© 1999 American Heart Association, Inc.
Review |
Oxidative Stress as a Regulator of Gene Expression in the Vasculature
From AtheroGenics, Inc (C.K., R.M.M.), Alpharetta, and Division of Cardiology (R.M.M.), Department of Medicine, Emory University School of Medicine, Atlanta, Ga.
Correspondence to Russell M. Medford, MD, PhD, AtheroGenics, Inc, 8995 Westside Pkwy, Alpharetta, GA 30004. E-mail rmedford{at}atherogen.com
Abstract—Oxidative stress and the production of intracellular reactive oxygen species (ROS) have been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their byproducts that are capable of causing oxidative damage may be cytotoxic to cells. However, it is now well established that moderate amounts of ROS play a role in signal transduction processes such as cell growth and posttranslational modification of proteins. Oxidants, antioxidants, and other determinants of the intracellular reduction-oxidation (redox) state play an important role in the regulation of gene expression. Recent insights into the etiology and pathogenesis of atherosclerosis suggest that this disease may be viewed as an inflammatory disease linked to an abnormality in oxidation-mediated signals in the vasculature. In this review, we summarize the evidence supporting the notion that oxidative stress and the production of ROS function as physiological regulators of vascular gene expression mediated via specific redox-sensitive signal transduction pathways and transcriptional regulatory networks. Elucidating, at the molecular level, the regulatory processes involved in redox-sensitive vascular gene expression represents a foundation not only for understanding the pathogenesis of atherosclerosis and other inflammatory diseases but also for the development of novel therapeutic treatment strategies.
Key Words: redox • gene expression • atherosclerosis • oxidation • signaling
This article has been cited by other articles:
 |
|
 |
|
  Z. Bagi Mechanisms of coronary microvascular adaptation to obesity Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R556 - R567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I-T. Lee, S.-F. Luo, C.-W. Lee, S.-W. Wang, C.-C. Lin, C.-C. Chang, Y.-L. Chen, L.-Y. Chau, and C.-M. Yang Overexpression of HO-1 Protects against TNF-{alpha}-Mediated Airway Inflammation by Down-Regulation of TNFR1-Dependent Oxidative Stress Am. J. Pathol., August 1, 2009; 175(2): 519 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nambiar, S. Viswanathan, B. Zachariah, N. Hanumanthappa, and Sridhar Gopalakrishna Magadi Oxidative Stress in Prehypertension: Rationale for Antioxidant Clinical Trials Angiology, April 1, 2009; 60(2): 221 - 234. [Abstract] [PDF]
|
|
|
|
 |
|
 L. J. He, M. Liang, F. F. Hou, Z. J. Guo, D. Xie, and X. Zhang Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action J. Endocrinol., March 1, 2009; 200(3): 347 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cottone, G. Mule, M. Guarneri, A. Palermo, M. C. Lorito, R. Riccobene, R. Arsena, F. Vaccaro, A. Vadala, E. Nardi, et al. Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients Nephrol. Dial. Transplant., February 1, 2009; 24(2): 497 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Farrow, S. Lakshminrusimha, W. J. Reda, S. Wedgwood, L. Czech, S. F. Gugino, J. M. Davis, J. A. Russell, and R. H. Steinhorn Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, December 1, 2008; 295(6): L979 - L987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Handa, J. Stephen, and G. Cepinskas Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1712 - H1719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. A. Ali, C. A. Bursill, G. Douglas, E. McNeill, M. Papaspyridonos, A. L. Tatham, J. K. Bendall, A. M. Akhtar, N. J. Alp, D. R. Greaves, et al. CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury-Induced Accelerated Atherosclerosis Circulation, September 30, 2008; 118(14_suppl_1): S71 - S77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Liu, L. Gao, S. K. Roy, K. G. Cornish, and I. H. Zucker Role of Oxidant Stress on AT1 Receptor Expression in Neurons of Rabbits With Heart Failure and in Cultured Neurons Circ. Res., July 18, 2008; 103(2): 186 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mollace, S. Ragusa, I. Sacco, C. Muscoli, F. Sculco, V. Visalli, E. Palma, S. Muscoli, L. Mondello, P. Dugo, et al. The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2008; 13(2): 120 - 129. