.nwest.nhs.uk

Abstract—Ca²⁺ and H⁺ ions can profoundly alter vascular tone. In many physiological and pathological processes, changes in the concentration of both ions occur. Thus, to understand the processes and mechanisms that modify force, it is necessary to understand what changes occur in these ions and, importantly, how they interact with each other. In this minireview, we highlight the quantitatively important mechanisms involved in the contractile responses of vascular tissues to pH change and discuss the cellular and molecular reasons underlying these responses.

Key Words: Ca²⁺ • H⁺ • pH • vascular smooth muscle

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