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Bukowska, L. Schild, G. Keilhoff, D. Hirte, M. Neumann, A. Gardemann, K. H. Neumann, F.-W. Rohl, C. Huth, A. Goette, et al. Mitochondrial Dysfunction and Redox Signaling in Atrial Tachyarrhythmia Experimental Biology and Medicine, May 1, 2008; 233(5): 558 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Y. Shi, F. F. Hou, H. X. Niu, G. B. Wang, D. Xie, Z. J. Guo, Z. M. Zhou, F. Yang, J. W. Tian, and X. Zhang Advanced Oxidation Protein Products Promote Inflammation in Diabetic Kidney through Activation of Renal Nicotinamide Adenine Dinucleotide Phosphate Oxidase Endocrinology, April 1, 2008; 149(4): 1829 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fan, Y. Wang, Z. Tang, H. Zhang, X. Qin, Y. Zhu, Y. Guan, X. Wang, B. Staels, S. Chien, et al. Suppression of Pro-inflammatory Adhesion Molecules by PPAR-{delta} in Human Vascular Endothelial Cells Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 315 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lefevre, S.-E. Michaud, P. Haddad, S. Dussault, C. Menard, J. Groleau, J. Turgeon, and A. Rivard Moderate consumption of red wine (cabernet sauvignon) improves ischemia-induced neovascularization in ApoE-deficient mice: effect on endothelial progenitor cells and nitric oxide FASEB J, December 1, 2007; 21(14): 3845 - 3852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Lim, E. J. Smart, M. Toborek, and B. Hennig The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3340 - H3347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Flammer, F. Hermann, I. Sudano, L. Spieker, M. Hermann, K. A. Cooper, M. Serafini, T. F. Luscher, F. Ruschitzka, G. Noll, et al. Dark Chocolate Improves Coronary Vasomotion and Reduces Platelet Reactivity Circulation, November 20, 2007; 116(21): 2376 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Datla, H. Peshavariya, G. J. Dusting, K. Mahadev, B. J. Goldstein, and F. Jiang Important Role of Nox4 Type NADPH Oxidase in Angiogenic Responses in Human Microvascular Endothelial Cells In Vitro Arterioscler Thromb Vasc Biol, November 1, 2007; 27(11): 2319 - 2324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Datla, G. J. Dusting, T. A. Mori, C. J. Taylor, K. D. Croft, and F. Jiang Induction of Heme Oxygenase-1 In Vivo Suppresses NADPH Oxidase Derived Oxidative Stress Hypertension, October 1, 2007; 50(4): 636 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Son, Y. Iimuro, E. Seki, T. Hirano, Y. Kaneda, and J. Fujimoto Selective inactivation of NF-{kappa}B in the liver using NF-{kappa}B decoy suppresses CCl4-induced liver injury and fibrosis Am J Physiol Gastrointest Liver Physiol, September 1, 2007; 293(3): G631 - G639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Chan, S. R. Datla, R. Dilley, H. Hickey, G. R. Drummond, and G. J. Dusting Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits Cardiovasc Res, September 1, 2007; 75(4): 710 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Luyendyk, J. D. Piper, M. Tencati, K. V. Reddy, T. Holscher, R. Zhang, J. Luchoomun, X. Chen, W. Min, C. Kunsch, et al. A Novel Class of Antioxidants Inhibit LPS Induction of Tissue Factor by Selective Inhibition of the Activation of ASK1 and MAP Kinases Arterioscler Thromb Vasc Biol, August 1, 2007; 27(8): 1857 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jagadeeswaran, S. Jagadeeswaran, V. P. Bindokas, and R. Salgia Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1488 - L1494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shamaei-Tousi, J. P. Halcox, and B. Henderson Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease Cardiovasc Res, April 1, 2007; 74(1): 19 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Silver, S. D. Beske, D. D. Christou, A. J. Donato, K. L. Moreau, I. Eskurza, P. E. Gates, and D. R. Seals Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47phox Expression and Evidence of Endothelial Oxidative Stress Circulation, February 6, 2007; 115(5): 627 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Jablonski, A. Iannaccone, D. H. Reynolds, P. Gallaher, S. Allen, X. Wang, and A. Reiner Age-Related Decline in VIP-Positive Parasympathetic Nerve Fibers in the Human Submacular Choroid Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 479 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Y. Li, F. F. Hou, X. Zhang, P. Y. Chen, S. X. Liu, J. X. Feng, Z. Q. Liu, Y. X. Shan, G. B. Wang, Z. M. Zhou, et al. Advanced Oxidation Protein Products Accelerate Renal Fibrosis in a Remnant Kidney Model J. Am. Soc. Nephrol., February 1, 2007; 18(2): 528 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nitenberg Macrovascular disease in type 2 diabetes: We do need animal models for in vivo studies Cardiovasc Res, February 1, 2007; 73(3): 450 - 452. [Full Text] [PDF]
|
|
|
|
|
|
Z. Orosz, A. Csiszar, N. Labinskyy, K. Smith, P. M. Kaminski, P. Ferdinandy, M. S. Wolin, A. Rivera, and Z. Ungvari Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H130 - H139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Erdei, Z. Bagi, I. Edes, G. Kaley, and A. Koller H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H649 - H656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Serebruany, A. Malinin, and R. Scott The In Vitro Effects of a Novel Vascular Protectant, AGI-1067, on Platelet Aggregation and Major Receptor Expression in Subjects With Multiple Risk Factors for Vascular Disease. Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2006; 11(3): 191 - 196. [Abstract] [PDF]
|
|
|
|
|
|
K. R. Brunt, K. K. Fenrich, G. Kiani, M. Yat Tse, S. C. Pang, C. A. Ward, and L. G. Melo Protection of Human Vascular Smooth Muscle Cells From H2O2-Induced Apoptosis Through Functional Codependence Between HO-1 and AKT Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 2027 - 2034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Zschenker, T. Illies, and D. Ameis Overexpression of lysosomal Acid lipase and other proteins in atherosclerosis. J. Biochem., July 1, 2006; 140(1): 23 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. X. Liu, F. F. Hou, Z. J. Guo, R. Nagai, W. R. Zhang, Z. Q. Liu, Z. M. Zhou, M. Zhou, D. Xie, G. B. Wang, et al. Advanced Oxidation Protein Products Accelerate Atherosclerosis Through Promoting Oxidative Stress and Inflammation Arterioscler Thromb Vasc Biol, May 1, 2006; 26(5): 1156 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Walston, Q. Xue, R. D. Semba, L. Ferrucci, A. R. Cappola, M. Ricks, J. Guralnik, and L. P. Fried Serum Antioxidants, Inflammation, and Total Mortality in Older Women Am. J. Epidemiol., January 1, 2006; 163(1): 18 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Lund, S. L. Peterson, G. S. Timmins, and M. K. Walker Endothelin-1-Mediated Increase in Reactive Oxygen Species and NADPH Oxidase Activity in Hearts of Aryl Hydrocarbon Receptor (AhR) Null Mice Toxicol. Sci., November 1, 2005; 88(1): 265 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cheng, W. Cao, C. Fiocchi, J. Behar, P. Biancani, and K. M. Harnett In vitro model of acute esophagitis in the cat Am J Physiol Gastrointest Liver Physiol, November 1, 2005; 289(5): G860 - G869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-b. Chen, S.-m. Li, X.-X. Qian, C. Moon, and J. Zheng Tyrosine Phosphorylation of Caveolin 1 by Oxidative Stress Is Reversible and Dependent on the c-src Tyrosine Kinase but Not Mitogen-Activated Protein Kinase Pathways in Placental Artery Endothelial Cells Biol Reprod, October 1, 2005; 73(4): 761 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Fuster, P. R. Moreno, Z. A. Fayad, R. Corti, and J. J. Badimon Atherothrombosis and High-Risk Plaque: Part I: Evolving Concepts J. Am. Coll. Cardiol., September 20, 2005; 46(6): 937 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ilan, O. Tirosh, and Z. Madar Triacylglycerol-Mediated Oxidative Stress Inhibits Nitric Oxide Production in Rat Isolated Hepatocytes J. Nutr., September 1, 2005; 135(9): 2090 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. de Haan, N. Stefanovic, D. Nikolic-Paterson, L. L. Scurr, K. D. Croft, T. A. Mori, P. Hertzog, I. Kola, R. C. Atkins, and G. H. Tesch Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy Am J Physiol Renal Physiol, September 1, 2005; 289(3): F544 - F551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-U. Lee, I. K. Lee, J. Han, D.-K. Song, Y. M. Kim, H. S. Song, H. S. Kim, W. J. Lee, E. H. Koh, K.-H. Song, et al. Effects of Recombinant Adenovirus-Mediated Uncoupling Protein 2 Overexpression on Endothelial Function and Apoptosis Circ. Res., June 10, 2005; 96(11): 1200 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kunsch, J. Luchoomun, X.-l. Chen, G. L. Dodd, K. S. Karu, C. Q. Meng, E. M. Marino, L. K. Olliff, J. D. Piper, F.-H. Qiu, et al. J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 492 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Simoncini, C. Sapet, L. Camoin-Jau, N. Bardin, J.-R. Harle, J. Sampol, F. Dignat-George, and F. Anfosso Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome Int. Immunol., April 1, 2005; 17(4): 489 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Eligini, S. Stella Barbieri, V. Cavalca, M. Camera, M. Brambilla, M. De Franceschi, E. Tremoli, and S. Colli Diversity and similarity in signaling events leading to rapid Cox-2 induction by tumor necrosis factor-{alpha} and phorbol ester in human endothelial cells Cardiovasc Res, February 15, 2005; 65(3): 683 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guan, D. Basi, Q. Li, A. Mariash, Y.-F. Xia, J.-G. Geng, E. Kao, and J. L. Hall Loss of Redox Factor 1 Decreases NF-{kappa}B Activity and Increases Susceptibility of Endothelial Cells to Apoptosis Arterioscler Thromb Vasc Biol, January 1, 2005; 25(1): 96 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Teissier, A. Nohara, G. Chinetti, R. Paumelle, B. Cariou, J.-C. Fruchart, R. P. Brandes, A. Shah, and B. Staels Peroxisome Proliferator-Activated Receptor {alpha} Induces NADPH Oxidase Activity in Macrophages, Leading to the Generation of LDL with PPAR-{alpha} Activation Properties Circ. Res., December 10, 2004; 95(12): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yang, L. J. Roberts, M. J. Shi, L. C. Zhou, B. R. Ballard, A. Richardson, and Z. M. Guo Retardation of Atherosclerosis by Overexpression of Catalase or Both Cu/Zn-Superoxide Dismutase and Catalase in Mice Lacking Apolipoprotein E Circ. Res., November 26, 2004; 95(11): 1075 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li and A. M Shah Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1014 - R1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Chen, F.-Y. Lin, Y.-H. Chen, T.-C. Wu, Y.-L. Chen, and S.-J. Lin Carvedilol Inhibits Tumor Necrosis Factor-{alpha}-Induced Endothelial Transcription Factor Activation, Adhesion Molecule Expression, and Adhesiveness to Human Mononuclear Cells Arterioscler Thromb Vasc Biol, November 1, 2004; 24(11): 2075 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tivesten, A. Barlind, K. Caidahl, N. Klintland, A. Cittadini, C. Ohlsson, and J. Isgaard Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle KATP channel J. Endocrinol., October 1, 2004; 183(1): 195 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Muscoli, I. Sacco, W. Alecce, E. Palma, R. Nistico, N. Costa, F. Clementi, D. Rotiroti, F. Romeo, D. Salvemini, et al. The Protective Effect of Superoxide Dismutase Mimetic M40401 on Balloon Injury-Related Neointima Formation: Role of the Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 J. Pharmacol. Exp. Ther., October 1, 2004; 311(1): 44 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Ali, D. P. Pearlstein, C. E. Mathieu, and P. T. Schumacker Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L486 - L496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, J. Yang, and L. K. Jennings Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H659 - H666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Unthank, K. M. Sheridan, and M. C. Dalsing Collateral Growth in the Peripheral Circulation: A Review Vascular and Endovascular Surgery, July 1, 2004; 38(4): 291 - 313. [Abstract] [PDF]
|
|
|
|
|
|
T. Yoshimoto, N. Fukai, R. Sato, T. Sugiyama, N. Ozawa, M. Shichiri, and Y. Hirata Antioxidant Effect of Adrenomedullin on Angiotensin II-Induced Reactive Oxygen Species Generation in Vascular Smooth Muscle Cells Endocrinology, July 1, 2004; 145(7): 3331 - 3337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.J. Duleba, N. Foyouzi, M. Karaca, T. Pehlivan, J. Kwintkiewicz, and H.R. Behrman Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress Hum. Reprod., July 1, 2004; 19(7): 1519 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M Ridker, N. J. Brown, D. E. Vaughan, D. G. Harrison, and J. L. Mehta Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events Circulation, June 29, 2004; 109(25_suppl_1): IV-6 - IV-19. [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Mamputu and G. Renier Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression: inhibitory effect of antioxidants J. Leukoc. Biol., June 1, 2004; 75(6): 1062 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu, M. H. Noyan Ashraf, M. Facci, R. Wang, P. G. Paterson, A. Ferrie, and B. H. J. Juurlink Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system PNAS, May 4, 2004; 101(18): 7094 - 7099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishii, K. Itoh, E. Ruiz, D. S. Leake, H. Unoki, M. Yamamoto, and G. E. Mann Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages: Activation by Oxidatively Modified LDL and 4-Hydroxynonenal Circ. Res., March 19, 2004; 94(5): 609 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bowers, C. Cool, R. C. Murphy, R. M. Tuder, M. W. Hopken, S. C. Flores, and N. F. Voelkel Oxidative Stress in Severe Pulmonary Hypertension Am. J. Respir. Crit. Care Med., March 15, 2004; 169(6): 764 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kunsch, J. Luchoomun, J. Y. Grey, L. K. Olliff, L. B. Saint, R. F. Arrendale, M. A. Wasserman, U. Saxena, and R. M. Medford Selective Inhibition of Endothelial and Monocyte Redox-Sensitive Genes by AGI-1067: A Novel Antioxidant and Anti-Inflammatory Agent J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 820 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Khatri, C. Johnson, R. Magid, S. M. Lessner, K. M. Laude, S. I. Dikalov, D. G. Harrison, H.-J. Sung, Y. Rong, and Z. S. Galis Vascular Oxidant Stress Enhances Progression and Angiogenesis of Experimental Atheroma Circulation, February 3, 2004; 109(4): 520 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Wasserman and J. N Topper Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications Vascular Medicine, February 1, 2004; 9(1): 35 - 45. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Aller, J. L. Arias, M. P. Nava, and J. Arias Posttraumatic Inflammation Is a Complex Response Based on the Pathological Expression of the Nervous, Immune, and Endocrine Functional Systems Experimental Biology and Medicine, February 1, 2004; 229(2): 170 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Horiuchi, M. Tsutsui, H. Tasaki, T. Morishita, O. Suda, S. Nakata, S.-i. Nihei, M. Miyamoto, R. Kouzuma, M. Okazaki, et al. Upregulation of Vascular Extracellular Superoxide Dismutase in Patients With Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, January 1, 2004; 24(1): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Minuz, P. Patrignani, S. Gaino, F. Seta, M. L. Capone, S. Tacconelli, M. Degan, G. Faccini, A. Fornasiero, G. Talamini, et al. Determinants of Platelet Activation in Human Essential Hypertension Hypertension, January 1, 2004; 43(1): 64 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Chobanian, G. L. Bakris, H. R. Black, W. C. Cushman, L. A. Green, J. L. Izzo Jr, D. W. Jones, B. J. Materson, S. Oparil, J. T. Wright Jr, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Hypertension, December 1, 2003; 42(6): 1206 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Bivalacqua, M. F. Usta, H. C. Champion, P. J. Kadowitz, and W. J. G. Hellstrom Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease J Androl, November 1, 2003; 24(6_suppl): S17 - S37. [Full Text] [PDF]
|
|
|
|
|
|
K. K. Griendling and G. A. FitzGerald Oxidative Stress and Cardiovascular Injury: Part I: Basic Mechanisms and In Vivo Monitoring of ROS Circulation, October 21, 2003; 108(16): 1912 - 1916. [Full Text] [PDF]
|
|
|
|
|
|
D. B. Cowan, M. Jones, L. M. Garcia, S. Noria, P. J. del Nido, and F. X. McGowan Jr Hypoxia and Stretch Regulate Intercellular Communication in Vascular Smooth Muscle Cells Through Reactive Oxygen Species Formation Arterioscler Thromb Vasc Biol, October 1, 2003; 23(10): 1754 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aizawa, H. Wei, J. M. Miano, J.-i. Abe, B. C. Berk, and C. Yan Role of Phosphodiesterase 3 in NO/cGMP-Mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells Circ. Res., September 5, 2003; 93(5): 406 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lassegue and R. E. Clempus Vascular NAD(P)H oxidases: specific features, expression, and regulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R277 - R297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Sundell, P. K. Somers, C. Q. Meng, L. K. Hoong, K.-L. Suen, R. R. Hill, L. K. Landers, A. Chapman, D. Butteiger, M. Jones, et al. AGI-1067: A Multifunctional Phenolic Antioxidant, Lipid Modulator, Anti-Inflammatory and Antiatherosclerotic Agent J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1116 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Guo, J. Wei, Y. Inoue, F. J. Gonzalez, and P. C. Kuo Serine/threonine phosphorylation regulates HNF-4alpha -dependent redox-mediated iNOS expression in hepatocytes Am J Physiol Cell Physiol, April 1, 2003; 284(4): C1090 - C1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z S Nedeljkovic, N Gokce, and J Loscalzo Mechanisms of oxidative stress and vascular dysfunction Postgrad. Med. J., April 1, 2003; 79(930): 195 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Basta, L. Venneri, G. Lazzerini, E. Pasanisi, M. Pianelli, N. Vesentini, S. Del Turco, C. Kusmic, and E. Picano In vitro modulation of intracellular oxidative stress of endothelial cells by diagnostic cardiac ultrasound Cardiovasc Res, April 1, 2003; 58(1): 156 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dechend, C. Viedt, D. N. Muller, B. Ugele, R. P. Brandes, G. Wallukat, J.-K. Park, J. Janke, P. Barta, J. Theuer, et al. AT1 Receptor Agonistic Antibodies From Preeclamptic Patients Stimulate NADPH Oxidase Circulation, April 1, 2003; 107(12): 1632 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Martinet, M. W.M. Knaapen, G. R.Y. De Meyer, A. G. Herman, and M. M. Kockx Overexpression of the Anti-Apoptotic Caspase-2 Short Isoform in Macrophage-Derived Foam Cells of Human Atherosclerotic Plaques Am. J. Pathol., March 1, 2003; 162(3): 731 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Lopes, K. L. Martin, K. Nashar, J. D. Morrow, T. L. Goodfriend, and B. M. Egan DASH Diet Lowers Blood Pressure and Lipid-Induced Oxidative Stress in Obesity Hypertension, March 1, 2003; 41(3): 422 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Tardif, J. Gregoire, L. Schwartz, L. Title, L. Laramee, F. Reeves, J. Lesperance, M. G. Bourassa, P. L. L'Allier, M. Glass, et al. Effects of AGI-1067 and Probucol After Percutaneous Coronary Interventions Circulation, February 4, 2003; 107(4): 552 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Watanabe, Y. Chu, J. J. Andresen, H. Nakane, F. M. Faraci, and D. D. Heistad Gene Transfer of Extracellular Superoxide Dismutase Reduces Cerebral Vasospasm After Subarachnoid Hemorrhage Stroke, February 1, 2003; 34(2): 434 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iglarz, R. M. Touyz, F. Amiri, M.-F. Lavoie, Q. N. Diep, and E. L. Schiffrin Effect of Peroxisome Proliferator-Activated Receptor-{alpha} and -{gamma} Activators on Vascular Remodeling in Endothelin-Dependent Hypertension Arterioscler Thromb Vasc Biol, January 1, 2003; 23(1): 45 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Alexander Oxidized LDL Autoantibodies, Endothelial Dysfunction, and Transplant-Associated Arteriosclerosis Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 1950 - 1951. [Full Text] [PDF]
|
|
|
|
|
|
T. K. Nakahashi, K. Hoshina, P. S. Tsao, E. Sho, M. Sho, J. K. Karwowski, C. Yeh, R.-B. Yang, J. N. Topper, and R. L. Dalman Flow Loading Induces Macrophage Antioxidative Gene Expression in Experimental Aneurysms Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 2017 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Fang, S. Kinlay, D. Behrendt, H. Hikita, J. L. Witztum, A. P. Selwyn, and P. Ganz Circulating Autoantibodies to Oxidized LDL Correlate With Impaired Coronary Endothelial Function After Cardiac Transplantation Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 2044 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li, N. P. Gall, D. J. Grieve, M. Chen, and A. M. Shah Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure Hypertension, October 1, 2002; 40(4): 477 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Martinet, M. W.M. Knaapen, G. R.Y. De Meyer, A. G. Herman, and M. M. Kockx Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques Circulation, August 20, 2002; 106(8): 927 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T Gewaltig and G. Kojda Vasoprotection by nitric oxide: mechanisms and therapeutic potential Cardiovasc Res, August 1, 2002; 55(2): 250 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. NICKENIG, S. BAUDLER, C. MULLER, C. WERNER, N. WERNER, H. WELZEL, K. STREHLOW, and M. BOHM Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo FASEB J, July 1, 2002; 16(9): 1077 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Li and A. M. Shah Intracellular Localization and Preassembly of the NADPH Oxidase Complex in Cultured Endothelial Cells J. Biol. Chem., May 24, 2002; 277(22): 19952 - 19960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fan, B. Sun, Q. Gu, A. Lafond-Walker, S. Cao, and L. C. Becker Oxygen radicals trigger activation of NF-kappa B and AP-1 and upregulation of ICAM-1 in reperfused canine heart Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1778 - H1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kumaran and K. Shivakumar Calcium- and superoxide anion-mediated mitogenic action of substance P on cardiac fibroblasts Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1855 - H1862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Stoica, M. Goddard, and S. R. Large The endothelium in clinical cardiac transplantation Ann. Thorac. Surg., March 1, 2002; 73(3): 1002 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ide, H. Tsutsui, N. Ohashi, S. Hayashidani, N. Suematsu, M. Tsuchihashi, H. Tamai, and A. Takeshita Greater Oxidative Stress in Healthy Young Men Compared With Premenopausal Women Arterioscler Thromb Vasc Biol, March 1, 2002; 22(3): 438 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Porcel, L. O Lerman, D. R Holmes Jr., D. Richardson, C. Napoli, and A. Lerman Chronic antioxidant supplementation attenuates nuclear factor-{kappa}B activation and preserves endothelial function in hypercholesterolemic pigs Cardiovasc Res, March 1, 2002; 53(4): 1010 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li, A. M. Mullen, S. Yun, F. Wientjes, G. Y. Brouns, A. J. Thrasher, and A. M. Shah Essential Role of the NADPH Oxidase Subunit p47phox in Endothelial Cell Superoxide Production in Response to Phorbol Ester and Tumor Necrosis Factor-{alpha} Circ. Res., February 8, 2002; 90(2): 143 - 150. [Abstract] [Full Text] [PDF]
|
|